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This study claims estimates of heritability using LDSC underestimate by 30% (and 50% in simulations) https://pmc.ncbi.nlm.nih.gov/articles/PMC10066905/

Okay, I think I understand you better. You were comparing heritability of ME/CFS to other diseases. The liability heritability of Crohn's using LDSC is around 24%. That's higher than the 10% found by DecodeME. I find that disappointing as well. Maybe the estimate can be revised substantially in...

If you read the Wikipedia article, it explains that the more SNPs are considered, the more accurate heritability estimates from GWAS become. Things like body parameters have presumably heritability estimates that can draw on far more SNPs than diseases. I'm not sure that the second article is...

GWAS tend to underestimate heritability. https://en.wikipedia.org/wiki/Missing_heritability_problem

I believe the inability to find an existing drug that works for ME/CFS also suggests that ME/CFS is quite different from other diseases, or at least the ones that look similar enough to make someone believe a treatment used for another disease would be worth trying in ME/CFS. The alternative...

ME/CFS research has been conducted since around 1990, and there have been clinical trials of treatments. None of them have convincingly shown a benefit. Finding a working treatment with this approach is difficult and could take a very long time.

The next big step? Get SequenceME funded.

Carson seems to believe fatigue can be treated by modifying expectations. When I read that, I feel misunderstood because the experience of the illness includes the strong experience of POWERLESSNESS of positive expectations, attitudes, thinking, and the difficulty predicting things precisely...

Yes, I got much better results after insisting that it limit its answers to only the most robust findings, be highly skeptical, and avoid overinterpretation. This was in response to a demand for a hypothesis about type-1 diabetes and some other randomly selected genes. It gave me this: This...

I think increased pain sensitivity (along with anxiety, feeling fragile, etc.) are often misunderstood. They're often a survival strategy by a brain that is sensing illness or vulnerability. Having increased pain sensitivity changes the behaviour of a person in a way that reduces certain risks...

Yes, they're very good at these things. It's just like Wikipedia was always good when it came to uncontroversial topics that had definitive answers, while being unreliable and inevitably biased when it came to other things.

I like that it's good at summarising information. I'm not sure how good it is at creating hypotheses. It's useful for sure, but maybe not for all tasks. I can believe that it might be better than doctors at diagnosing illness, but this is presumably in controlled setting for which it has been...

My impression of ChatGPT is that it's good at being optimistic, seeing connections, and overinterpreting things. Likely because it's imitating hypothesis papers that are in this style. It's a bit like a Cort Johnson with a PhD in biology.

Carson gives the impression of citing an authoritative source on the high misdiagnosis rates in ME/CFS diagnosed by questionnaire when this is not the case. "Diagnosis was done by questionnaire" makes it sound like patients filled in questionnaires about symptoms, while they were asked about...

The impression is that they are keen to claim ME/CFS as their turf. They see the illness through a lens of depression and anxiety and what patients say can be ignored.

From what I understand these are parts of the brain involved in homeostasis. Things like fluid balance and blood pressure, release of hormones.

Wouldn't this also work for ME/CFS? Except that the T cell attack is either more subtle and not visibile on imaging, or that instead of an attack, there is a persistent danger signal that makes cells exposed to it dysfunctional. That dysfunction then maybe somehow feeds back to the immune system...

I don't see how the polymorphic nature of DQ would lead to spurious associations. What may be happening is a DQ variant that's not contributing to disease being in linkage equilibrium with another variant that is contributing to disease, and of which we don't yet have knowledge. Since DQ was...

I'm sure the data will be used eventually. The prevalence of CFS in the dataset is 3.65% which suggests potential issues with overdiagnosis.

It's that GWAS of somatic symptom disorder, which also assessed FND https://www.medrxiv.org/content/10.1101/2025.07.16.25331639v1.full.pdf