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Yes had a similar experience. I think there is some research in terms of MS that suggests that vitamin D (or the lack of it) effects the strength of the blood brain barrier. I'm not sure we should take a paper looking for associations between the CFQ and anything seriously. Its too poor a...

Kate E Earl, Giorgos K Sakellariou, Melanie Sinclair, Manuel Fenech, Fiona Croden, Daniel J Owens, Jonathan Tang, Alastair Miller, Clare Lawton, Louise Dye, Graeme L Close, William D Fraser, Anne McArdle, Michael B J Beadsworth Abstract Objective Severe vitamin D deficiency is a recognised...

I think it is interesting that they do because it makes a clean cohort where the issues won't be suspected to come from other causes.

From the bits of the paper I read they were careful to to over claim. We can talk about correlation and causation and here I think it is important to understand the findings in the context of what we know about cell biology and hence what the statistics mean in terms of the mechanisms we...

From the press release So it looks like a before and after exertion study which I think is exactly what we need in terms of ME and understanding the dynamics of the illness. It maybe that tests require this rather than a static snapshot.

There are websites setting out the process but they are confusing, From https://www.myresearchproject.org.uk/help/hlpamendments.aspx#1 The boundaries don't seem clear around converting a feasibility study to a full study. This link also seems relevant...

I don't think I am write and I think they are trying to mislead. The letter I quoted suggesting they had ethical approval for the change: http://www.bristol.ac.uk/media-library/sites/ccah/documents/Ethics%20-%20Amendment%202%20-%2020%20August%202012%20-%20Reply.pdf Is from the hospitals R&D...

This is one I've never come across before. My first thought was it doesn't make sense for chronic illness. I guess the paper you pointed to sounds like it didn't find anything of interest but I've only scanned the abstract. I can see that people who have had and recovered from acute illnesses...

I'm assuming this is an independent replication of the two day exercise testing.

Amendment 2.0 seems to have been reviewed by the R&D committee which I assume is the full thing? It includes So it looks like the ethics committee did approve the conversion to a full study. But I still think that seems dodgy. In that I would question whether they gave it their full attention...

From this letter http://www.bristol.ac.uk/media-library/sites/ccah/documents/Ethics%20-%20REC%20Review%20of%20SMILE%20Project%20Letter.pdf I thought that he was promoting the fact the trial was being done by the NHS.

I notice that they have not included information about the two amendments just the letters saying they were accepted. The two lines refer to the same document which appears to be a convenient mistake. So as far as I can tell by scanning through the documents they have not said what the...

I tend to think that here we are not really a market for academic papers. They are too expensive. But we have an interest in the research and reading it. The real issue for the journals if they loose the personal subscriptions and library subscriptions that bring in the big money. I can...

I wouldn't be surprised if she got angry letters from parents of her patients (I was tempted but didn't - I did tell a social worker as a passing comment that I thought she represented a danger to children by pushing GET and activity based therapy). But given the child protection issues are...

She is not actually a psychiatrist her first papers were on things like leukemia, IL-10 in RA/Lupus. Which I think means she should know better and should understand her methodology is poor. But I like the idea of someone giving a presentation as an edgy beat poem. Or perhaps as a more modern...

I thought there was evidence around certain anti-depressants being good for chronic pain. But I guess this is looking at just depression. I thought there were some suggestions that anti-depressants may work better for pain than depression. Something to do with slowing/blocking signals in the brain.

I couldn't find the CDI questions but it does seem to be tested on a small group Wiki says: https://en.wikipedia.org/wiki/Children's_Depression_Inventory The comment on diabetic children suggests that as a scale it is not robust to co-morbid conditions. Given the issues with questionnaires...

In my world there are malware analysts who ask lots of unconventional questions and quite a few seem to have strange backgrounds and not necessarily degrees etc. Security is another thing where there is a mentality to do it well.

I think critical thinking and doing well at school can be very different. I do think there is a mentality for a researcher which is to question everything and want to understand. But people who do well at school and university don't need that mentality - it can even hold people back.

I've done that