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It is surprisingly good. Of course there's the question of whether PT's really need to be involved and whether people with Long Covid really need detailed plans. But this article makes the point that an educated PT can advocate for the patient, informing other health care professionals and...

Post-acute COVID-19 is characterized by gut viral antigen persistence in inflammatory bowel diseases, 2022, Zollner et al An interesting paper from an Austrian team.

To me, this idea makes some sense. I think the strongest argument I've heard against this idea of persistence of pathogen antigens is that the antigens would break down over time, the body would recycle and eliminate them. So, perhaps it might work for an illness of months or even a few years...

Thanks @LarsSG Seems like an important finding.

I thought that was worth reading; a very good account of mild Long Covid. There was the observation that a lot of athletes are getting Long Covid. Which raises speculation: Did exertion while ill increase their risk of LC? Did their high level of fitness somehow make their immune system too...

I have to admire whoever in English National Opera came up with this scheme to cope with the vagaries of being in the 'live entertainment' industry during a global pandemic i.e. move into the health care industry. Lest people new to the forum feel we have been overly harsh in the assessment of...

Interesting study at around the one year mark. This is a bit scary: There are % errors in Table 1. Figure 1: Box and whisker plots of statistically significant hemostatic, endothelial and inflammatory parameters Also: Some questions from our point of view are, do these results...

Linking the EMEA News thread: there's a webinar coming up focused on improving things in the Eastern European part of the world.

Hillary Johnson wrote Oslers web. There's an interview with her by @ScottTriGuy linked here: My podcast: Medical Error Interviews

I thought this was worth posting for a couple of reasons: One is that a rehabilitation robot is being used. That puts a whole new spin on the idea of moving as many patients away from expensive doctors and towards less expensive rehabilitation staff. I wonder exactly what the robot can do...

https://www.clinicaltrials.gov/ct2/show/NCT05130736?term=balance&recrs=ab&cond=me/cfs&draw=2&rank=2 Recruiting Sponsor: Poznan University of Medical Sciences Collaborators: EGZOTech sp. z o.o.; Szpital Wojewódzki w Poznaniu Condition: Post-viral fatigue syndrome The aim of the study is to...

Existing symptom measuring questionnaires (6 of them) were found to be inadequate: Patient involvement

I'm not sure that the Gottschalk paper particularly joined the dots between mitochondrial dysfunction and the ATG13 in the serum. (They did do a lot of dot joining from the serum to the microglia though.) It's possible that the ATG13 is getting into the serum for a reason unrelated to...

CoQ10 - Coenzyme Q10We have a discussion thread CoQ10. It includes some commentary about this team's earlier work.

Someone let the ginger indirect moxibustion researchers know that there may be some demand for their research skills as the UK acupuncturists seek to diversify. The committee decided that the benefits of acupuncture weren't convincing, given the potential harms, and slammed research that didn't...

I haven't gone through the discussion, but will stop here. There's certainly very interesting stuff, but I get the feeling that, as the study and paper writing went on, everything just got more hurried and less organised. Basic things like how many samples there were for each analysis, and how...

3.6 How might the ATG13 in the serum make microglia produce ROS and Nitric oxide? Off-the shelf ATG13 (i.e. standard stuff, purchased, not from ME/CFS patients) reacts with a type of receptor called RAGE on the microglia to produce ROS and NO. RAGE= Receptor for Advanced Glycation of End...

3.5 The effect of ATG13 in serum on microglia - NO They found something similar with nitric oxide. It looks like they found that nitric oxide produced by microglial cells was increased by exposure to the serum from the initial male case control pair and 8 other case control pairs (I don't know...

3.5 The effect of ATG13 in serum on microglia - ROS No one could accuse these researchers of not covering enough ground in a paper. I think this finding alone would have been worth a paper; I hope the finding is not buried under all the rest. So, in this study, they put human microglia cells...

Back to the paper - Section 3.4 Evaluation of lysosomal function So, they used a protease array to test for lysosomal proteins in the serum. The particular array covered, matrix metalloproteinases, cathepsins, kallikreins (a cool name, a bit like Kali, the goddess of destruction and change...