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Why restrict it to illness? I'm reprogramming my genes with my mind to become a were-panthera as we speak.

I don't think it is quite that simple, because not all ex-poliomyelitis patients develop it. The delay for decades isn't fully explained by the "overuse" explanation, nor the fact that electrodiagnostic methods have inconsistent results. I wonder if there is more to it than the notion of natural...

No, they're simply skirting around what they really believe - that it is all in the brain. The pain reference is a thinly veiled reference to central sensitisation. There has been a consistent finding in the 10 studies that studied the phenomena and Norman Swan is probably completely unaware of...

Wait, what is he saying? That he's going to pursue a political career in the USA? (I'm having trouble reading between the lines)

I have commented, even on the thread about Systrom's most recent study. https://www.s4me.info/threads/unexplained-exertional-intolerance-associated-with-impaired-systemic-oxygen-extraction-2019-by-melamed-systrom-et-al.11176 I am not a fan of his methodology, as they are ignoring the first...

I don't have a a problem with simplicity of unoriginality, if it's actually true. The part I don't understand is why he continues to believe such a hypothesis when his own studies contradict it.

No idea, it's a radio show so we'll never know!

I suspect they'll have a certain guest from UNSW.

It's hard to say as the trials don't have that many people infected in the vaccine arms to form strong conclusions. It is also compounded by premorbid conditions and other risk factors - those who are likely to get COVID19, despite being vaccinated may have risk factors that also predispose them...

I'm keen to read this once I have access. Note that an increase in conduction velocity is often associated with increased temperature. Which suggests that patients could be working (relatively) harder than controls. (note, I'm assuming factors like muscle fibre length are effectively...

One key point is that if a few people call out a questionable statement, it can often be helpful, but if 50 people join in, it becomes a pile-on and those who believe such questionable statements tend to double-down. I suspect it is the quantity of comments that has led TG to choose the option...

This is tricky to do as biopsies aren't the easiest to take and when you do take them, the tissue can get damaged.

Patents are horrible to read so I'll pass on that! I am kind of glad they have patented this as a patent by the wrong people could hold up progress... As for biotin, it's commonly used in bionanotechnology with Avidin to stick things together.

The common patterns between ciguatera and ME are interesting, multiple underlying causes with commonalities in the end point. The study (in the OP) is less compelling because it is based on cell culture of mice neurons, rather than human patients and I am interested in the interactions on a...

Defining the role of asymptomatic and pre-symptomatic SARS-CoV-2 transmission – a living systematic review https://www.sciencedirect.com/science/article/abs/pii/S1198743X21000380 So (reported) asymptomatic cases are around 85-90% less likely to transmit the virus to someone else given the...

The problem is that severity may simply be a confounding factor - those with more severe illness have different sleep-wake patterns, namely they sleep more and are less active in the morning. Studies may indeed find a difference, but it might not be at all relevant. It is important not to...

Aptamers are really cool, I had to study them for my undergraduate degree over 10 years ago. The key is to have an off-the-shelf kit with validated sensitivity/specificity. (which is not perfect BTW, this is primarily a discovery tool) The set of aptamers has only been commercially available...

The HPA axis stuff was the hottest/most studied hypothesis back in the 90s and early 2000s and pulsatility of pituritary gland secretions has already been studied. 24 hour profile of cortisol, corticotropin (ACTH), growth hormone and prolactin...

I presume you are referring to sensitive blood based biomarker tests. We do have a good candidate for a reliable biomarker (in over 10 studies): workrate at ventilatory threshold on the 2 Day CPET. The only problem is that it isn't practical for many patients to undergo. All of this still...

Of course this is not the same as LongCovid - some of the people with dyspnea or ageusia might not have the other most common LongCovid symptoms (fatigue, headache, brainfog).