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... and will continue to do so until they move from cost and subjective outcomes to effective objective outcomes. Cost can be a secondary measure only, and really only a factor in evaluating what to try first. To be fair a lot of EBM is still doing the right thing, and uses objective outcomes...

I don't think EBM was a mistake, but its a human endeavour, and has been infiltrated by people pushing their own agenda. EBM also took a wrong turn with EB Management. When the primary outcome measure is cost, saving money, then its inevitable it moves in the wrong direction. Nearly the whole...

Sigh. Don't they ever read the literature on ME exercise physiology? An entire branch of research is routinely ignored.

This is old news now. In mice they can make them young again. They can also accelerate ageing. The drugs used in the best experiments, including by Sinclair, are at risk of triggering cancer. Cells become undifferentiated, they need to figure out how to dedifferentiate cells only enough, but...

Yes, things are going to change a lot about this story as we get more and better science.

This is quite plausible. Many countries will have limited testing and public health infrastructure. Many cases might be missed over much of the world. Its also likely infections started much earlier, and it spread much further, we just have not done the testing.

More and more data is coming out of the USA that shows the virus has been spreading much longer, many more were infected, but the death rate is much lower than previously thought. The first death in US was in California (Santa Clara) on Feb 6, but when you take into account incubation and...

My state of Queensland, Australia will be relaxing some distancing rules in just under a week, allowing non-essential shopping and some other activities. This follows only three cases in our state in the last day or so, and zero a few days ago. We also have the launch of a mobile phone app which...

Yes but I think the point is the capacity to make such deliveries is rising, the opportunities rising, as aspects of society gear up for an increased delivery of services. Its the downside now that might lead to an upside later. The question is how much of this capacity will be retained after...

Pure speculation, but it looks to me as though its orchestrated, part of an evolutionary response, perhaps in respect to viruses. It hasn't necessarily kicked in all the way with milder patients, but does so when a patient goes severe. There are two questions here ... first, what is the...

I have yet to read the study, but based on what is earlier on this thread this study is not claiming no mitochondrial dysfunction. Its claiming severity is not associated with mitochondrial dysfunction. This means that the sicker patients have more or less the same mitochondrial function as the...

Apparently, from internet doctors, severe lung infection requiring a ventilator can take up to a year to recover from. We need to look for symptoms other than fatigue or being out of breath to indicate ME if any exist.

I hope this is not a reporting glitch, but good news in Australia. After plateauing for most of a week, new cases plummeted yesterday to a level not seen since the start of the pandemic. I do think it will spike suddenly for a bit, as we are taking in maybe 100 cases from cruise ships - I am...

The thing about immunity is its not about circulating antibodies, those just indicate that there was an immune response. Its about how fast the adaptive immune system can activate upon subsequent infection. Circulating antibody levels are possibly indicative but not reliable.

I don't think it has been established as over active immune responses, but it is less clear about antiviral responses. In fact there is data showing underactive immune response. Some things are elevated in the research, like low molecular weight RNaseL. There seems to be a differential response...

Very likely. Even serious medical issues are being ignored by many right now, with people turning up late into their heart attacks and strokes.

That is my very strong suspicion also ... bordering on certainty.

I heard of a case where they still tested positive for the virus some 37 days after "recovery". This does not mean they were infectious, nor is this necessarily right, but it is something that scientists need to look at.

Few antibodies to the first infection imply less immunity than expected to subsequent infections. Not good. This might also impact vaccine effectiveness. I hope this research is not completely right.

The secondary consequences are potentially very, very bad. So many without insurance is also bad. I am very worried for my American friends for many reasons right now. PS I think its been discussed that the already high cost of having medical insurance is about to be massively increased, some...