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Objective: Medically unexplained symptoms (MUS), such as chronic fatigue syndrome, irritable bowel syndrome, and Gulf War Illness (GWI), are difficult to treat. Concordance—shared understanding between patient and provider about illness causes, course, and treatment—is an essential component of...

A thought inspired by the currently ongoing UK consultation on ME/CFS - has anybody compared the research funded by the UK funding bodies since 2013 and assessed in the NICE guideline process to see the quality of evidence provided by those studies? My immediate assumption is no. In the...

Latest funded project. Investigating spinal nerve cell function and the serotonin system in ME/CFS Researcher Prof. Janet Taylor Institution Edith Cowan University, Australia https://www.meresearch.org.uk/research/taylor-064/

I wonder how the authors believe they themselves are resistant to "Pandemic-Response Syndrome", especially as in writing this piece of absurd fiction scientific paper they have exposed themselves to far more concepts of and writings about Long Covid than the average member of the public would...

Abstract This review proposes a model of Long-COVID where the constellation of symptoms are in fact genuinely experienced persistent physical symptoms that are usually functional in nature and therefore potentially reversible, that is, Long-COVID is a somatic symptom disorder. First, we...

From the discussion. "According to our data, at the 2-week follow-up, almost half of the children (N = 10, 47.6%) experienced exercise intolerance with secondary-induced tiredness after any physical activity. Additionally, three children (14.3%) could not walk for more than 15 min or climb the...

"Two weeks outcome All children were examined 2 weeks after the MIS-c diagnosis was established. The patients were hemodynamically stable during the evaluation and showed significant clinical improvement after receiving immunomodulatory therapy. However, the most persistent complaint was...

Background: Multisystem inflammatory syndrome in children (MIS-c) emerged during the coronavirus disease 2019 pandemic and is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite the extensively studied clinical manifestation of acute condition, the short- and...

Functional neurological disorder (FND) may mimic various kinds of neurologic diseases and may coexist with other neurologic disorders. In cases overlapped by FND, it might be challenging to distinguish symptoms induced by FND and those induced by other underlying neurological disorders...

Reddit thread for the August News in Brief. Copy and paste https://www.reddit.com/r/cfs/comments/1671l27/news_in_brief_posts_for_august_2023_covering/

Dendritic cells (DCs) have a role in the development and activation of self-reactive pathogenic T cells1,2. Genetic variants that are associated with the function of DCs have been linked to autoimmune disorders3,4, and DCs are therefore attractive therapeutic targets for such diseases. However...

Highlights CD4+ T cell-intrinsic arginase 1 controls Th1 induction and contraction kinetics Loss of arginase 1 in CD4+ T cells results in reduced Th1-mediated tissue pathology Th1-intrinsic arginase 1 ensures balanced glutamine vs. arginine metabolism CD4+ T cell-intrinsic arginase 1 and 2 have...

Lactate is a glycolysis product that is produced from pyruvate by LDH (lactate dehydrogenase) and plays an important role in physiological and pathological processes. However, whether lactate regulates autophagy is still unknown. We recently reported that LDHA is phosphorylated at serine 196 by...

I did need to boost the volume a bit in order to him clearly, it was OK for me but it might be challenging for others with more sensitive hearing than me.

David Tuller: Interview about DecodeME with Professor Chris Ponting "Professor Chris Ponting is a geneticist at the University of Edinburgh. He is also the principal investigator for DecodeME, a genome wide association study. The DecodeME team recently published findings from more than 17,000...

From an email from IACFSME. 2023 IACFS/ME Conference: Video Recordings Now Available for Purchase! The cost of one pass to the online video recordings is $300 USD for Non-Members and $250 USD for IACFS/ME Members. Your purchase includes: a. Unlimited, online access to all presentations...

As Patient and Public Involvement (PPI) in research becomes more widely accepted, and expected, by funders, there already is a growing need for PPI members with lived experience of ME/CFS, Long Covid and other related conditions. This thread is intended as a space where requests for PPI members...

I assume, but could not see confirmation, that this now supersedes this review, Cochrane Review: Psychological therapies for the management of chronic pain (excluding headache) in adults, 2020, C De C Williams et al.

Background Chronic pain (pain lasting three months or more) is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Common types (excluding headache) include back pain, fibromyalgia, and neuropathic pain. Access to traditional face‐to‐face therapies...

Preprint. Now published - see post #18 This is from Maureen Hanson's group. Abstract In healthy individuals, physical exercise improves cardiovascular health and muscle strength, alleviates fatigue, and reduces risk of chronic diseases. Although exercise is suggested as a lifestyle...