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Published papers thread for w/c 9th Sept. Twitter: Facebook: https://www.facebook.com/sci4me/posts/pfbid02P8kh6Rc6BHm6LwDUM77GZdoYUBXFxvXfRaiKtEMDMrqV4ButefsqspzpC1vw9Ti3l Bluesky: https://bsky.app/profile/scienceforme.bsky.social/post/3l4azhncb3y2s Mastodon...

"Furthermore, since our previous work, in the context of clinical trial NCT04174300, identified differences in response to MT among FM patients co-diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) [18], we reassessed our RT-qPCR results, taking into account whether or...

Abstract Fibromyalgia (FM), classified by ICD-11 with code MG30.0, is a chronic debilitating disease characterized by widespread pain, fatigue, cognitive impairment, sleep, and intestinal alterations, among others. FM affects a large proportion of the worldwide population, with increased...

News in Brief post for w/c 9th Sept. Twitter: Facebook: https://www.facebook.com/sci4me/posts/pfbid02dHuPXpBJunQfLN1aaWhahQ6G6MBQf2cJM8J2TtBUtP6XARkB8xhTfskfha9jpux2l Bluesky: https://bsky.app/profile/scienceforme.bsky.social/post/3l46mwpjvnv2m Mastodon...

Full title: Correlates and predictors of symptom severity over time in people under investigation for postural orthostatic tachycardia syndrome (POTS) Abstract Objective Postural Orthostatic Tachycardia Syndrome (POTS) is a poorly understood chronic disorder characterised by an unexplained...

So what about other discussion threads about papers where the study authors suggest that their results are, or could be, a biomarker? In order to understand the quality of that other work should we not copy all posts discussing biomarkers in general to all those other threads? If not, why not?

Associations of physical activity levels with fatigue in people with inflammatory rheumatic diseases in the LIFT trial Abstract Objectives The overall aim of the current study was to quantify physical activity levels in inflammatory rheumatic diseases (IRDs) and to explore their role in...

I need no biochemical knowledge to understand from the abstract that; here the authors explain that butyrylcholinesterase is worthy of investigation. It is also something that could be of interest to pwME, which is why the paper came to my attention. and that here they explain that they went...

So as general discussion they are off topic to this thread and were correctly moved as per the forum rules.

I've just scanned through the moved posts and there is nothing in the content of those posts that indicates that they are specific critiques of this paper. I always find discussions about general topics within threads which are about particular papers to be unhelpful; having to read discussion...

The abstract tells you why they selected this particular drug.

Full title: Repurposing Duloxetine as a Potent Butyrylcholinesterase Inhibitor: Potential Cholinergic Enhancing Benefits for Elderly Individuals with Depression and Cognitive Impairment Abstract Despite the advent of new treatment strategies, cholinesterase inhibitors (ChEIs) are still the...

Introduction 1]. MUS are often attributed to functional somatic syndromes like fibromyalgia, chronic widespread pain, chronic fatigue syndrome, temporomandibular disorder, and irritable bowel syndrome, which are all characterized by symptoms without discernible biological or physical causes and...

Full title: Medically unexplained symptoms and experiences with healthcare among emerging adults exposed to multiple types of potentially traumatic events Abstract Experiencing multiple types of traumatic events can increase the risk of developing somatic and posttraumatic stress symptoms...

Published papers thread for w/c 1st September. Twitter: Facebook: https://www.facebook.com/sci4me/posts/pfbid02x544CNfxfZh6eX145TmK6hSazrxNvmfkderJxpuFdC6PTJf2Ns4HHSrR6dp23vDUl Bluesky: https://bsky.app/profile/scienceforme.bsky.social/post/3l3pobqc7ht23 Mastodon...

See Chronic fatigue syndromes: real illnesses that people can recover from, 2023, The Oslo Chronic Fatigue Consortium for further discussion of them.

News in Brief posts for w/c 1st September. Twitter: Facebook: https://www.facebook.com/sci4me/posts/pfbid02HpT35wbJzkSpQ9u7HmDWx9pAKuVnEvsFAeg4bPohLy1av3WJwsEjnrGMb6CMjiscl Bluesky: https://bsky.app/profile/scienceforme.bsky.social/post/3l3n5774nsi2i Mastodon...

Trial By Error: Bogus Claims in Study of Exercise and PEM in Gulf War Illness "A recent study investigated a question no one seems to have been asking. That can be a good thing—if it’s a question that’s worth investigating. But that’s not the case here. The study, published in the journal...

Highlights A nominal association was found between clinical outcome and TPH1 variant. A TPH2 and OXTR gene-gene interaction might modulate symptom severity. TPH1, TPH2 and BDNF gene-gene interaction might modulate clinical outcome. Abstract Objective We studied gene-environment, as well...

Abstract Functional Neurological Disorder (FND) is continuing to gain increasing recognition globally as a valid and potentially treatable disorder. Iatrogenic harm towards patients with FND is significant however, and has been around for centuries. Despite advances in our understanding around...