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I think you are underestimating the work involved. You also have to come up with an acronym that hasn't been used before.

Either that, or they have shares in a company planning to import and sell the transcutaneous electrical acupoint stimulation machines, and they needed a 'scientifically proven' paper in English to support the marketing...

How interesting. It is pretty good, especially when we consider the NICE/SIGN/RACGP post-Covid-19 syndrome guideline it is based on. It's good to see a picture of a health care worker looking exhausted, and mention of how GPs have themselves suffered with post-Covid-19 symptoms and have not...

I do find it encouraging that my idea of good answers to the question of how could NICE improve its guidance (answers which are aligned with the thoughts of many of us here) are regarded by NICE as worth talking about.

This is such a bad paper. It's only in a table that you find out the numbers of children involved: the study involved 10 children with recurrent abdominal pain and 17 children with asymptomatic gut parasite infections. The paper seems to suggest, with absolutely no evidence, that the children...

As @rvallee notes, the Strengths and weaknesses questionnaire that supposedly tells us if a child has ' psychological problems' asks if the child 'complains of stomach-aches'. The resulting score is provided as evidence that children complaining of stomach aches have psychological problems.

Oddly, I have been asked to spend an hour online with a NICE representative discussing the topic of the survey. The call will be later in my day; tomorrow morning UK time. If people have more views about this topic, please do post on this thread today.

I especially liked the questions about stress. Because, even if the patient has had the extraordinary good fortune to have had no stress in their life, the current situation of reporting their physical symptoms to this patronising doctor and being told it's a stress reaction must certainly...

In favour of the term, it would allow us to refer to the promoters of the idea collectively as the 'presss gang' which seems a whole lot more appropriate than the 'muppets', or even the 'BPS crowd'.

A post about Michael VanElzakker's recent video about sickness behaviour and glial activation has been moved: Michael VanElzakker

Responding to a deleted post Doctors don't seem to be interested. My record of lab tests doesn't have any complement-related tests, but I've been slack about copying results into it these last couple of years. I don't recall any complement-related tests.

Responding to a deleted post Thank you, that's really interesting. My son and I get generalised swelling when in PEM - I don't wear rings, and lately now don't wear my watch either for that reason. There is facial swelling too, around the eyes. My son has had a couple of episodes of very...

It's not clear to me what that slide is suggesting. That exercise and anti-C1q antibodies reduce levels of functioning C1q? So C1q can't do it's job helping to defeat pathogens and clear the rubbish up? But, I don't think we have any evidence of high levels of Anti-C1Q antibodies in ME/CFS...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583111/ Abstract Complement activation resulting in significant increases of C4a split product may be a marker of postexertional malaise in individuals with chronic fatigue syndrome (CFS). This study focused on identification of the transcriptional...

I've made a thread for a Sorensen paper from 2003 here: Complement activation in a model of chronic fatigue syndrome, 2003, Sorensen et al It's an interesting paper with an exercise challenge. It looks as though they tested C1Q and did not find a significant difference - but I couldn't find...

Published in 2003 https://www.jacionline.org/article/S0091-6749(03)01546-X/fulltext Abstract Background: A need exists to identify biological markers in chronic fatigue syndrome (CFS). Objective: To use an exercise and/or allergen challenge to induce the symptoms of CFS and to identify a...

Is the level of elevation of the C1Q significant? The unit of measure in this study is miligrams/dL. (1 mg/dL =10 ug/ml) This study suggested the normal range is 10 to 25 mg/dL. Mayo clinic's normal range is 12 -22 mg/dL. Using that range, most of this study population have high C1Q...

So C1Q - thanks to wikipedia, this is my understanding, which may be wrong and will certainly be incomplete, so do correct me: 1. CIQ binds to molecules that suggest the immune system needs to do something C1Q can bind directly to bacterial and viral surface proteins, dying cells, and...

We have set up a separate thread for people to express their sympathy for Hilda and her family regarding this very sad news: In Memory thread: Condolences to Hilda Bastian on the loss of her son

Complement factor C1Q The main finding of interest though was the high levels of C1q.