Association between long COVID and nonsteroidal anti-inflammatory drug use by patients with acute-phase COVID-19: A nationwide Korea National Health Insurance Service cohort study
Ye-Seul Lee, Heejun Kim, Sunoh Kwon, Tae-Hun Kim
Introduction
Long coronavirus disease (COVID) poses a significant...
I'd like to see a study that looks at people who get sore throats during PEM and does throat swabs before and after exercise to see what information can be obtained, including markers of inflammation and existence of pathogens.
I'm not sure I feel comfortable advocating for more studies...
Depressive disorder; clinical correlates and Tumor Necrosis Factor alpha among post COVID-19 patients
Aya Mohamed Khaled Sakr, Tarek Ahmed Okasha, Marwa Abd El-Meguid, Maha Mohamed Sayed, Mariam Yehia Mohamed
Background
COVID-19 infection is known to trigger a significant inflammatory response...
Heart rate variability is not associated with multiple chemical sensitivity in a cross-sectional population-based study-The Danish study of functional disorders
Anne Ahrendt Bjerregaard, Louise Brinth, Marie W Petersen, Signe U Schovsbo, Lene Eplov, Susanne Brix, Allan Linneberg, Lise Gormsen...
Insights into the Risk Factors and Outcomes of Post-COVID-19 Syndrome—Results from a Retrospective, Cross-Sectional Study in Romania
Ioana Beja, Corneliu Petru Popescu, Simona Maria Ruta
Abstract
Post-Coronavirus Disease 2019 (post-COVID-19) syndrome represents a cluster of persistent symptoms...
Long-/Post-COVID symptoms in a hotspot collective of the first wave of the SARS-CoV-2 pandemic in Germany
Anna Wolfschmidt, Stephan Ott, Steffi Richter, Johannes Schmidt, Wolfgang Uter, Hans Drexler, Thomas Finkenzeller
Introduction
Despite a high number of long/post-COVID cases and an...
One thing I realized should be kept in mind, is a lot of these groups collaborate so there is some overlap in participants in different studies, for example John Wherry is apparently using the cohort from Iwasaki's lab and the cohort from Peluso/Henrich's lab, and these researchers all have...
I mean evidence of COVID persisting in LC using different methods and in different cohorts is something, right? At least gives a general idea of where to go next.
If the huge difference in megakaryocyte persistence is found to be real or possibly made more sensitive, that seems like basically a...
1:52:30 John Wherry–T cells as biosensors in Long COVID
Main takeaways: Wherry's lab is experimenting with looking at levels of T cells specific to certain antigens, such as SARS-CoV-2, as sensors which likely imply presence of these antigens. They are looking at these levels in acute...
The first citations I decided to look at have no relevance to the sentence they follow. Neither one mentions stem cells.
Jason, L. A., & Sunnquist, M. (2018). The development of the DePaul Symptom Questionnaire: Original, expanded, brief, and pediatric versions. Frontiers in Pediatrics, 6...
1:41:42 Akiko Iwasaki–Probing the Role of Endogenous and Latent Viruses in Long COVID
Main Takeaways: Iwasaki's lab is studying latent viruses' (including EBV and endogenous retroviruses) potential involvement in various diseases. They have found that endogenous retrovirus expression is...
1:30:09 Michela Locci–Lymph Node Immune Responses in Long COVID
Main takeaways: This group has found differences in germinal center B cells (GC is involved in selecting and proliferating the best B cells) in long COVID. As opposed to controls, where proportion of B cells specific to SARS-CoV-2...
Glad it's helpful! Definitely might take longer than I thought to get through all of these though, my brain was barely functioning last night after doing a few.
It looks like there was early evidence cytokine changes with PEM here:
Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (2018) Montoya et al. (Thread)
Edit: Also, Sex-Dependent Transcriptional Changes in Response...
Oh yeah, thanks that's very cool. My idea wasn't working very well, probably because the difference in my face was way too small for it to be picked up by a camera and/or the ML model.
But I'm still always trying to think of a similar concept that might work - training with data before and...
1:17:35 Marcus Buggert–LymphPASC Project Proposal: Exploring Lymphoid Immune Activation in Post Acute COVID-19
Main takeaways: Ongoing study trying to see if SARS-CoV-2 persists in gut and tonsils, and seeing if persistence leads to T cell activation in tonsils. Another ongoing study is looking...
1:02:57 Johan Van Weyenburg–Blood transcriptomics reveal persistent SARS-CoV-2 RNA as a candidate biomarker, a real world Long COVID cohort
Main takeaways: Performed blood transcriptomics on LC patients (looking at circulating RNA to see what proteins are currently being produced by both human...
39:03 Resia Pretorius–Microclots, Biofilms and NETs: optimizing methods for biomarker identification
Honestly, this one was very confusing so I probably missed a lot of relevant details, so watch it if you are interested in microclots.
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Goal: Identify...
27:16 David Price–Infectious, Immune and Microbiome Signals in the Long COVID Lung
Main takeaways: In long COVID: SARS-CoV-2 specific T cells more inhibited - potentially indicates ongoing exposure. Lower SARS-CoV-2 neutralizing antibody activity - potentially allows virus to proliferate...
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