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Current total is 10,563 https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review

Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous disorder with elusive causes, but most likely because of clinical and other biological factors. As a vital environmental factor, the gut microbiome is increasingly emphasized in various refractory diseases...

News in Brief posts for w/c 26th Feb. Facebook: https://www.facebook.com/sci4me/posts/pfbid0fbFTxw7RqeaBmXUNLxZgn3fHNnMo4FrukZEi1Zi5PEsVRekp8XgBPUPw6c1j33Enl Mastodon: https://med-mastodon.com/@s4me/112031105015752024

Something found as well in the DecodeME cohort, Typing myalgic encephalomyelitis by infection at onset: A DecodeME study, 2023, Bretherick et al

Highlights Patients entered more frequently into insular-somatomotor co-activation. Patients entered less often into insular co-activation with subcortical regions. Dynamic alterations correlated with alpha-amylase and duration of illness. Functional alterations reflect prioritizing...

Solve's response, https://solvecfs.org/solve-responds-to-findings-from-the-nih-intramural-me-cfs-clinical-study-published-in-nature/

February News in Brief thread posted to Reddit https://www.reddit.com/r/cfs/comments/1b3roj8/news_in_brief_posts_for_february_2024_covering/

Abstract Patients with chronic fatigue syndrome (CFS) frequently demonstrate intolerance to physical exertion that is often reported as increased and long-lasting fatigue. Because no specific metabolic alterations have been identified in CFS patients, we hypothesized that sensitized fatigue...

@JohnTheJack asked the question on Twitter. Their reply was "Great question John! The definition our team uses is "bed bound or house bound", but if you want to know more about the criteria you can contact them here: https://cureme.lshtm.ac.uk/contact-us/. Hope that helps."

[In mice] Introduction: Post-infection syndromes are characterised by fatigue, muscle pain, anhedonia, and cognitive impairment; mechanistic studies exploring these syndromes have focussed on pathways downstream of Toll-like receptor (TLR) 4 activation. Here, we investigated the mechanistic...

It didn't, it's replying to an opinion piece from last year.

Thread here, NICE guideline on ME/CFS: robust advice based on a thorough review of the evidence, 2024, Barry et al.

Presumably this is their response to the "Anomalies" opinion piece from this thread, https://www.s4me.info/threads/anomalies-in-the-review-process-and-interpretation-of-the-evidence-in-the-nice-guideline-for-cfs-me-2023-white-et-al.34097/

From that link, "His research protocols focus on deeply phenotyping persons with disorders characterized by aversive symptoms that develop after exposures, such as infection.".

Abstract Background The hypermobile Ehlers–Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are connective tissue disorders characterized by generalized joint hypermobility, associated with chronic pain and several symptoms, such as fatigue, dysautonomia, as well as psychiatric...

Abstract Fibromyalgia patients vary in clinical phenotype and treatment can be challenging. The pathophysiology of fibromyalgia is incompletely understood but appears to involve metabolic changes at rest or in response to stress. We enrolled 54 fibromyalgia patients and 31 healthy controls to...

Trial By Error: An Interview with Neuroscientist Michael VanElzakker about the Just-Published and Long-Awaited NIH Study https://virology.ws/2024/02/28/trial-by-error-an-interview-with-neuroscientist-michael-vanelzakker-about-the-just-published-and-long-awaited-nih-study/

Statement from the Bateman Horne Centre about the study, "But, no study is perfect. In our opinion, this one fell short by not including enough patients who are moderately to severely ill. That happens frequently in ME/CFS research, and was probably amplified by the travel, rigor and duration...

Replication would always be a good thing and is something that we are proactively talking about with researchers who have access to existing datasets - however there isn't a well defined nationwide genetic dataset from the States, so for what it is worth we would support the establishment of one.

I suspect that they use Chronic Fatigue Syndrome but more mean chronic fatigue. "Various assessment tools have been developed to assist in the distinction between fatigue and CFS. One of the most used tools is the Expanded Disability Status Scale (EDSS), developed by Kurtzke for the evaluation...