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If that's not enough, they can call it 'quantum resonant biopsychosocial dysregulation' plus any other scientifically-sounding words that are popular with marketers. :rolleyes:

My ME problems with TRP seem to be in excess conversion to neurotoxic kynurenines in the brain. BCAAs can block, or at least delay and spread out the increase in symptom severity, so I'm pretty sure it's not a digestive system problem. Hopefully there won't be too many people with this...

I had to look up "central sensitisation". It looks like some scientific terms mushed together in a way that sounds impressive, but doesn't actually mean anything, or rather, that it can be used to explain nearly anything without providing any useful techniques for dealing with it. I don't...

I've encountered several treatments that worked well the first few times I tried them, then they stopped working and never worked again. That's just part of ME. I haven't come across any official hypotheses for this effect, but I assume that ME sets some factor in our cells that our bodies...

The title was so absurd that I had to check the thread. :)

"These dysregulated microglia are hyperreactive to signals from the peripheral immune system, producing an exaggerated and prolonged central cytokine response to an otherwise mild immune challenge. The primed microglia then become resistant to normal regulation, failing to revert to the...

If you define green light as a certain narrow part of the spectrum, then yes, but you'll get more in direct sunlight. If you want to define 'green light' for medical therapy as magnitude in that part of the spectrum and nearly no magnitude in the rest of the spectrum, then no, forest shade...

Melatonin can help me fall asleep, although it's not all that reliable. However, if I take it after 2AM, it leaves me feeling severely groggy the next day, worse than not sleeping at all. 5-HTP also worked, but I can't recall whether it had the same grogginess effect. Tryptophan might have...

I did suffer from neuropathic pain, but I treated that quite well with LDN, and after a year or so, I no longer had that pain. I still may develop it when my other ME symptoms are severe, but it passes on its own.

With any of the sleep meds, I'd worry about dependency.

I'm convinced that problems in the cerebral kynurenine system are a significant part of my ME, so this paper provides another possible explanation for how.

Yes, but my post was just making a humorous connection to Mithriel's avatar. Poor bear. Surely finding your teddy all poked up would cause ME. ;)

I'm definitely an outlier. Others have reported ME with no loss of physical performance, but I also was very effectively treated by cumin and T2, which haven't worked for anyone else. I think that outliers have the potential to reveal otherwise hidden aspects of ME, but as you say, we could...

Adverse childhood events? As in "You developed ME because you found your teddy bear stuck full of needles when you were 3 yrs old?" ;)

That's an important part of science: establishing the reliability of new measurement techniques. Without it, a study of ME brains with this technique is just colourful pictures.

It makes perfect sense to me. You used muscles beyond their normal limits, which triggered your immune system to clean up the damaged cells, and the resultant cytokines caused your symptoms, directly or indirectly.

I suffered malaise after exertion, so that's within the definition. It doesn't say post exertional endurance loss. That didn't seem to be part of my PEM either. I felt much worse when the PEM kicked in, but I didn't notice any reduction in endurance. I expect that my legs would have managed...

Actually, I'm a poor choice for explaining the differences, because my PEM was non-standard in some ways and I never had crashes. I've simply read lots of other people report a wide variety of responses that get labelled "PEM", which I didn't experience myself. For me, PEM was simply a...

Maybe if they subdivided the groups based on astrological signs, or first letters of their names (or their pet's names), or some other such random divisions, they'd eventually find an even stronger statistical correlation. :rolleyes:

"Our research goal is to make some random numbers appear to say something we want them to say." :rolleyes: