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Proline is used in so many reactions in the body that it's more surprising that more people don't develop sensitivities to it, or any other individual amino acid. My guess is that there's some reactions in some cells that are proportional to local proline levels, which in turn affect my ME...

By lots of experiments with foods of differing ratios of amino acids. Wheat, for example, is unusually high in proline. Foods that had a high ratio of another amino acid compared to proline didn't bother me, which allowed me to eliminate some candidates. As an extra check, I tried consuming...

A bit over a year ago, I got what I am pretty sure was a flu virus. As typical for me, I had mild flu-like symptoms for a day or two, then it passed. However, sometime after that I became very sensitive to proline (amino acid) and my ME symptoms were significantly worse after that. I recently...

They're doing detailed statistical analysis on the subject' vague and varying judgements about their 'energy and fatigue levels'? Garbage in, garbage out. :rolleyes: Might as well publish the mathematical results from 1-5 ratings to 1000 decimal places. :rolleyes::rolleyes::rolleyes:

I'm guessing that the researcher hasn't had significant contact with patients with severe symptoms. If so, her paper should have a disclaimer regarding the severity of the patients in her study. I've just recovered from a year of worse ME possibly due to some form of long-covid. I was...

The problem with those 'helpful strategies' is that PWME have such varied responses to treatments (or strategies) that it's unlikely to help many people. They'd basically need one research project for each individual. Hmm, I'm not sure just how much benefit there'd be for developing dietary or...

I'd take the hypothesis more seriously if LDN was more widely reported as an effective treatment for ME symptoms. For me it was wonderful for blocking my neurologically-perceived aches, but it did nothing else for my other ME symptoms. It doesn't matter how nice the hypothesis sounds, or how...

I see TCM and other such practices as based on a theoretical base of complete nonsense (four humours, magical energies) modified by thousands of years of experience of what works and what doesn't. Since the theories are meaningless, they could be modified to fit actual observations. So, the...

My PEM seemed to be just increased severity of my general ME symptoms. I didn't get any new symptoms, or any on your list above. I expect that PEM involves a common core dysfunction, but how that expresses itself downstream depends on the individual. I agree; it varies with the individual...

Hormones, which are created by or controlled by the brain? Feedback control of the muscles? Erroneous signalling to the muscles (fighting each other rather than working efficiently)? Incorrect control of breathing and bloodflow to accompany muscular action? There's so much feedback between...

They do communicate with each other, and both respond to cytokines. They evolved to work together, so if one is disturbed, the other will probably be too. The other glial cells have similar interactions.

It doesn't show whether it's a cause or an effect. ME-affected bodies are abnormal, so there's no reason why it can't result in less ability to remove various toxins.

I think you're on the wrong pathway. I never experienced that sort of 'energy limitation'. My physically-induced PEM was triggered by what I believe was muscle microtears (caused by using muscles in ways other than usual daily activities), not by general exertion*time. My cognitively-induced...

The abstract certainly doesn't entice me into reading the full article. It sounds like they didn't find anything new, so they put their efforts into making it look impressive, or at least to intimidate readers into not asking questions.

https://osf.io/ef3n4/ The newsbrief posting reminded me that this paper wasn't mentioned. I think it may be a pretty important hypothesis for ME's root cause. It fits what I believe is the root cause of ME: that neuroglia are involved. I'm not sure whether there are any ME symptoms that...

All those projects, and I only like the one studying brain inflammation.

I haven't noticed any changes in my ME due to weather. I have a Type I allergy to something in the air in winter around evergreen trees when certain conditions are met involving temperature and humidity (and probably other factors). My guess is that something is releasing spores. Your...

How does one factor in the fact that people who get 2 doses have different mindsets than those who get one dose, who have different mindsets than those who haven't gotten vaccinated? Strong belief in the protection of 2 doses is likely to make those people underreport any symptoms.

I had, and still occasionally have, what seems to be neuropathic pains due to my ME. I consider that a symptom of ME that some but not all PWME have. I certainly don't believe that neuropathic pain is the cause of ME. Besides, I don't think they understand central sensitization either, so...

Doctors don't know how to treat FNDs, so these patients are less satisfied with healthcare services than patients with treatable disorders. Makes sense to me. Doctors who are unable to satisfy patients are less satisfied than doctors who are able to satisfy patients. Is anyone else noticing a...