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Which suggests that most symptoms in these patients is not explained by pulmonary dysfunction.

Yes, their theory does involve the HPA axis, even though they don't explicitly mention it in the current manuscript. The Corticotropin-releasing hormone receptors lead to a release of ACTH, which in turn stimulates the production of corticoids. The Urocortins are part of the...

Really? I posted in prior threads why I disagree with their proposed hypothesis and why it doesn't match what is already known about the endocrinology of ME/CFS. I didn't find the mechanism proposed in the manuscript to be terribly plausible. They are claiming that one or two or three...

Note that despite all the headlines, this study didn't measure LongCovid as they only analysed data for up to 28 days.

It annoys me that they haven't bothered to investigate the obvious - namely there may be other tick-borne infections that are specific to Australian ticks.

Also note, the claims that patients were more sensitive to the hemodynamic effects of the drug is not generalisable, given they are not matched cohorts - the "healthy controls" from the "Phase 1 clinical trial" were 100% male, with mean age 34.1±7.6 years, whereas this study was 57% female with...

"Cure". Claims like this are flat out irresponsible...

So what? Post the ITT data anyway, since this is a pilot trial. It just sounds like excuses for not doing things properly. I don't find any of this compelling given it was a open label trial with no objective outcomes.

That is a classic strawman argument. Does the guy understand that almost no parents are telling their children they're going to get LongCovid?

Any discussion/report that discusses biomarkers/tests that doesn't explicitly discuss sensitivity and specificity suggests they don't know what they are talking about. They don't know. It's funny how anything measured is assumed to be pathogenic, rather than merely an adaptive response, or...

Yes, there will be minimal protection against symptomatic infection if there was no seroconversion.

Is this really evidence of lack of seroconversion or evidence for lack of sensitivity of their test? https://wwwnc.cdc.gov/eid/article/27/9/21-1042_article

I suggest the deeper breathing may be a positive (central) adaptation to ongoing Group III and IV muscle afferent signals. (this also means I don't expect to see it in all patients) The physiological effects of slow breathing in the healthy human...

VE/VCO2 is not unitless ratio. Instead, it is a rate. Minute ventilation (VE) is ml/minute, the other is just volume of CO2 exhaled in ml. VCO2 was not increased compared to controls (it was actually lower compared to unmatched, so there was no relative hypocapnia as would be expected if there...

No, I think it means some people like me do the minimum amount of intense activity to maintain an average level of aerobic fitness. This reminds me of you people (you know who you are!) claiming we should do a week of CPETs to see what happens. I'm feeling horrified just thinking about it.

The overall breathing pattern cannot be due to a pulmonary disorder, there was no overall difference in V̇CO2 and no difference in OUES (Oxygen uptake efficiency slope). Assuming the observed effect is genuine, Dane's hypothesis that it is an adaptation to improve alveolar ventilation caused by...

Yes, at submaximal power output, sub optimal pacing/cadences and variations in mechanical efficiency can cause differences at a given level of effective power output. Though VO2Max itself should be similar, if the participant is able to reach it on both tests.

No, because most patients tend to pace themselves and avoid all circumstances of intense exercise, whereas healthy people may occasionally do it. edit - further comments - the "fitness matching" seems suspicious, because cardiopulmonary fitness is based on VO2peak in mL/(kg·min). But this...

I'm not sure this is a meaningful finding. Participants who have not exercised intensely in a long time and/or are unfamiliar with riding a bike, adopt less mechanically efficient pedalling cadence and breathing rate the first time they do such activity in a long time. This is one of the...

Which ones? There are so many! ;)