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I have made some comments and provide some excerpts from Tyson's 'The vicious cycle...' paper here: The vicious cycle of [FND]s: a synthesis of healthcare professionals’ views on working with patients, 2020, Barnett et al The authors see FNDs as psychogenic, that is, conversion disorder. The...

This is all dyed-in-the wool, BPS play book stuff. We see these points repeatedly in papers as FND proponents wring their hands about how better ways of giving and explaining the diagnosis have to be found. And, that's not surprising as this paper is a review of papers examining health care...

FND is clearly conceptualised as psychogenic. Using metaphors to describe the illness and being confident in the diagnosis are regarded as "Successful techniques for treatment". Unnecessary testing should be avoided, as should referrals There's a clear view presented that FND diagnosis is...

From the introduction: It seems the authors, including Sarah Tyson and the Masters student that she was mentoring, believe that misdiagnosis of FNDs are a rare occurrence and that people should be confident that FNDs can be diagnosed accurately. The authors suggest that clinician uncertainty...

If it was that, that would be ok. But it also calls for this in a situation where actually no one knows enough to provide any guidance. Feelings of uncertainty in the clinician are the main protection a person with disease that can't be cured by happy thoughts has against an inappropriate FND...

A member has reminded us that Professor Sarah Tyson has co-authored publications on FND. The vicious cycle of functional neurological disorders: a synthesis of healthcare professionals’ views on working with patients with functional neurological disorder We have a thread on the first one here...

This post has been copied and following discussion of FND moved from: UK:ME Association funds research for a new clinical assessment toolkit in NHS ME/CFS specialist services, 2023 A member has reminded us that Professor Sarah Tyson has co-authored publications on FND. The vicious cycle of...

Yes, me too.

Top differentially expressed genes Fig 4 looks a bit more exciting. The heat map is the difference between each group versus the mean of the other three groups. They say that the only significant differences were the 13 gene expressions different between the SARS+F+ and the rest. And the...

PCA analysis The PCA is in Figure 2 - there's no separation of any of the groups, despite the axes accounting for a lot of the variation in gene expression. I guess there's just so much individual variation. I guess PCA probably isn't appropriate with such a small number of samples relative...

The 13 differentially expressed genes are between the SARS+F+ group and the SARS+F- group. That's good. Although 20 people is not a big sample.

So SARS+F+: 20 participants SARS-CoV-2 positive; high fatigue (numerical CFQ>=21); meeting WHO PCC and Fukuda criteria SARS+F-: 20 participants SARS-CoV-2 positive; low fatigue (numerical CFQ<=11); not meeting WHO PCC and Fukuda criteria SARS-F+: 20 participants SARS-CoV-2 negative; high fatigue...

:rofl: for the cat, and :rofl: for the fact that the abstract is three paragraphs long, but only addresses the title in the very last sentence. And that sentence looks as though it was nearly forgotten, an 'oh, and...'

I do wonder about the informed consent - did participants really understand that the results would be used to try to label their fatigue as a product of attentional and interpretational biases? I laughed about the comment about the welfare of animals. Because humans are animals and the authors...

Onto interpretation bias: The problematic information processing biases are taken as a given in ME/CFS, with the aim being to compare and contrast. Implicit Interpretation bias task To summarise, for each of 12 ambiguous scenarios, participants had to rate how similar 4 sentences were...

that can't be viewed outside the UK - what's the gist?

That's a sad story. The following paper says there isn't one particular part of the brain that causes neurogenic stuttering and even a small lesion can disrupt the neural network producing fluent speech. That suggests to me that neurogenic stuttering might easily be mis-diagnosed as an FND...

Ah, thanks @Andy, I had missed it. I'll merge them.

Thanks for posting the article. I've been working through blood pressure issues for and with my Dad. He's been tried on a few new medications to lower his blood pressure in addition to one he is already one, and they all came with significant side effects. A couple caused dizziness and...

Good to have you here JoClaire I think it is really hard to prove that ME/CFS isn't an FND while there is no diagnostic biomarker. Even then, then there are examples of people with clearly physical ailments being diagnosed with a functional overlay, either because their physical diagnosis...