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So this version is still undergoing review in the Journal of Translational Review. Does anyone know if/how it's possible to make community comments? (Potentially, there looks to be quite a good, transparent review process. I don't know if that is standard practice for journals or not.)

Yep :confused: So, the suggestion is that doctors should respond to a medically unexplained symptom with 'appropriate explanations'. But, if there was a well-founded, evidence-based explanation for the report of the symptom, then it's either not a 'medically unexplained symptom' or the patient...

KATP channels seem potentially relevant to ME/CFS - ATP signalling; vascular tone regulation; mention of sepsis, ROS. I don't have time/capacity right now to dig into that paper that @Snow Leopard posted. I'd have to draw some diagrams to work out what is making what go up or down. But @Snow...

From my memory of the video: Sargant (in the UK) came up with the idea and Bailey copied it and took it further. Sargant realised after two patients died that weeks restrained in heavy sedation was not a good idea - and so he 'roused' the patients for meals. Bailey had his patients tube-fed...

Re Dr Bailey: 7.20 mins "He saw his cures as being a great answer to just about every mental illness. And with the force of his personality he gathered round him people who did believe in him, both medical people and nursing staff, but also a large personal following of patients. He was a very...

This is from a good article by Ed Yong that Slysaint posted on the Possibility of ME or PVFS after Covid-19 thread https://www.theatlantic.com/health/...9-recognition-support-groups-symptoms/615382/ What do we know about the antibody test? How reliable is it? Is there any evidence that it's...

They were worn around the waist. Yeah, it isn't clear from the text if the selection was only of children who met the Fukuda definition but not a definition that they equate with ME. (Fukuda compliance but not CCC compliance) or (Fukuda compliance but not IOM compliance) is potentially quite...

Certainly that's what I would expect. But I'm not sure that Figure 1 really shows a lot of night-time activity. Neither group is doing much between 10 pm and 6 am. The activity monitor was only worn for one day by each participant. This is acknowledged as a limitation by the authors -...

From Leonard Jason's group. I find this separation a bit odd - I don't think there's enough evidence to differentiate two conditions. . It's not clear if people who met the requirement for both CFS and ME are included in this study. 35 children who met the Fukuda criteria and 15 healthy...

I'm currently working with our regional health authority on some online guidance for Allied Health covering both chronic fatigue and ME/CFS. It's part of the HealthPathways online information service. 'Allied Health' covers people such as physios, occupational therapists, dieticians and...

Paul Fisher's team found that Complexes I, II and III were working ok in people with ME and Warren Tate's team found normal levels of CoQ10 in the cells of people with ME. So this condition doesn't seem to equal ME - but it sounds like a condition worth ruling out. I hope everyone with...

To clarify for those who, like me, were confused by the AfME tweet above, Dr Mark Guthridge summarised Dr Komaroff's article for AfME's magazine. So much of the information in the summary is wrong or at least inadequately supported by facts. I'm surprised to see Dr Guthridge disseminating...

For what it's worth, sulphonylureas are quite widely used herbicides e.g. from a study of spray diaries of NZ cereal growers In a quick google, I didn't find such much evidence of, or concern about, toxicity to humans.

A post with the story of hydroxychloroquine has been moved here: Chloroquine and Hydroxychloroquine as treatments for Covid-19

Linking to: Explore - A Systematic Review of The Evidence Base for the Lightning Process - 2020 - by Phil Parker et al The heading says most of what you need to know - Phil Parker, the person with the most financial and reputational reasons to find that the Lightning Process is useful, has...

I was surprised at the government people saying that the freight idea is low probability. That said, it could have come from a quarantine facility. Only some of the samples from quarantine have had the genome described, so there still might be some that match the cool store cluster. And, in...

An update on the NZ cluster: more cases have been identified, with most related to the cool store facility. The genome of the Covid strain of this cluster does not match the genomes from cases in our border quarantine facilities that have been examined. The swabbing of the surfaces at the cool...

To be fair, the authors seem to have done a pretty good job collating the evidence. It's just that they seem to have left their skepticism of the evidence at the door. For example, traumatic brain injury: So, if a patient has had moderate or severe brain injury, they deserve an unbiased...

There's more: This is in relation to the use of a placebo induction method (e.g. a saline injection) that the doctor says will bring on a seizure so that it can be observed: Interictal means 'between the seizures' - so this quote is saying that cognitive and behavioural and other issues aside...

I think they mean, 'PNEs are more frequently diagnosed in women'. Noting that they occur in children and that semiology here is a fancy word for diagnostic signs: Yep, that's the level of sophistication the signs are at - if the patient brings a teddy bear into the EEG unit, you can be very...