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The problem with a standardised care plan would be the differences between the severity levels and individual patients - no one plan would cover the range of possibilities.

Moderation note: The overwhelming response from members has been that this document is not fit for purpose. If people are considering using the template or recommending it to others, we suggest first reading member comments in this thread. Update 5th September. AfME has withdrawn the document...

Highlights GWAS across four cohorts reveals eight loci for Raynaud’s syndrome ADRA2A shows temperature-dependent smooth muscle contraction Endothelial nitric oxide modulates the susceptibility to Raynaud’s syndrome ADRA2A, NOS3, and ACVR2A can be targeted by existing pharmaceuticals Summary...

Now at 11,288 signatures. https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review

Perhaps @PhysiosforME could help achieve this, given the subject matter?

Posting mostly because the corresponding author is our 'mate' Michael Sharpe.

Summary Background Older people admitted to hospital in an emergency often have prolonged inpatient stays that worsen their outcomes, increase health-care costs, and reduce bed availability. Growing evidence suggests that the biopsychosocial complexity of their problems, which include cognitive...

"CONFLICT OF INTEREST STATEMENT Sara E. Williams and Nicole E. Zahka are authors of the text “Treating Somatic Symptoms in Children and Adolescents” and receive relayed royalties, though did not participate in the intervention delivery, data collection or analysis, or results of the study."

Abstract Objective Cognitive Behavioral Therapy (CBT) for youth with Disorders of Gut-Brain Interaction (DGBIs) is effective; however, there are calls in the field to strengthen the evidence base and identify specific mechanisms of treatment that yield the most benefit for this patient...

Trial By Error: A Deeper Dive into the Inquest’s “Findings and Conclusions” "In fact, the testimony revealed a complete lack of understanding of ME among almost all the health care providers, whether based at the hospital or in the community. This lack of understanding appeared to lead to some...

Tweet put out Mon at 15:49. "LC/ME hivemind - we need your help! We’re looking for an established scientist who has worked on ME and/or Long Covid to write a piece for #ThereForME. We want to know how you would spend £100m annual biomedical funding over 5 years. Would need a draft by COB [close...

Abstract Objective To report the prevalence and severity of nonpelvic symptoms for patients with venous-origin chronic pelvic pain (VO-CPP) and to describe outcomes after pelvic vein stenting and embolization. Methods We retrospectively reviewed outcomes of 45 women with VO-CPP who underwent...

Now on YouTube.

If elevated levels of WASF3 had a genetic basis and it was present in sufficient numbers of participants in DecodeME, then yes, it is possible that DecodeME would find it. Perhaps, but it would very much depend on the results. It might be that elevated WASF3 might be due to some other disrupted...

"Increased expression of WASF3 in transgenic mice markedly decreased their treadmill running capacity with concomitantly impaired respiratory supercomplex assembly and reduced complex IV levels in skeletal muscle mitochondria." WASF3 disrupts mitochondrial respiration and may mediate exercise...

Abstract Background Despite their high prevalence and burden, disorders of gut-brain interaction (DGBI) are undertaught and underrepresented in medical curricula. We evaluated the exposure of UK gastroenterology trainees to DGBI and their comfort managing these conditions. Methods An...

Posting in case of interest to those who are able to access it.

Abstract Background GI-specific psychological factors are important contributors to patients' symptom experience and quality of life across all disorders of gut-brain interaction (DGBI). Clinicians' ability to recognize the role of these psychological factors is essential for formulating a...

A non-ME/CFS case of gastroparesis. Woman with paralysed stomach told she was anorexic "A woman lived with a paralysed stomach for three years and was told she might die after doctors wrongly diagnosed her with anorexia. Luned Davies, 23, has gastroparesis which affects the nerves in her...

Abstract Background Fatigue is a common complication of stroke that has a significant impact on quality of life. The biological mechanisms that underly post-stroke fatigue are currently unclear, however, reactivation of latent viruses and their impact on systemic immune function have been...