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News in Brief posts for w/c 23rd Sept. Twitter: Facebook: https://www.facebook.com/sci4me/posts/pfbid0cZYFjsPq67eUZbMuZMeLUXMKyU2WeFa1zuioR8qf8PMGaUcWVsHibmMFF1xp9vA8l Bluesky: https://bsky.app/profile/scienceforme.bsky.social/post/3l5buil7rs22b Mastodon...

To manage expectations, "a result" might be anything between evidence for no genetic influence all the way through to clear evidence for the genetic basis of ME/CFS and targets for drugs. Better phrasing might have been "once the analysis of the genetic data is complete then the results of the...

Abstract Subacute combined degeneration of the spine (SCDS) is a well-known disease that classically presents with progressive sensory and motor deficits and characteristic magnetic resonance imaging (MRI) findings, leading to its use as a key diagnostic tool. However, clinical and MRI findings...

From the link above, "ME and long Covid Numbers for people with long Covid fluctuate. Research by Davis et al (2023) identified that around 50% of people with long Covid have symptoms that directly mirror ME (including the key-defining feature of ME, post-exertional malaise). Using figures...

Abstract The present commentary raises some concerns about the risk of iatrogenic harm arising out of the diagnosis of functional neurologic and somatic disorders. These concerns are supported by evidence from the history of hysteria and findings from contemporary brain imaging. We discuss...

Published papers thread for w/c 16th Sept. Twitter: Facebook: https://www.facebook.com/sci4me/posts/pfbid0Z5iUqTXWk4ZFbBePaMQxP1bJtQjuPFSqom9dRLSW6iMBHbyGAxfHFSMCizvbMFUPl Bluesky: https://bsky.app/profile/scienceforme.bsky.social/post/3l4sqv5eexm2h Mastodon...

Not surprising, "Research summary Laura McWhirter's research interests are in cognitive disorders, functional neurological disorders, and brain injury. Current research interests Dr McWhirter's current primary research project aims to describe various clinical phenotypes in Long COVID. Past...

For what it is worth, existing discussion threads on; What research do you want to see? (study ideas) Research priorities for ...(ME/CFS): the results of a James Lind alliance priority setting exercise, 2022, Tyson et al

News in Brief posts for w/c 16th Sept. Twitter: Facebook: https://www.facebook.com/sci4me/posts/pfbid0MfMch3RJLmwZbj1hjbwzh2UKNjDBM5F5Atox8fw2cWWyhc1Z4svWLEihwLt5Kq6hl Bluesky: https://bsky.app/profile/scienceforme.bsky.social/post/3l4qj3c566r2m Mastodon...

Abstract ‘Brain fog’ is a term that patients use increasingly frequently in the neurology clinic. We may think that we know what patients are talking about but at least some of the time we are likely to be getting it wrong. Patients use the term ‘brain fog’ to describe a wide range of...

Not sure how active it is, if it still exists, but it was discussed here, Nurses for ME

Hypermobility spectrum disorders (HSD) and hypermobile Ehlers–Danlos syndrome (hEDS) are the most common joint hypermobility conditions encountered by physicians, with hypermobile and classical EDS accounting for >90% of all cases. Hypermobility has been detected in up to 30–57% of patients with...

Trial By Error: Norwegian Tabloid Covers Stupid Gulf War Illness/PEM Study; My Letter to Journal Editor on Bogus Claims https://virology.ws/2024/09/20/trial-by-error-norwegian-tabloid-covers-stupid-gulf-war-illness-pem-study-my-letter-to-journal-editor-on-bogus-claims/

The Life Improvement Trial (LIFT) has officially begun! https://www.omf.ngo/lift-update/

Full title: One More Tool in the Tool Belt: A Qualitative Interview Study Investigating Patient and Clinician Opinions on the Integration of Psychometrics Into Routine Testing for Disorders of Gut-Brain Interaction Abstract Introduction Disorders of gut-brain interaction (DGBIs) encompass a...

Tweet from PrecisionLife "We're delighted to share the progress being made in the #MetX research study. PrecisionLife and @MetrodoraInst have begun sharing the first results with #MECFS and #LongCOVID participants - bridging from Biobank Analysis to Bedside in record time...

Trial By Error: UK Health Care Professionals Appeal to Health Secretary for Quick Action on Poor ME Care "Tuesday, September 17th, was World Patient Safety Day. (I didn’t know that either.) In the UK, more than 200 physicians, nurses and other health care providers and professionals marked the...

Abstract Introduction Myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) is a chronic condition which may be characterised by debilitating fatigue, post-exertional malaise, unrefreshing sleep, and cognitive difficulties. ME/CFS has significant negative impact on quality of life for...

Ironic that Chew-Graham has signed it, given her involvement with the FINE trial and her interest in "..anxiety and depression, multiple health conditions, unexplained symptoms..", https://www.keele.ac.uk/medicine/staff/carolynchew-graham/#research-and-scholarship

Highlights • SCFAs activate the NLRP3 inflammasome under inflammatory conditions • SCFAs inhibit HDAC activity, altering the LPS-dependent transcriptome • This causes loss of cFLIP and IL-10 expression, triggering NLRP3 activation • SCFA-mediated NLRP3 activation causes hyperactivation but not...