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Depends. If a change in the microbiome is observed that correlates with improvement in symptoms, and the microbiome over time reverts back while the patient relapses back into a pre-FMT symptomatic state, I think that would suggest that the gut is very important. Assuming that there is proper...

A variation of the question above: if enough patients take part, would it be possible to recognize several subgroups from the data?

It is not merely arrogance. It is a deliberate tactic to discredit critics of his approach. First it misleads the reader into thinking that CBT for cancer is comparable to CBT for CFS. Then in effect he says that critics object to CBT for petty reasons. I suppose that makes him arrogant in the...

Or maybe the psychotherapy for CFS is horribly misguided and often harmful.

I was thinking about this today. Unblinded clinical trials with self-reported outcomes would probably not be accepted as evidence by Cochrane if the treatment in question was a fringe treatment like homeopathy, reiki, etc. It would probably be considered embarassing to even take any of such...

This sounds interesting. This seems to suggest that the treatment that can reverse these symptoms might have the biggest impact on ability to work.

The people involved in this at Cochrane seem to have difficulty understanding that modest self-reported positive effects is exactly what you would expect if the treatment did not work but was tested without adequately controlling for bias while introducing positive expectations. They might even...

The CBT/GET narrative is apparently designed to anticipate and deflect reports of harm. Presumably its designers created it with the firm conviction that in ME/CFS there is nothing wrong in the body, and that therefore exercise cannot harm. They offer all sorts of explanations and...

That was unlikely to be 15000 patients but included friends and family members. It's also much easier to sign a petition than to give a saliva or blood sample.

Maybe we need a trial of aggressive rest therapy? :D With just minimum activity to prevent the worst deconditioning.

Right. The American patients are often on half a dozen medications.

The vicious circle of psychosomatic medicine: An illness is poorly understood -> psychosomatic medicine zealots seize the opportunity, declare it a psychogenic illness and make up some stigmatizing narrative to discredit sufferers and control them -> entrenched business interests and public...

It seems that back in the day, ideas weren't tested to see if they are correct, they were simply asserted to be correct. Sharpe and colleagues continue this tradition.

In psychology, the patient is the agent of change could be interpreted in a different way too. One that has to do with protesting abysmal quality.

https://www.physiology.org/doi/abs/10.1152/ajpheart.00680.2018?journalCode=ajpheart This isn't ME/CFS research but it's not unrelated either, so I thought this should be in the ME/CFS research section.

That is not the best choice of words but the rest of the leaflet is good.

Can you say more about that kind of PEM?

This might be similar to people being more irritable and cranky when they are really exhausted. Which I think happens because in an exhausted state there is an inability to resist stress, so people tend to react to minor things. That seems similar to the "inability to filter out" idea by @inox.

Once the hope turns out to be false hope, and the patient understands that providing false hope to patients like them is the only real plan pursued by the healthcare system, hopelessness and despair sets in.

Maybe they think like this: Medically unexplained symptoms are a somatoform disorder but we don't say that openly. Hope, motivation and positive expectations treat the sick mind. A bogus treatment is an acceptable way to deliver hope, motivation and positive expectations (placebo effect). It...