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With well-defined inclusion criteria (see Andy's comment above mine), the size of the sample does not affect the likelihood of "mish mash" getting in. But, having such a large sample increases the statistical power, which means that the study's findings are less likely to be affected by any...

No it isn't.

Wow there are some really hostile comments on David Tuller's blog about this. Mostly from that small clique of "SPECT scan diagnoses ME" extremists. There's no chance of convincing them about it, but we don't want them to convince other PWME not to participate in the trial. Does anybody have...

Does anyone recognise any of the MP's in the photo?

I'll decide for myself whether or not somebody is gaslighting me, thanks.

Totally agree. We are not helping our cause by jumping on everything that people like TC say when they are not even talking about ME or MUS. It makes us look like the anti-psychology people that they claim we are. But psychology is all well and good when it is being used in the right context.

In an ME facebook group that I'm in, somebody has asked "why can't they use the raw data from the DNA tests that some of us have already paid for? The OMF does." How should I answer that? I know why not, but can't think how to articulate it... damn brain fog.

Some parts of that are definitely true. Trying too hard to be happy is unlikely to make you happy. I know if I go to do something thinking "I want to enjoy this" then I am much less likely to actually enjoy it because I'm too hung up on wanting to enjoy it. And she's quite right to say that...

If only the planet would do the same :cry:

Random question but are you on Twitter as @DrHomeslice? Because some of this sounds familiar.

What medications are those that have changed your experience of PEM? Honestly, what you've described suggests that it's worth investigating whether you may have something else rather than ME, because I don't think that's typical. I don't think I had PEM when I was mild either, then I eventually...

Another thing... Some people will think "well nobody else in my family has ME, so it can't be genetic, so this is pointless research". So it would be good to emphasise that that's not exactly what is meant by genetic research.

Yes that's a really good point, I think the peak of post exertional fatigue is probably a good way to differentiate PEM vs PEF? PEF I'd think the peak ("worst point") would usually be immediately or soon after the exertion, whereas with PEM the peak is between hours to days afterwards.

No worries at all, I wouldn't expect anyone to remember. Frankly it's a miracle that I even remember it myself

Many do get it, but a fair number don't. I ran a poll on this forum about PEM symptoms a few months or so ago.

I understand that the me/cfs biobank questionnaire is being used to check that participants have me/cfs? When I did the biobank questionnaire last year, there was a question like "do you have fatigue that is not relieved by rest?" I think this is not a good question because when I was less...

They can keep saying that, but it won't change the fact that it happened to people.

I'm not sure about that. Doesn't that risk including people who had something else which was misdiagnosed as ME?

But then the population completing the questionnaires is self-selecting and not representative of the cohort participating in the GWAS.

Are those high or low effect sizes? I can't remember how those statistics work :( And can somebody remind me what confidence intervals mean? I understand p-values much more easily, don't like it when papers use confidence intervals instead. And what does I2 mean??