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I am seeing this narrative a lot just recently. Is it me or is this completely ar** over t*t. When clinicians are unable to diagnose disease or correlate symptoms with measurable changes in biomarkers, patients experiencing such an illness are at increased risk for suspicion, misplaced...

I can understand the desire for a public enquiry but maybe it is worth warning people that it might produce the opposite of the desired effect. If an enquiry is set up by sympathetic people and advised by sympathetic people it will simply be dismissed as further activism. It will go the way of...

All together now. Oh yes it does... I didn't like the results because they truncated the Y axis and there is only one reason to truncate a Y axis folks.

But signatures could be collected over several good days. I would place a bet that you could get 500 signatures with a bit of effort.

I think a letter from s4me with 2000 members signatures might be more on the nail. In a sense professionals querying editorial decisions is counter to the concept of peer review with editorial freedom. you go round in circles. But 2000 patients complaining about poor editorial policy might wake...

Maybe there should be a letter from S4ME with 2000 members signatures. A letter to the editor is not going to solve an me/cfs professional organisation running a journal with a poor editorial policy but it would be a start.

I am not sure that these people believe anything. They see that following a fashion is their best way to get ahead. They very much give the impression that they do not have any ability to judge what is true and what is not so work on the principle that it doesn't matter. I have come to think...

This is the salient problem. I agree with Michiel in principle but reality has trumped theory.

Maybe it should have read: A review of the NICE guidance is currently underway (revised guidelines are due to be published in late 2021) [9]. Both CBT-F and LP were judged to be unsuitable for use. There is a clear need to improve treatments for paediatric CFS/ME.

No, I think your analysis is right. A non-vaccinated person must be a better variant factory than the same person vaccinated. The idea of 'evolutionary pressure' is bogus. Mutation is inherent to the DNA and the host cell replication machinery. Pressure does not increase it. If there is...

I don't know why it should though.

Two opinions. Neither is an immunologist and this is immunology. I don't think we have reason to think autoantibodies are of any importance in ME, whether primary or secondary whatever that might mean.

If there is something specific to say or to establish that has not already been said or established I can see PR being useful. The problem for me comes with the introduction of 'ME, the complex, multi systemic neuroimmune disease'. To change the narrative usefully it needs to change from that...

I fail to understand how this is a paper. they looked at two treatments and noted they were a bit different - that seems to be all it says. Surely the fact that two treatments are a bit different is there for anyone to note? And where did CBT-F come from?

That does not quite fit with the way things are presented in the video.

Something I had wondered about but not investigated is whether or not the mouse studies were done in a blinded and systematic way, which would be essential for a reliable result. Listening to the video by David Anderson it seems not. They tested one patient and one control, I suspect knowing...

I am not sure I know what that would mean. I suspect the people diagnosing it might say yes but I couldn't be sure. presumably it would imply a uniform mechanism that is not present otherwise. I find it hard to see that as likely since physicians cannot agree how many people to include.

So what is 'characteristic of fibromyalgia'? It all seems pretty vague to me. If it really was characteristic and easy to discriminate then why do physicians find it so hard to agree on who has it? I have looked after people with painful peripheral neuropathy and it is immediately obvious...

Rather than playing with mice I would concentrate on establishing the validity of the claim to autoantibodies being present. I would ask Angela Vincent to get her colleagues to repeat the immunochemical/cytological studies and see if they hold up. I have not had time to look at the paper in...

I understand your problem @Trish . I am not dismissing the research but expressing my opinion that it is very unlikely to hold up. It is difficult to give precise reasons but there are at least half a dozen things in this study that tome indicate that the authors do not really grasp the...