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Dear @Hutan I honestly think you are being overly critical here...~50% reduction in fatigue and brain fog is pretty significant.... But this is your opinion...it is not mine. There are several patient reports of people going from severe/very severe (like bed bound in dark rooms) to moderate...

To clarify a bit, the Abilify itself causes weight gain—this is a side effect.

An alternative explanation is that aripiprazole is actually effective at treating the symptoms of MECFS. Authors don’t claim this a RCT study. Weight gain is a side effect of antipsychotics so actually surprised weight gain was rather low.

The main challenge will be how to overcome tolerance/tachyphlaxis/ poop-out.

Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole...

OSU 6162 is a partial D2 agonist similar to Abilify. Probably something here. Would like to see a longer study to see if tolerance/tachyphlaxis develops. https://en.m.wikipedia.org/wiki/OSU-6162

Silent no more...

Senior author https://en.m.wikipedia.org/wiki/Eric_Schadt

A lot of work just to make the visualization animations.

I’m waiting for my @Simon M explainer....Didn’t know that Mt.Sinai had a group working on this.

We’re druggable! Also too early in the process for them to cover Abilify. First I’ve heard of Myelophil. https://www.frontiersin.org/articles/10.3389/fphar.2019.00991/full

I support OMF—with many researchers and centers they are most likely to make a breakthrough.

Review article.

Moved post Whitney not sleeping well due to Abilify.

Not cheap. https://www.fiercepharma.com/sales-and-marketing/j-j-undercuts-celgene-s-pomalyst-135k-per-year-darzalex-price

https://www.insideedition.com/drew-pinsky-among-covid-19-long-haulers-with-lingering-symptoms-i-am-forced-to-lie-down-every-hour Drew Pinsky Among COVID-19 ‘Long Haulers’ With Lingering Symptoms: ‘I Am Forced to Lie Down Every Hour or Two'

Might be reversible somewhat. A bunch of us got a lot of relief from Abilify—Martin (paused_me) went from severe bedbound to going to work. I don’t think you would get a similar response in MS from any of their meds. I agree with the discussion of PEM. I’m not really much an acute PEM person...

I’ve mentioned this before but it would be helpful if OMF put out an official quarterly or biannual newsletter. Something short would be fine.

I have a feeling that OMF might be closing in on a biomarker. But if there is a biomarker and it reflects something downstream, is it possible that the biomarker might not be useful in identifying treatments? Are there examples of other diseases where a biomarker was found, but it was not...