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  1. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    Another medical doctor who rarely if ever read epidemiological literature before COVID-19 the literature and believes the elite-group think that somehow far more people have been infected than measured. The sensitivity of the serological tests is somewhere around 90%, meaning around 10% of...
  2. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    On this topic, several groups are developing monoclonal antibodies (often treatments combining several), which may be brought to market at around the same time as vaccines.
  3. Snow Leopard

    Effectiveness of an ACT‐based rehabilitation program for the treatment of chronic fatigue: Results from a 12‐months longitudinal study, 2020, Brugnera

    I would have liked to see a scatter plot of hours worked vs change in hours worked, but alas this was not done. I mean it wasn't as if return to work was the primary outcome of the treatment. Oh wait, it was! Hmm...
  4. Snow Leopard

    Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans. Thapaliya et al. 2020

    I'm still trying to work it out. The diagram is suggesting lower ferric->ferrous conversion (STEAP3), it is implying lower uptake by TfR1 & DMT1, but no data for DMT1 or TfR1 was provided, so this lowered uptake is assumed to be due to imparied vesicle endocytosis. The last diagram implies lower...
  5. Snow Leopard

    Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection July 2020 Townsend et al

    Impossible to say right now, because the medical authorities haven't bothered to keep track.
  6. Snow Leopard

    Pain catastrophizing is associated with the Val66Met polymorphism of the brain-derived neurotrophic factor in fibromyalgia, da Silveira Alves , 2020

    More candidate gene association junk. Unless the SNP is highly specific (100% of cases as in rare genetic diseases), I just don't care.
  7. Snow Leopard

    Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection July 2020 Townsend et al

    On the contrary to the authors claims, an unexpectedly low number (1.6% compared to population norms) of depression/anxiety was associated with an absence of caseness. In fact diagnoses in both groups were below Irish norms, agreeing with your hypothesis of participation bias...
  8. Snow Leopard

    Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans. Thapaliya et al. 2020

    This study is novel in that the active MRI tasks was the stroop test. The magnitude of the observed effect may suggest that this is a consequence, rather than a cause of the dysfunction in ME. Notably the T1w/T2w artifacts were noted to be in the opposite direction as observed in multiple...
  9. Snow Leopard

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    As I posted on the SW thread, the incidence numbers were significantly lower than what we've seen from SARS-2 (or EBV for that matter). 227 reported cases for 113,979 influenza diagnoses (though only 13054 cases were laboratory-confirmed).
  10. Snow Leopard

    Fatigue measurement scales

    Yes, there is a total lack of clarity, or blurring of what is actually being measured. Fatigue usually means many different things when it comes to these questionnaires, but those who use them do not care about specificity. Similarly, the measures of "validity" are very superficial (and usually...
  11. Snow Leopard

    Objective assessment of diverse types of MS related fatigue and fatiguability

    The "metacongition" stuff is merely speculation. The authors don't seem to understand, nor care about how peripheral efferents are directly coupled with central drive through the spinal column. No magical (meta) brain interaction is necessary (or likely). The authors are probably confused by...
  12. Snow Leopard

    Massachusetts ME/CFS & FM Association launching Research Club Support Group on Zoom this month

    Has anyone participated in one of these meetings? I'm curious about the level of engagement with the audience / interesting questions being asked?
  13. Snow Leopard

    Coronavirus - worldwide spread and control

    Do you agree with these restrictions, including the curfew? https://www.abc.net.au/news/2020-08-02/victorias-latest-coronavirus-restrictions-explained/12516182 I suspect the surge in Victoria was due to non-compliance with existing restrictions, rather than a lack of restriction severity...
  14. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    How does he know he had a cytokine storm when is cytokine levels weren't measured? He was also taking an IL-6 inhibitor, suggesting that something other than a cytokine storm was going on. Cytokine storms are not simply high levels of inflammation, they are a specific condition. So far...
  15. Snow Leopard

    Occupational therapy consensus recommendations for functional neurological disorder, 2020, Stone et al

    The type where they ignore the wishes of the patient and insist their rigid plan has efficacy despite a lack of objective empirical evidence. Proposed interventions: Focusing on their hypothesised perpetuating factors:
  16. Snow Leopard

    BPS attempts at psychologizing Long Covid

    It's like watching a trainwreck in slow motion.
  17. Snow Leopard

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    https://www.sciencemag.org/news/2020/07/brain-fog-heart-damage-covid-19-s-lingering-problems-alarm-scientists Who was it who said the more symptoms a patient reports, the more likely psychological factors are involved in perpetuation of the illness?
  18. Snow Leopard

    Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection July 2020 Townsend et al

    I think they were already using the CFQ in their clinic and this is just a rushed study...
  19. Snow Leopard

    Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection July 2020 Townsend et al

    Depression/Anxiety was based on prior diagnoses or use of antidepressant medication. The real problem is that caseness was based on the aforementioned crap questionnaire. Notably, 86.6% of "Fatigued" participants did not have any prior depression/anxiety diagnoses, so this a weak predictor at...
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