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  1. Saz94

    Effects of mirthful laughter on pain tolerance: A randomized controlled investigation, 2019, Lapierre et al

    Trish, you should know better! :emoji_wink:Characters in Harry Potter are several times described as laughing mirthlessly. E.g. "‘He’s got Dark powers the rest of us can only dream of!’ Pettigrew shouted shrilly. ‘How else did he get out of there? I suppose He Who Must Not Be Named taught him a...
  2. Saz94

    Effects of mirthful laughter on pain tolerance: A randomized controlled investigation, 2019, Lapierre et al

    How could someone do such a bad study (I'm referring to both the design and the conclusions which they drew). These people surely have a science degree. My degree was only like 25% science, and this paper could have been used as an example of glaringly bad research in, like, one of our first...
  3. Saz94

    Effects of mirthful laughter on pain tolerance: A randomized controlled investigation, 2019, Lapierre et al

    The documentary was boring and they've become more fed up of their pain whilst watching it. Edit: just realised they are healthy patients. OK, so the documentary was so boring that it made them in a bad mood and so less tolerant of pain?
  4. Saz94

    First evidence of immune response targeting brain cells in autism

    Wouldn't you expect living autistic people to then show immune abnormalities in the blood?
  5. Saz94

    PEM for those who are, or were, mild sufferers, how would you describe it?

    Brilliant list. I would add to that: any pre-existing mental health problems becoming worse
  6. Saz94

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    Is that specifically a problem with having an upright MRI, or is that related to the exertion of going to the testing centre and having to sit upright while the scan is done?
  7. Saz94

    PEM for those who are, or were, mild sufferers, how would you describe it?

    To be honest, when I was mild I didn't really have PEM. I mean I could feel worse if I tired myself out but it didn't function like PEM. It sort of went like this: Autumn 2015 (that's northern hemisphere autumn) - fatigue started. Early 2017 - fatigue worsens throughout first half of 2017. By...
  8. Saz94

    Complementary cancer therapies 'do more harm than good' - BBC

    According to that study, we should also avoid eating herring and mackerel. Edit: just read it properly. They're only advising to avoid fish oil and those fish from the day before chemo til the day after. Phew - for a moment there I was worried that I'd need to stop taking my fish oil supplement...
  9. Saz94

    Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

    Sure, but cyclophosphamide is a naaaaasty drug. Obviously if it was found to help people then people would be free to decide whether the benefits were worth the side effects. But I'd be very concerned about it being forced onto children whose parents get to make the decisions for them. Although...
  10. Saz94

    Guardian series: "Blood, sweat and tears"

    The Guardian have a series of perspectives from healthcare professionals. https://www.theguardian.com/society/series/blood-sweat-and-tears
  11. Saz94

    Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

    I am sure some autistic people must have at some point received cyclophosphamide as a cancer treatment. Did it change their autism? If it did, we haven't heard anything about it.
  12. Saz94

    Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

    And that's not even getting started on the questionable scientific validity of mouse autism studies like this...
  13. Saz94

    Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

    The autistic community kinda has the opposite problem as the ME community. The vast majority of autistic people [or rather, of the autistic people who are able to communicate their opinion] want MUCH LESS biomedical research. Some people (mainly the relatives of autistic people) disagree though...
  14. Saz94

    Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

    Taking anti inflammatory drugs such as ibuprofen has never made me less autistic... (Edit: I wasn't taking them in an attempt to be less autistic! Just for the normal reasons that people take ibuprofen!) And I wouldnt want to take a drug with nasty side effects like cyclophosphamide. How about...
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