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Also interesting is that PNES frequently occurs in patients who have epileptic seizures. See for example: read://https_www.ncbi.nlm.nih.gov/?url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5862101%2F Soo patients with epileptic seizures frequently have this mysterious psychiatric...

And here's a Cochrane review from 2014 on psychological and behavioral interventions for patients with PNES. It concludes: There was a randomized trial of CBT by Goldstein et al. 2010 that initially reported benefit but the differences were no longer statistically significant at follow-up.

Here's a systematic review of surveys of patients with 'psychogenic non-epileptic seizures'. What patients say about living with psychogenic nonepileptic seizures: A systematic synthesis of qualitative studies - PubMed (nih.gov) It concludes: This message is repeated throughout the paper:

So if I understand correctly, this preliminary study tested 4790 unique human proteins in a small sample of 20 ME/CFS patients and 20 controls. After controlling for multiple testing, 9 proteins showed statistically significant differences between the two groups. These are summarized as...

Here are some of the main conclusions:

The review is quite long: here are some interesting quotes:

Psychological and psychiatric aspects of psychogenic non-epileptic seizures (PNES): A systematic review - PubMed (nih.gov) I thought this review from 2016 of Psychogenic non-epileptic seizures (PNES) was quite interesting because it suggests we know very little about this condition and that the...

Thought this was interesting: Do we belittle epilepsy by calling it a disorder rather than a disease? - PubMed (nih.gov)

The authors suggest considering problems with connective tissue (joint hypermobility), small fibre neuropathy, mast cell activation in patients with pain and fatigue. On the hand, they propose a multidisciplinary model based on the biopsychosocial approach and referral to a health psychologist...

Excellent @Caroline Struthers

Yes oops. Thanks for noting. Corrected it:

They did a systematic review of systematic reviews without reviewing the actual trials. (This wasn't intended as a joke, it's actually what they have done). The effect size across these reviews seems to be quite small not modest (0.23 standard deviation). If they looked at studies that used an...

Rather than providing evidence to support the effectiveness of CBT, I think the authors have accidentally done just the opposite.

This Belgian article was featured in the press: Biologisch mechanisme dat prikkelbaredarmsyndroom veroorzaakt ontrafeld | EOS Wetenschap Onderzoekers KU Leuven ontdekken mechanisme dat prikkelbaredarmsyndroom veroorzaakt | VRT NWS: nieuws If I understand correctly, the authors think that IBS...

Thanks for clarifying. There are quite a lot of proponents of behavioural interventions for ME/CFS in the guideline development group, so your testimony must have made quite an impression.

I wonder how much influence Jonathan's excellent testimony had an influence on the grading of GET/CBT trials as low to very low-quality evidence. Because his testimony was before the guideline development group but the summary and grading of evidence was prepared by other people if I understand...

If other people have a better view of this issue I'd be interested to read their books or articles. Reading tips are always welcome.

But if everybody knows about this, how come there are still little randomized-placebo-controlled trials for surgical interventions and why are many surgeons still performing the ones that haven't been tested or have been shown in RCT to be ineffective? I can't vouch for Harris his judgement but...