Search results

The only secondary outcome that the authors claim showed any difference was in this same small strange mild/moderate stress category. And, nope, that's not going to fly with me. Knowing that the total sample, spread between the treatment and the placebo was only 16, and knowing that that MM...

I've tried to find out how many patients were in the post-hoc mild/moderate groups. I don't think the paper tells us that anywhere. Table 2 gives the characteristics of the mild/moderate and severely stressed groups, but the numbers are for the patients in both treatment arms together. I mean...

I had to laugh at that. Stress-related trouble. Despite that, they had to screen people with FM in order to weed out those who did not score highly enough on the stress measuring survey. The study is to see if this magnesium supplement reduces reported stress. The study failed to show a...

Interesting to note that the FM patients had normal levels of Mg in the serum and in erythrocytes at baseline. However, it's noted that magnesium can be released from the bones to maintain Mg blood levels.

A research update from OMF-supported researcher Chris Armstrong Chris Armstrong - Melbourne ME/CFS researcher, research updates

That's a really impressive amount of money being provided by the UK ME Association.

Such good points @bobbler. There's also the problem that people with ME/CFS are trying to do things that were, pre-illness, easily accomplished. We expect to be able to do the things we could do. We often don't want to acknowledge, even to ourselves, that we can't do something. And, with...

Yes, the abstract isn't very helpful, and, at the moment, the abstract is all there is. The paper is labelled 'online ahead of print'. If the definition of ME/CFS and severe ME/CFS is consistent with another recent paper by Leonard Jason, then 'severe ME/CFS' refers to compliance with multiple...

On implementation of NICE Guidelines:

Fair enough - the abstract seems to be suggesting there are these markers of perturbations in the DRG, but not cell death. Would we necessarily see leucocyte infiltration if the dorsal root ganglia are just 'perturbed'? Is there leucocyte infiltration when olfactory nerves are disturbed enough...

Yes, re a threshold that might be crossed to reach a clinically observable level. For example, if ME/CFS operated like my idea of how ciguatera poisoning works, or some other neurotoxins might work, then a single exposure can be enough to cause acute disease and subsequently some people have...

Predictors of Submaximal Exercise Test Attainment in Adults Reporting Long COVID Symptoms, 2022, Romero-Ortuno et al A paper from an Irish group of researchers - researching CPET performance in people with Long Covid while seemingly being unaware of PEM and repeat CPETs. Looks as though they...

I don't think this tells us anything much, other than these researchers were ill-equipped to be carrying out CPET research on Long Covid cohorts. The people included in the study almost certainly had a range of reasons for their reported fatigue and lingering symptoms, and there was no attempt...

Persistent SARS-CoV-2 Effects Induce Neuropathy Signature in Dorsal Root Ganglia Underlying Hypersensitivity in a Hamster Model, 2022, Serafini et al A report (abstract only at this stage) of a hamster model of something like Long Covid after SARS-CoV-2 infection. The ongoing symptoms that...

(Catching up on our backlog of reports) It was debatable where to put this thread - the standard research forum, or the psychosomatic research forum. I've gone for the latter, due to the paper's suggestion that GET and CBT were useful. Interesting though to see the concerns about...

(an old paper, mentioned on another thread here) Interventions for the Treatment and Management of Chronic Fatigue Syndrome: A Systematic Review https://jamanetwork.com/journals/jama/article-abstract/194209 Penny Whiting, MSc; 1 Anne-Marie Bagnall, PhD; 1 Amanda J. Sowden, PhD; 1 John E...

The drop out rate was not unreasonably high, but there was probably a skew as to which type of patients dropped out. I can imagine those who had had an organ transplant would be less likely to drop out, whereas patients who did not have ongoing symptoms would be more likely to drop out. The...

From the abstract only The sample is hospitalised and high risk patients. PASC as defined here is not Long Covid or ME/CFS, simply one or more persistent symptoms 2 to 3 months after acute infection/hospital discharge. There's no mention of gender being associated with PASC. It's surprising...

ABSTRACT Background The incidence of persistent clinical symptoms and risk factors in Post-Acute Sequelae of SARS-CoV-2 (PASC) in diverse US cohorts is unclear. While there are a disproportionate share of COVID-19 deaths in older patients, ethnic minorities, and socially disadvantaged...

Really, this idea that an infection could cause damage, sometimes permanent damage to nerves and so affect body function should not be so strange. We know that Covid-19 can affect the sense of smell - resulting in people not being able to smell at all, or changing the perception of odours. It...