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Merged NIH Director's blog: Brain signatures for chronic pain identified in a small group of individuals "For the first time, researchers have recorded pain-related data from inside the brain of individuals with chronic pain disorders caused by stroke or amputation (phantom limb pain). A long...

Full title: Parasympathetic autonomic dysfunction is more often evidenced than sympathetic autonomic dysfunction in fluctuating and polymorphic symptoms of "long-COVID" patients Abstract Several disabling symptoms potentially related to dysautonomia have been reported in “long-COVID” patients...

Chronic viral hepatitis is a systemic disease characterized by a wide range of extrahepatic manifestations, such as cognitive impairment, chronic fatigue, sleep disorders, depression, anxiety and a decrease in quality of life. This article presents a summary of the main theories and hypotheses...

Nope, not that I could find. However, "All patients fulfilled the CFS criteria and 261 had typical ME (72%), 101 (28%) had atypical ME."; I understand that to mean that 261 (72%) met the ICC and that the balance has atypical ME, which is just those who only met Fukuda, which they describe as...

The incidence of type 1 diabetes in children increased during the COVID-19 pandemic,1-4 but studies have not discriminated between children with and without infection. We analyzed a large population-based, individual-patient data set that included diagnoses of COVID-19 to determine whether there...

"During the first visit, we determined by history taking of the treating physician whether patients satisfied the criteria for CFS (Fukuda et al., 1994) and ME (Carruthers et al., 2011), taking the exclusion criteria into account. " "All patients fulfilled the CFS criteria and 261 had typical...

Trial By Error: Questions About the Prevalence of Functional Neurological Disorder and the Research on Hoover’s Sign for Functional Leg Weakness "I have great sympathy for patients diagnosed with functional neurological disorder (FND). Their symptoms can be seriously disabling and their plight...

"We are asking people to complete a short survey about their health experiences and the support they have received from the NHS and social care services. This anonymous survey will help us to: Improve NHS and social care services Raise much-needed awareness Better understand how people's...

Highlights Clinical manifestations of the long COVID syndrome include cognitive impairments, named “brain fog”. Previous literature suggest possible mechanisms that might result in altered cortical excitability. This study confirms impaired glutamate and GABAb regulatory pathways in long...

Background Dyspnea and fatigue are characteristics of long SARS-CoV-2 (COVID)-19. Cardiopulmonary exercise testing (CPET) can be used to better evaluate such patients. Research question How significantly and by what mechanisms is exercise capacity impaired in patients with long COVID who are...

Published papers thread for w/c 15th May Facebook: https://www.facebook.com/sci4me/posts/pfbid0yw1kn762TbigbCjdus6PyTBw2nJFGdJq656exLvBTSJVcgcU9dCXJx8re7Q1jG1gl Mastodon: https://med-mastodon.com/@s4me/110411378487276799

Section snippets Case Report A 59-year-old woman, Mrs. A, was referred for an outpatient telemedicine psychotherapy consultation in the department of neurology at a large academic medical center. Five years earlier, she had begun experiencing neurological symptoms including gait and balance...

Now published Increased Levels of Inflammatory and Endothelial Biomarkers in Blood of Long COVID Patients Point to Thrombotic Endothelialitis The prevailing hypotheses for the persistent symptoms of Long COVID have been narrowed down to immune dysregulation and autoantibodies, widespread organ...

News in Brief posts for w/c 15th May Facebook: https://www.facebook.com/sci4me/posts/pfbid02Fnzv69LPCoT44HgumvDSxFf1As9vqMNDbPz5F24aeBYXv7GmcAZDAJvoHc5bsrZxl Mastodon: https://med-mastodon.com/@s4me/110405693381471634

Full title: A systematic literature review on the clinical efficacy of low dose naltrexone and its effect on putative pathophysiological mechanisms among patients diagnosed with fibromyalgia. Highlights There is only low grade evidence to support that LDN reduces pain and improves quality of...

Background Successful management for functional neurological disorder (FND) requires multidisciplinary involvement starting with providing a definitive diagnosis. Objectives To observe clinical management of patients with FND during hospital admission. Methods A prospective observational study...

"criteria for CFS" = Fukuda

Background: Limited published data suggests that absence of uplifts (minor pleasant events) is associated with clinical worsening in patients with chronic fatigue syndrome (CFS). The current study aimed to assess the relation of illness worsening to the trajectories of social and non-social...

"This report analyses survey responses from ten NHS Health Boards in Scotland to understand delivery of ME/CFS services, implementation of the updated ME/CFS NICE guidelines, barriers and opportunities to implementing the guidelines, and options for future ME/CFS service development."...

The funding notice. Digital Health: Innovative engineering technologies to improve the understanding and management of fatigue Fatigue is considered as a "final common pathway": a vague clinical symptom that can result from many different diseases and mechanisms. Our limited understanding of...