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  1. J

    Livestream: Ron Davis to speak at Columbia University

    So this is at Albert Einstein COM not Columbia http://www.einstein.yu.edu/departments/genetics/calendar/?cMonth=8&cYear=2241 (only of interest because I could attend IRL)
  2. J

    Livestream: Ron Davis to speak at Columbia University

    Wait....Albert Einstein COM is not part of Columbia.... wonder where this is https://en.m.wikipedia.org/wiki/Albert_Einstein_College_of_Medicine
  3. J

    Cyclophosphamide

    Lactobionic Acid Conjugated Quercetin Loaded Organically Modified Silica Nanoparticles Mitigates Cyclophosphamide Induced Hepatocytotoxicity https://www.dovepress.com/lactobionic-acid-conjugated-quercetin-loaded-organically-modified-sili-peer-reviewed-article-IJN
  4. J

    Alzheimer's Trial: Lessons From a Failed Drug — What the pragmatic trial of minocycline can teach us

    https://www.medpagetoday.com/neurology/alzheimersdisease/83410 mentions microglia inflammation. Cheap trial *only* cost $2 million.
  5. J

    Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

    They also used minocycline successfully on the mice.
  6. J

    Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

    Also highlighted here in Science Translational Medicine “A no-nonsense treatment for autism spectrum disorder” https://stm.sciencemag.org/content/11/516/eaaz3723
  7. J

    Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

    https://www.cell.com/neuron/pdfExtended/S0896-6273(19)30733-0 Used cyclophosphamide to treat autism symptoms in mice by reducing brain inflammation.
  8. J

    Ron Davis’s big immune study is looking at HLA genes (HLA, WTF?) Here’s the story. [Simon M blog]

    @deleder2k thanks. I imagine the Fluge paper is about to come out? Why am I nervous? It’s associated with psoriasis. https://www.frontiersin.org/articles/10.3389/fimmu.2018.00954/full
  9. J

    Differentiating post-polio syndrome from myalgic encephalomyelitis and chronic fatigue syndrome, 2019, Jason et al

    This abstract looks pretty worthless. They define three things, "PPS", "ME" and "CFS" in the background section. Then, under results, they compared "ME/CFS", which wasn't defined in the background section to PPS. Wow, this journal article must have undergone severe peer review. Sometimes it...
  10. J

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    In general, to me, this thread does not seem to be very useful or rewarding. It seems to be degenerating into some type of tribal dispute. If you don't want the CCI operation, then please, by all means, don't have one. If people want the operation with INFORMED CONSENT, then power to them...
  11. J

    Golden hour (/month)

    so far, more like the lead, arsenic, plutonium month.....
  12. J

    Golden hour (/month)

    nope, no golden month for me in November....I could always hope that it hits in late November.....
  13. J

    Mild sleep apnea

    I started having medium, not mild, sleep apnea maybe a year prior to the point of no return of my MECFS. I hadn’t had any apnea prior to this. I got a CPAP machine but I didn’t feel any better after using it, so I stopped using it. I believe the underlying MECFS causes the sleep disturbances...
  14. J

    Innovative Drugs Save Lives Only if People Can Afford Them, NYT

    https://www.nytimes.com/2019/11/02/opinion/sunday/pelosi-drug-prices-plan.html?action=click&module=Opinion&pgtype=Homepage
  15. J

    News and views in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): The role of co-morbidity and novel treatments (2019) Comhaire et al.

    @Badpack Comhaire posts here under the name “ME/CFS”. You could @ him if you have questions. Meldonium is available online... not so expensive.
  16. J

    News and views in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): The role of co-morbidity and novel treatments (2019) Comhaire et al.

    Thanks for posting. I know many are negative on Comhaire’s work, but at least he is investigating some potential treatment options.
  17. J

    Long-awaited cystic fibrosis drug could turn deadly disease into a manageable condition

    https://www.washingtonpost.com/national/health-science/in-hunt-for-new-treatments-nonprofits-are-acting-like-venture-capitalists/2015/07/02/c6094578-19b8-11e5-93b7-5eddc056ad8a_story.html This is the article that is linked to in the above article.... these guys were able to raise a ton of money...
  18. J

    Long-awaited cystic fibrosis drug could turn deadly disease into a manageable condition

    Congrats...but it took 30 years from ID’ing genetic defect to the development of a robust treatment. https://www.washingtonpost.com/health/2019/10/31/long-awaited-cystic-fibrosis-drug-could-turn-deadly-disease-into-manageable-condition/
  19. J

    "Positive Health Statement" - Job Centre Plus

    Merged thread I'm Broken, Britain: The DWP tells us to self-censor our own disability https://www.politics.co.uk/comment-analysis/2019/10/28/i-m-broken-britain-the-dwp-tells-us-to-self-censor-our-own-d has ME
  20. J

    Intra brainstem connectivity is impaired in chronic fatigue syndrome, Barnden et al., 2019

    No need to open and replace anymore. https://www.medicalnewstoday.com/articles/241215.php
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