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  1. Andy

    Animal research for ME

    As Wonko points out, there are some who claim to have an animal model already, but it is simply rodents exercised to exhaustion, so hardly a useful one. Frankly, I would need to see the details before getting behind the idea of experimentation on animals for ME research. One person's "good...
  2. Andy

    Virtual reality exercises at home for post COVID-19 condition: a feasibility study, 2022, Groenveld et al

    ABSTRACT Background: Between 30-76% of COVID-19 patients have persistent physical, cognitive and/or mental symptoms, sometimes up to 9 months after acute COVID-19 infection. The expected rush of patients needing rehabilitation put pressure on primary care practices and resources, particularly...
  3. Andy

    Actigraphic Physical Activity, Pain Intensity, and Polysomnographic Sleep in Fibromyalgia, 2022, McGovney et al

    ABSTRACT Introduction Fibromyalgia involves chronic pain and disrupted physical activity and sleep. Research examining the relationship between pre-bedtime physical activity, pain, and objective sleep is limited. This study examined whether objectively measured physical activity levels (via...
  4. Andy

    No exaggerated tremor severity perception in functional tremor, 2022, Huys, Edwards et al

    Abstract Background Symptoms of functional neurological disorder tend to be variable, yet patients often report them being present constantly and of permanently severe intensity. Furthermore, they typically worsen when they are mentioned or during clinical examination. Such phenomena are...
  5. Andy

    SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations post recovery, 2022, Frere et al

    Abstract The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred to as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying long COVID biology, we...
  6. Andy

    Long Covid in the media and social media 2022

    "Rehabilitation based on medical needs using a multi-disciplinary approach, freed from counterproductive administrative and financial hurdles, with sufficient support for those with little or no access to informal care." https://longcovideurope.org/
  7. Andy

    Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I, 2022, Rodríguez-Nuevo et al

    Eggs can survive decades without signs of aging. Now, scientists may know why "Mitochondria power the cell by taking electrons and using them to make a cellular fuel called ATP, through a process known as oxidative phosphorylation. It doesn’t happen all at once, but in a series of linked steps...
  8. Andy

    Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I, 2022, Rodríguez-Nuevo et al

    Abstract Oocytes form before birth and remain viable for several decades before fertilization1. Although poor oocyte quality accounts for most female fertility problems, little is known about how oocytes maintain cellular fitness, or why their quality eventually declines with age2. Reactive...
  9. Andy

    Lightning Process study in Norway - Given Ethics Approval February 2022

    Trial By Error: Mom Speaks Out About NHS “Abuse” of Daughter; Norway Approves Lightning Process Study "I have written frequently about the Lightning Process, most recently about a proposed clinical trial in Norway. On July 13th, NEM, the Norwegian research ethics authority, announced that it...
  10. Andy

    United Kingdom: Teenager Ella Copley's experience with severe ME/CFS

    Trial By Error: Mom Speaks Out About NHS “Abuse” of Daughter; Norway Approves Lightning Process Study "On Monday, The Times (UK) published a story about a 17-year-old girl with ME who has experienced hospital treatment that her family has referred to as “neglect and abuse.” The details are...
  11. Andy

    Making space for disability studies within a structurally competent medical curriculum: reflections on long Covid, 2022, Hunt

    "An important structural issue of relevance to the above discussion is the historical tendency in healthcare settings, notably in the UK, to recommend cognitive behavioural therapy (CBT) and/or graded exercise therapy (GET) for particular conditions that have been positioned as ‘medically...
  12. Andy

    Making space for disability studies within a structurally competent medical curriculum: reflections on long Covid, 2022, Hunt

    Abstract While critically informed approaches to medical education are increasingly advocated in literature, discussion of the potential role of disability studies in informing pedagogy and practice is largely lacking. The emergence of long Covid, alongside the strong possibility of a wave of...
  13. Andy

    Physical and psychological reconditioning in long COVID syndrome: Results of an out-of-hospital exercise and psychological..., 2022, Compagnoa et al

    Full title: Physical and psychological reconditioning in long COVID syndrome: Results of an out-of-hospital exercise and psychological - based rehabilitation program Abstract Background Long Covid Syndrome (LCS) is used to describe signs and symptoms that continue or develop after acute...
  14. Andy

    Preprint: Characteristics of Patients Referred to a Cardiovascular Disease Clinic for Post-Acute Sequelae of SARS-CoV-2 Infection, 2021, Wang et al

    Now published. Abstract Introduction There is limited literature on cardiovascular manifestations of post-acute sequelae of SARS-CoV-2 infection (PASC). Methods This observational study aimed to describe the characteristics, diagnostic evaluations, and new cardiac diagnoses in patients...
  15. Andy

    ‘Long COVID’: Symptom persistence in children hospitalised for COVID-19, 2022, Asadi-Pooya et al

    Abstract Aim We aimed to describe the long-term outcome with respect to symptom persistence amongst children hospitalised for COVID-19. Methods This was a follow-up study of 58 children and adolescents hospitalised with COVID-19. For all patients, the data were collected in a phone call to the...
  16. Andy

    Cardiometabolic outcomes up to 12 months after COVID-19 infection. A matched cohort study in the UK, 2022, Rezel-Potts et al

    Abstract Background Acute Coronavirus Disease 2019 (COVID-19) has been associated with new-onset cardiovascular disease (CVD) and diabetes mellitus (DM), but it is not known whether COVID-19 has long-term impacts on cardiometabolic outcomes. This study aimed to determine whether the incidence...
  17. Andy

    A study of high neuroticism in long-term survivors of childhood, adolescence, and young adult cancers, 2022, Dhal et al

    "Primary outcome variable Neuroticism was self-rated on an abridged version of The Eysenck Personality Questionnaire (EPQ-N) with six items concerning long-term personality characteristics17. Each item was rated as present (1) or absent (0). The sum score ranged from zero to six, and higher...
  18. Andy

    A study of high neuroticism in long-term survivors of childhood, adolescence, and young adult cancers, 2022, Dhal et al

    Abstract Neuroticism is a basic personality trait concerning negative feelings under stressful conditions. Our purpose was to examine the rate of high neuroticism and factors associated with high neuroticism in long-term (≥ 5 years) survivors of childhood, adolescent, and young adult cancer...
  19. Andy

    Protocol: DecodeME: community recruitment for a large genetics study of ME/CFS, 2022, Devereux-Cooke et al

    We are partnering with a fulfillment company that will send the spit kits out for us, so it will be automated.
  20. Andy

    Membrane curvature and PS localize coagulation proteins to filopodia and retraction fibers of endothelial cells, 2022, Carman et al

    Key Points Convex membrane curvature and phosphatidylserine create discreet binding locations for lactadherin and coagulation factor V(a) Stressed endothelial cells extend filaments with both high convexity and PS, establishing discreet sites of prothrombinase activity Prior reports...
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