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Ah, but I think the harassment claims were fed to them on purpose. I gather that Leadsome came up with the bit against the defence secretary because he had arranged to have her sacked. It's all a bit like The Death of Stalin.

I had lunch with a couple of enlightened journalists who write health articles for major dailies yesterday. I think the flawed nature of PACE is now recognised at least by those taking a serious interest. Also the mention of SMC produced guffaws of an encouraging kind. They were not aware of...

As far as I know it will. The route will just be a bit different. Any glucose not converted to fat will either be stored temporarily in the liver as glycogen or burnt off. Your hypothalamus will adjust how much is burnt off so that your temperature stays at 36.5. If glycogen hangs around long...

There may be a problem with serum too: (the second plasmin step is not relevant) Nat Med. 1995 Sep;1(9):932-7. Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin. Grainger DJ1, Wakefield L, Bethell HW, Farndale RW, Metcalfe JC. Author information...

No it does not indicate anything about losing weight, because you can only store as fat calories that are excess to what you need to use. As long as you keep the calorie intake down the body will shift the molecules around over 24hrs to give the same result. It does not matter what the post...

Afraid not. It is written as if by someone in the 1960s who is completely unaware of the developments of the 1990s. This problem seems now to be all pervasive. All research is copying what has been read in a review last week. Chinese whispers you might call it.

Fair comment, @Trish, but there is no doubt that, as Valentijn said, there is an implicit aspect of 'girl power' in all this. There certainly was when I was research advisor to our physiotherapists in the 1980s. It became clear that my resistance to vacuous qualitative research was seen as male...

@Inara, I absolutely agree that exercise and thyroid status and all sorts of other things will affect how many calories you need to eat to stay the same weight. But it remains the case that, taking this into account, if you eat more calories than this you will put on weight and if you eat less...

I agree that it is encouraging that new groups are looking at ME. However, the project outline immediately above is disappointing. Firstly, it seems to be an exact repeat (i.e. not 'novel') of what Simon Carding and Tom Wileman have already been doing for five years in Norwich. Secondly, as an...

With respect I think you are missing my point. I think Valentijn's post #36 indicates what I meant. I have lots of girlie scientist friends - of course. Jo Cambridge has a pink spectacle case and a purple hair brush on her desk and loves riding ponies. But you will never find her writing like...

There is no need to assume that people will get worse again after improvement. In young people long term improvement is common. The Dubbo study indicates that there is no precise cut off between people who have post-viral fatigue for six months and then recover and those who have fatigue for...

I seem to remember Simon Wessely saying that people should not raise awareness of mental illness because there was no mental health service to deal with them. So maybe he should not ask questions of trainees that do not exist! (Or perhaps do exist but are so overworked that they will say...

I think it would depend entirely on what the mode of action of the anti-retroviral was and what the mechanism of the target illness was. On the other hand, although anything can produce a placebo response it seems relatively unlikely that an anti-retroviral would be effective for ME if it was...

It might be worth asking a rheumatologist. One possibility is a tenosynovitis of one of the peroneal muscles that runs round the outside.

People clutch at straws and Mikovits's story was told with such conviction that people believed it. But the re-assessment was able to identify a point in the lab where the virus had mutated so it was possible trace back where the problem was almost like having a CCTV recording. Patients with ME...

I think Social Sculpture might be what Marcel Duchamp did and signed 'R Mutt'. Very creative

@erin Which movement hurts most - foot up and down, foot side to side or just standing? I am not supposed to practice rheumatology here but I can make general comments!

Katherine should come and join the fun here. She might need her passport for the pub though.

The retrovirus from Mikovits turned out to be a lab contaminant - clearly shown by the exact sequence of the virus matching a contamination source. It made no real sense, being a mouse virus anyway and there being no epidemiology to fit. This was sorted out around 2013-4 by an international group.

George was once a good friend of mine but he got heavily into quackery. My hope is that whatever review NICE undertake it will at least identify the lack of valid evidence for LP. Even the CBT/GET people will want to ensure that. The worry is that ME/CFS management is widely delegated to OTs who...