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Ordinary people can just keep going for hours or most of the day, with little impairment. If they become fatigued it's not a major problem and they can recover easily.

I had similar thoughts. The misunderstanding seems to work like this: The exertion intolerance and PEM are ignored or misrepresented as fatigue. The fatigue is misrepresented as chronic fatigue that does not change much. It is then assumed that the way a patient looks at any given moment is...

My muscle biopsy showed some degree of mitochondrial dysfunction, but not severe enough to count as proper mitochondrial myopathy.

Why are they doing IPD analysis then? It sounds like IPD would make it easier to obtain statistically significant positive results. But didn't the previous review already obtain them? Maybe they're hoping to get positive results on wider range of outcomes? Obviously it doesn't do anything to...

How does an IPD meta analysis work? Does it focus on the probably few patients with good results and claim the improvement can be attributed to the intervention?

Some parts read like the intent is to find a name for a category of chronic illnesses that are triggered by infections. Other parts read like the idea is to replace the current names and diagnostic entities with a single new one. At the very least the whole thing can be criticized for lack of...

Any comment @Jonathan Edwards? Am I the only one who thinks this is really interesting? It seems that this might be a useful diagnostic test that also helps get us closer to understand the problem. It also aligns with the old description of PEM as postexertional muscle weakness. Why I think...

I don't know. I'm not defending their vision, in case it was not clear. I'm saying that infection-associated chronic illness is a useful term in some contexts that does not require changing any names. Trying to invent a unifying name and diagnostic label to REPLACE what is currently ME/CFs, long...

infection-associated chronic illness would refer only to the infectious trigger cases. I can see why researchers need a name for "unexplained chronic illnesses that can be traced back to an infection and overlap significantly with each other independently of the infectious agent".

I agree this looks incompetent. I see nothing wrong with using the term infection-associated chronic illness to refer to this group of illnesses. The NASEM has already used it in a professional setting. We do need such a term to refer to these illnesses as a group. But is the intent to create a...

The bigger picture of how the brain controls muscle contraction. The nerve cell's axons connect to a structure called the neuromuscular junction, which transmits the signals to the sarcolemma, which is excitable and can propagate it across the cell.

The sarcolemma is the muscle cell's plasma membrane. While cell membrane covers the entire components of a cell, plasma membrane covers only the cell's organelles. Some main differences between the two are the fact that the plasma membrane encloses the organelles, whereas the cell membrane...

An illness definition based on a single nonspecific symptom cannot be taken seriously. It should be obvious to anyone that it's meaningless. The people behind this attempt to revive the Oxford criteria appear to intend using ME/CFS to give some credibility to this. Even from a language point of...

Being sick with an illness that is difficult or even devastating is not understood by society, and therefore often misunderstood as some form of bad behavior or character flaw does not have treatments has uncertain prognosis with little prospects of improvement in the future will cause...

SSRIs lower blood pressure, right? That's going to cause problems.

Yes these things are not always mentioned but they play a very big role. Behind my very small success stories with walking/swimming is also the fact that I live with my parents who do most of the household work. If I had to spend more energy on these things I would have much less, if any, left...

Yes. Would it justify a retraction or some sort of warning? It seems like a form of lying. For clarity here's the definition of Oxford CFS criteria: a) A syndrome characterized by fatigue as the principal symptom. b) A syndrome of definite onset that is not lifelong. c) The fatigue is severe...

Garner has been banned from the Long Covid Apheresis Community facebook group after a community vote.

They write "The forthcoming individual patient data meta-analysis of exercise therapy trials for CFS/ME is a further step in the right direction. The reference is this page https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018107473

Yes these kids will end up hating psychosomatics once they become more mentally independent.