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Does Murphy have a good understanding of ME? According to a person diagnosed with mito disease and not involved in any way with the ME community those with mito disease can have something resembling PEM. Maybe PEM will just end up being part of a regulatory response that is seen when there is...

I came to a similar conclusion, which was: the illness he is experiencing or went through may have been a time where he felt awful and hopeless, a time for reflection and reevaluating his life, and also remembering other events from the past that were similar. I suspect he does not have a good...

The author says on Twitter that Atg13 in serum is “result” of autophagy impairment, not the “cause”. Autophagy was initially discovered by studying starvation, then later it was also found to play a major role in homeostasis. Autophagy sounds like the kind of maintenance process that might be...

I would like to invite Hungarian patients and professionals from relevant fields to join the global movement that aims to make lives better for ME/CFS patients and their families. We want to better understand what this illness is, develop diagnostic tests and find effective treatments.

The effect of cool water immersion is clear enough for me that I don't need instruments. I'm however not certain that what changes is the ANS. Within seconds, something in the body calms down, breathing and heart seem to go slower, deeper, stronger and it just feels right.

It helps degrade catecholamines, including dopamine, adrenaline and noradrenaline. The variant rs4818 of the COMT gene is very common in the general population so one would not expect it to have a large effect.

I think an important aspect of PEM is a strange inability to function well. I have what I would consider "mild PEM" at the moment. I tried to do some undemanding software work and I'm having difficulty completing any of the tasks I set out to do. I run out of patience and get frustrated, make...

I'm not sure. Maybe they're just naive and are being misled by the BPS spin. It's strange how the BPS research gets funded so easily with so little quality control.

I take carnitine which seems similar to this drug as it also acts on PPAR and improves utilization of fats for energy production. Carnitine lets me do more and for longer.

A Study to Evaluate ASP0367 in Participants With Reduced Maximum Oxygen Uptake Due to Poor Systemic Oxygen Extraction The purpose of this study is to to evaluate the effect of ASP0367 on improvement of aerobic capacity relative to placebo, as well as evaluate the safety and tolerability of...

I found that comment a bit worrying. The authors might be thinking that they just need to find the right type and dose of exercise.

Who knows. There is no way to show that a person has a repressed emotion or does not have a repressed emotion. By definition if it's repressed then it's not observable. And the method claimed to bring repressed emotions to the surface, ("recovered memory therapy") is now considered a method of...

Excuse me, a radical new understanding? Repressed emotions as cause of disease is what Freud claimed 120 years ago.

CBT imperialism.

Genetic testing can be performed with a device called SNP chip. Not all genetic testing is done with these. Direct-to-consumer genetic testing companies like 23andME often use SNP chips. A problem with SNP chips is that they are unreliable when it comes to rare gene variants. There is the risk...

It's definitely important to know about the problems and limitations with genetic testing. However: The article says that direct-to-consumer genetic testing often uses a method called SNP-chip, which can falsely report the presence of a rare and therefore likely pathogenic variant. This is...

That's an amazing discount and a much more reasonable price for something with uncertain benefit for many patients. I bought it.

Besides labelling glucose a placebo in context of sport, this is also a n=1 story where something very ordinary happens (one cyclist performs better than another) that is then interpreted as supporting conclusions that don't really follow from the observation (the cyclist performed better...

That is quite possibly not a placebo.

I heard about a CBT therapist once who ruined her marriage with compulsive shopping behaviour that she couldn't stop. Isn't that the kind of problem CBT is meant to fix?