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    Comedians could be prescribed on NHS to help patients struggling with trauma: Bristol Uni

    At least the thread title made me smile. :)
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    Poll: Does taking supplements to 'support' mitochondria at a particular time of day improve your sleep?

    Your poll should have allowed multiple selections for 'didn't improve' or just had one selection for 'didn't improve regardless of when taken'. None of the supplements listed affected my sleep. What has had a positive effect is CLAs (conjugated linoleic acids). Without them, I generally wake...
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    Brainstem Abnormalities in [ME/CFS]: A Scoping Review and Evaluation of Magnetic Resonance Imaging Findings, 2021, Nelson et al

    I hope there's some good followup research on this.
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    Medscape: Fast Five Quiz: Chronic Fatigue Syndrome (Myalgic Encephalomyelitis)

    Well, I scored zero. :facepalm: It's all guessing what the 'experts' guess is correct, since they don't actually know for sure.
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    No signs of neuroinflammation in women with [CFS] or Q fever fatigue syndrome using the TSPO ligand [11C]-PK11195, 2021, Raijmakers, Knoop et al

    It may not be as simple as standard neuroinflammation, but I'm still convinced that it's part of my ME. My ME symptoms always increased with infections or exertions that would produce IFN-g, which would in turn activate glial cells. So far there's no definitive study (large, proper controls...
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    ME/CFS progression in years and stages

    21 years, constantly mild with varying degrees of feeling a bit better or worse. I've had quite a few symptoms and sensitivities occur and change or disappear. I managed to cure my PEM, persistent neuropathic muscle aches, and another problem that required treating with T2, and an intolerance...
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    Male vs. Female Differences in Responding to Oxygen–Ozone Autohemotherapy (O2-O3-AHT) in Patients with ME/CFS, 2021, Chirumbolo et al

    Did they compare this to any other pain reduction techniques? Maybe females are simply more likely to check 'improved' rather than 'no change' on these sorts of questionnaires.
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    Article: How to Tell if Sitting in Front of a Computer All Day Is Making You Fatigued

    Aside from the psycho-nonsense issue, different brain activities have different effects on overall feeling. Playing a strategy game past 2:30 PM gives me insomnia that night, but playing a first-person shooter game (mindless shooting of zombies) doesn't. Maybe some neurons deplete something or...
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    Can Understanding Gut-Brain Axis Biopsychosocial Pathways Improve Clinical Reasoning?, 2021, Ford et al

    The amazing thing: there's probably someone out there who is actually proud of creating this nonsense. :rolleyes: Oh, and if it doesn't result in a major accolade for transforming patient care, it will of course be the fault of the nurses for not implementing it properly, or the patients for...
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    What differentiates ME/CFS from known primary mitochondrial diseases; could mitochondrial disease cause PEM?

    It could be, but it could also be just a malfunction that evolution hasn't weeded out yet. If your computer stops working because a single transistor ot trace failed, it isn't because it's trying to protect itself from further damage.
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    What differentiates ME/CFS from known primary mitochondrial diseases; could mitochondrial disease cause PEM?

    Died from being left behind because "You look fine, you're just being lazy." :(
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    Open Pilot Study: A Novel Transcranial Magnetic Stimulation Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

    Maybe they saw that by a few minor changes in their procedures, they could qualify for ME research funding. That's likely to happen with other research projects: put out the sweet smell of money, and pesky bugs come around to feed... :mad:
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    A Short Corticosteroid Course Reduces Symptoms and Immunological Alterations Underlying Long-COVID, 2021, Utrero-Rico et al

    I wonder whether long covid has the same 'treatments often work great the first few times, then stop working and never work again' syndrome.
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    Do meals affect heart rate and symptoms inpostural orthostatic tachycardia syndrome? 2021, Kate M Bourne et al

    I posted a link to a new finding on Phoenix Rising regarding another possible mechanism for ME affecting heart rate. They found glial cells in the heart, which are part of heart rate control. I believe that ME affects glial cells, so that could affect heart rate. Eating could alter immune...
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    Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2021, Simonato et al

    I'm convinced that ME is neurological, so I don't expect serum studies to reveal much other than some downstream effects.
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    Insular cortex neurons encode and retrieve specific immune responses, 2021, Tamar Koren et al.

    This offers another possibility for chronic inflammation: those neurons might be maintaining the active state after the trigger has been removed. If you add in ME altering neural function, it could be locking us into a feedback loop, with the inflammation altering the neurons in a way that...
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    Acceptance and Commitment Therapy for ME/CFS - Discussion thread

    Is there any way we can convince psychologists to come up with ways to fix their own problems? They shouldn't give (bad) advice to other people until they fix their limited perspectives and poor experimentation procedures. :grumpy:
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    The micro-clot finding in Long Covid — implications for the possible aetiology of ME/CFS

    I'm unconvinced that this hypothesis fits with the rapid switching between full ME symptoms and full temporary remission. This switch of state takes place over a scale of minutes rather than hours. I triggered remissions via three different chemicals: prednisone, cumin, and T2. I don't see...
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    Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue..., 2023, Guo,Lipkin et al

    I think if it was an effective treatment for ME, someone would have noticed it after taking butyrate supplements. I've had different antibiotics and drastic diet changes, which should have affected my butyrate production, but I didn't notice any significant differences in my ME.
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    Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients, 2023, Xiong

    I came across this news item just after reading this thread, and it seems to fit it: https://newatlas.com/health-wellbeing/microbiome-gut-bacteria-inflammation-colitis-pgp/ "But more recently P-gp has been found to also play a key anti-inflammatory role in the gut, producing molecules known as...
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