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Abstract BACKGROUND: Multiple sclerosis (MS) is a chronic, inflammatory demyelinating disease that affects various parts of the central nervous system. Fatigue, a common symptom, transient, prolonged, or chronic experienced by individuals with MS, can significantly impact daily functioning. It...

A reminder that if you haven't completed the second DecodeME questionnaire and have been invited to do so then you only have until the end of this month.

Published papers thread for w/c 19th Feb. Facebook: https://www.facebook.com/sci4me/posts/pfbid0c5tzGT3AfGfDuhSyfECoKQuePpevrFJfoqb7kWWBHMDddAiuUgFVLfaQHEJgfoHbl Mastodon: https://med-mastodon.com/@s4me/111997360250828344

Abstract Mitochondrial respiration extends beyond ATP generation, with the organelle participating in many cellular and physiological processes. Parallel changes in components of the mitochondrial electron transfer system with respiration render it an appropriate hub for coordinating cellular...

"Self-regulation theory is a valuable foundation for self-management, which aims to equip patients with the tools they need to effectively cope with an ongoing condition or the aftermath of a healthcare event (Taylor et al., 2014). We therefore sought to provide a ‘scaffold’ for people with...

Abstract Purpose Fatigue is a common and debilitating problem in patients recovering from critical illness. To address a lack of evidence-based interventions for people with fatigue after critical illness, we co-produced a self-management intervention based on self-regulation theory. This...

"Exercise-based management of individuals with hypermobile variants of EDS and related disorders (i.e., CFS, and fibromyalgia) needs to be cognizant of the impact of pain, fatigue, post-exertional malaise (PEM), and broader dysautonomia affecting gastrointestinal (e.g., functional motility...

Full title: The use and effectiveness of exercise for managing postural orthostatic tachycardia syndrome in young adults with joint hypermobility and related conditions: A scoping review Highlights Little research on exercise for POTS management in joint hypermobility conditions...

News in Brief posts for w/c 19th Feb. Facebook: https://www.facebook.com/sci4me/posts/pfbid0tyQFmhybXc5nXEU33VPVrJUuL2USL554DJiamZVauGpZgSiVzwHdXsLaegpoEqd9l Mastodon: https://med-mastodon.com/@s4me/111991755540340215

Abstract Amidst broad changes to the somatic disorder diagnoses, DSM-IV pain disorder was absorbed into DSM-5’s somatic symptom disorder (SSD) as a specifier. However, clinical research testing of its use for the chronic pain population has been limited and its utility remains inconclusive...

Abstract Background Fatigue is a debilitating symptom of myasthenia gravis (MG). The impact of fatigue on MG can be assessed by Quality of Life in Neurological Disorders (Neuro-QoL) Short Form Fatigue scale. Transformation of raw Neuro-QoL fatigue scores to T-scores is a known approach for...

Abstract Autoimmune autonomic ganglionopathy (AAG) is a disease of autonomic failure caused by ganglionic acetylcholine receptor (gAChR) autoantibodies. Although the detection of autoantibodies is important for distinguishing the disease from other neuropathies that present with autonomic...

Abstract Postural orthostatic tachycardia syndrome (POTS) is a common accompaniment of a variety of chronic, inflammatory diseases, including long COVID, as are small, insoluble, 'fibrinaloid' microclots. We here develop the argument, with accompanying evidence, that fibrinaloid microclots...

As Eleanor points out immediately above, the authors seem confused on this point as well.

Exactly this. Yet, as Snow Leopard has confirmed, both patients and controls received the supervision, so it is as much proof of exertion avoidance in controls as it is in patients.

Great, thanks for pointing that out. The question still remains though of why they should feel the need to imply that encouragement of patients and patients achieving RER of 1.1 demonstrate proof for their effort preference theory.

I think you missed the point that the authors of this paper highlight that they encouraged the patients but not the controls. Encouraging one set of participants and not the other, if that is what has occured, is introducing bias.

Abstract Background Functional neurological disorder (FND) is characterised by neurological symptoms, such as seizures and abnormal movements. Despite its significance to patients, the clinical features of chronic pain in people with FND, and of FND in people with chronic pain, have not been...

The broad question asked here is "Do you think that research should be published with, or without, a preprint stage?". We have recently seen the disappointment of the NIH intramural study, where the authors were determined not to preprint, and so we were unable to get prepublication sight of...

Datasets from this study have been added to the mapMECFS portal, https://www.mapmecfs.org/dataset/?organization=nih-intramural