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That looks to me more like mounting evidence of poor quality research. There are figures in those papers that simply do not add up as far as I can see. The Swedish study suggests that nearly half of people with autism have the very rare disorder EDS (1/5000)* If they do not have this rare...

The review brings together some useful background clinical and epidemiological information. The section on pathogenesis is pedestrian and I think unrealistic, but it is the received dogma it seems. An interesting point is that they quote ms as a potential model for autoimmunity due to...

If nerve cells have got nadgered by viruses there ought at least to be a few NK and T cells around. And if they are chucking out RNA related to leucocyte activation that is only 'aha' if there is some leucocyte activation to my mind. I have no idea what you find in various causes of anosmia but...

1. Take n people who have been told they have FND and n people who have not 2. Note that 'FND' is shorthand for YBAIYDIEIYSII (you're barmy and it's you doing it even if you say it isn't.) 3. Look for activity in brain regions expected in people who have been told they have YBAIYDIEIYSII 4...

It is another peculiar journalistic piece from BMJ. The author sounds as if they are gritting their teeth and being almost even-handed about presenting the politics because they have no alternative. The Colleges seem to have wimped out. Javid has changed the dynamics.

I cannot see any biomarker here. They report some correlations within groups but say nothing about differences between groups in the abstract.

Don't let a lack of understanding of basic physiology lead to harm for the people with #LongCovid, #MECFSand other chronic conditions that are under your care That is exactly right yet Putrino seems keen to treat people before he has worked out the physiology. Step one is to be critical of...

Which looks just as bogus as the deconditioning theory.

Yes, but do we have any reason to think they are a good thing. As far as I can see unless you understand the reason for the hypocapnia this is as unjustified as Chinese herbal remedies.

And that is my worry. People not familiar with physiology will happily follow these treatments. The principle remains that unless you actually know what is going on you have to assume that your treatment is just as likely to make people permanently worse as permanently better.

What evidence do we have for that? We don't know what triggers any individual case. I am not sure what you mean by that. I am talking about a probabilistic analysis of how confident one might be that an environmental event was relevant. I think an important point to make here is that there...

This sounds like gobbledygook to me. If these RNAs indicate a relevant injury process we should see some injury on conventional old fashioned histology - at least a few leucocytes infiltrating maybe? I am also doubtful of the relevance of mechanical hypersensitivity. At one time it was said to...

I thought Garner had seen the light, according to his own blog, following talking to psychotherapist friend in the USA. Maybe they put him on to Norway but that could have been epiphenomenal.

I think there are two different questions here. One is what is a plausible lag period for an environmentally triggered condition. The other is what lag period for an individual is likely to be more than coincidence. Most diseases triggered by environmental agents (assuming brief exposure)...

The blind leading the blind maybe?

Putrino's general approach is certainly sympathetic. I think we need to know more about the physiology before starting treatments though. If there is a lowish CO2 that might be a useful compensatory response so not something to try to reverse.

No doubt BPS enthusiasts have made a living out of PWME. My point was more that this has nothing much to do with the CDC having a 'policy of disregard for ME'. Ms Johnson is missing the point. In recent years the failing of the CDC has been to look at the evidence properly and make appropriate...

Absolutely, but there seems little point in searching for an unknown mystery virus that might have caused one or other outbreak of an illness that may have led to some cases of ME fifty years ago.

Planck's Equation E = hv That is to say that low energy=low frequency, high energy =high frequency, so there's no such thing as: Low energy, high frequency It's garbage.

Maybe they need this in Bristol since, if I remember rightly, students at Bristol are the most miserable in the country. Didn't we used to have this treatment for sleep irregularity sixty years ago? 'Time you were in bed and stopped playing that guitar.' I was taught that sleep problems were...