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    Michael Sharpe skewered by @JohntheJack on Twitter

    That’s one of the possibilities I was alluding to – but I didn’t want to make myself look like a prat if it was a ridiculous suggestion. @Lucibee, who is much more knowledgeable than me, seemed to think it was more innocent that I was implying. Any thoughts @Jonathan Edwards @dave30th @Carolyn...
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    Michael Sharpe skewered by @JohntheJack on Twitter

    I thought it might be useful (and quite amusing) to put screenshots of some of Michael Sharpe’s “have you read the paper?” Tweets together in one place. Carol Monaghan, MP and former head of science: @Carolyn Wilshire, PhD, lead author of the 2018 PACE reanalysis: @Mike Godwin, lawyer...
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    Michael Sharpe skewered by @JohntheJack on Twitter

    I’m sure this is true. Further to my previous comment, I would add that I would have been much more likely to volunteer in the earlier stages of my illness (year 1 or 2) than later on. It was clear early on that exertion made me worse but again and again I refused to accept/believe it. In...
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    David Tuller: Trial by Error: Sir Simon Scores an Own Goal

    Yes, that I have been laughing so much (despite feeling like sh*t) is another sure sign that we are winning. Here’s where the Godwin/Sharpe/Weesly Tweets start in the S4ME discussion for anyone whose not been following...
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    Michael Sharpe skewered by @JohntheJack on Twitter

    Wessely seems very anxious to assure us that he was not an author, when, as Keith points out, nobody has suggested he was. I’m not sure if this is, as Keith suggests, a diversionary tactic or whether there may be more too it. Wessely’s own tweets suggest that he probably should have been an...
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    Michael Sharpe skewered by @JohntheJack on Twitter

    Would it be easier to start a new thread just for uploading the screenshots? Then you could just upload them as jpegs.
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    Michael Sharpe skewered by @JohntheJack on Twitter

    If they are deleted on Twitter (by the Tweeter) they will disappear from here as they are only embedded. It would be wise to save screenshots of the ones you feel are most important. [Edit: would anyone like to take responsibility for saving screenshots of important Twitter threads and...
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    Michael Sharpe skewered by @JohntheJack on Twitter

    I am tempted to ask if MS has actually read the paper.
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    Michael Sharpe skewered by @JohntheJack on Twitter

    One needs to distinguish between a clinical trial and treatment in clinical practice. I might be willing to subject myself to a treatment which I believe is ineffective and potentially harmful in a clinical trial if I felt it would help to advance the understanding of my condition. But I would...
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    Michael Sharpe skewered by @JohntheJack on Twitter

    I know this seems pedantic but precision of language is important, as the PACE/BPS crowd so often pick up on it as a way to divert from the valid criticisms of their research. As far as I’m aware – and as Sharpe has pointed out on Twitter – the PACE authors do not refer to “false beliefs”. They...
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    Michael Sharpe skewered by @JohntheJack on Twitter

    This was a post three days ago, before I prodded Godwin to reply to Sharpe’s tweet... Wessely is too savvy to get into a public fight with an old friend who happens to think his beloved trial is a pile of crap. The probability that Sharpe would provoke a skirmish was always much higher. I’m...
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    Michael Sharpe skewered by @JohntheJack on Twitter

    For those not on Twitter, or not following:
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    Michael Sharpe skewered by @JohntheJack on Twitter

    I don’t think you can pm on Twitter unless the person follows you. Ask Omar. He knows Godwin from school and has his email address.
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    Michael Sharpe skewered by @JohntheJack on Twitter

    Godwin responds to Sharpe:
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    Michael Sharpe skewered by @JohntheJack on Twitter

    Important to note that Godwin’s Law makes no judgement about the appropriateness of references to Hitler. It was just an observation that “As an online discussion grows longer, the probability of a comparison involving Hitler approaches 1.” If I was feeling a bit better I would write more about...
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    Analysis of data from 500k individuals in UK Biobank shows an inherited component to ME/CFS (Ponting blog)

    That sounds very like a tautology to me. The UK Biobank study found what it had the power to find, as would any study with any number of participants. I’m not sure I understand the second bit. Are we not discussing separate genetic contributions to a disease? Let’s assume 5% of the 0.445% (for...
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    Michael Sharpe skewered by @JohntheJack on Twitter

    I think he means independent in the same way that Cochrane is independent. For anyone who is not aware, in 2106, giving evidence under oath in defence of QMUL, Chalder stated: “disclosure to the Cochrane review does not count as disclosure to independent scientists as all three of the PACE...
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    Michael Sharpe skewered by @JohntheJack on Twitter

    Yes, I think that’s what happened. And Godwin seems to have realised that too. I agree. It would be unfortunate if Godwin was deterred from further engagement/involvement. He is clearly interested and appears to have taken in a great deal of information (which he requested) in a very short...
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    Michael Sharpe skewered by @JohntheJack on Twitter

    Mike continued... “None of the foregoing is a defense of the PACE trial, which, based on my current understanding, seems so profoundly flawed that it cannot be trusted. Nor is it a defense of researchers who should have been more rigorous. But humility is good practice for all of us, and ...
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    Michael Sharpe skewered by @JohntheJack on Twitter

    @Mike Godwin continued (apologies if I’ve got these tweets in wrong order): “I think humility is good for everyone, generally speaking. There are many medical conditions whose aetiology is mysterious or at least ambiguous. Symptoms, and strategies for treating the symptoms, may vary among...
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