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  1. Hutan

    "Gastrointestinal symptoms, diet and health-related quality of life in ME/CFS" 17-minute recording of Breanna Weigel presentation

    Yes, this does seem to be a well recognised thing. I recall cases particularly around Sydney, people develop an intolerance to meat due to tick bites. https://www.abc.net.au/news/2019-01-18/how-ticks-can-cause-mammalian-meat-allergy/10719136
  2. Hutan

    The Qigong of Prolong Life With Nine Turn Method Relieve Fatigue, Sleep, Anxiety and Depression in Patients With CFS:, 2022, Xie et al

    That's pretty intensive CBT. Primary outcome - MFI-20 - fatigue Secondary outcomes - Overall efficacy evaluation - probably as good as any subjective measure - 4 levels - basically complete cure, nearly a cure, a significant improvement, and minimal or no change, also incorporating the MFI-20...
  3. Hutan

    The Qigong of Prolong Life With Nine Turn Method Relieve Fatigue, Sleep, Anxiety and Depression in Patients With CFS:, 2022, Xie et al

    Th recognition that GET and CBT might not be effective treatments is good, although I'm not sure where the schizophrenia fits in. That's Friedberg F. ME/CFS: Primer for clinical practitioners. (2014). Available online at: www.iacfsme.org. (accessed July 2014). That primer should be withdrawn...
  4. Hutan

    Metabolomic Evidence for Peroxisomal Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2022, Levine,Hornig,Lipkin et al

    This is for the whole ME/CFS sample versus all the controls. This sort of sounds good, but it's quite a bit of fiddling with the data. For example, I wonder how much race/ethnicity or even geography actually influenced metabolite levels, and if the adjustment process might have happened to...
  5. Hutan

    Metabolomic Evidence for Peroxisomal Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2022, Levine,Hornig,Lipkin et al

    The build up of those two compounds is consistent with the itaconate shunt hypothesis, because the itaconate stops the breakdown of succinate (and I think alpha-ketoglutarate is upstream of succinate). Itaconate shunt hypothesis video—Robert Phair
  6. Hutan

    Metabolomic Evidence for Peroxisomal Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2022, Levine,Hornig,Lipkin et al

    https://bscb.org/learning-resources/softcell-e-learning/peroxisome/ Acetyl-CoA is of course a neurotransmitter and is important in the TCA cycle. It possibly makes sense that if the cell goes into low energy mode, reducing energy production in the TCA cycle so that pathogens can't use the...
  7. Hutan

    Metabolomic Evidence for Peroxisomal Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2022, Levine,Hornig,Lipkin et al

    Some background: https://med-life.ca/plasmalogens Peroxisomes are organelles in the cell (the pink blobs). They make plasmalogens and acetyl-CoA and other things, and break down excess long chain fatty acids, uric acids and other things that might be a problem if they aren't broken down...
  8. Hutan

    Nature: A preoptic neuronal population controls fever and appetite during sickness, 2022, Osterhout et al

    There's a lot of speculation and a number of things that are just plain wrong in that table in the Morris and Maes paper.
  9. Hutan

    Could the kynurenine pathway be the key missing piece of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) complex puzzle?, 2022, Kavyani

    I've just got around to reading some of the paper. The abstract is a fair indication - it's a real mess of misinformation throughout. One of the authors, Gilles Guillemin was promoting the paper on Linked In as great team work, and I have to wonder, has he even read it? What for example has...
  10. Hutan

    Human enteroviral infection in fibromyalgia: a case-control blinded study, 2022, Armin Schwarzbach et al

    I don't think the results tell us very much about whether enterovirus infection is not associated with fibromyalgia either. All it really tells us is that simply having an infection is not in itself enough to cause fibromyalgia. Lots have people have had polio virus, not everyone becomes...
  11. Hutan

    International: IACFS/ME - International Association for CFS/ME, IACFSME

    A reminder on this - please get in touch if you are interested in helping to report on the presentations.
  12. Hutan

    Examining Long-Term Health Effects of COVID-19 and Implications for the Social Security Administration: Proceedings of a Workshop, 2022

    There's good stuff: Recognition of similarity to ME/CFS, even if it's not made explicit, and mention of PEM: Recognition of the need for training - although there's inconsistent talk of Long Covid as a diagnosable entity while at the same time using it to mean anything from post-ICU issues...
  13. Hutan

    The Pharmaceutical Journal: Chronic fatigue: it is time to take its treatment more seriously - by Christine Parry

    That's a dispiriting article all round. There's Julia Newton who has contributed as much to the confusion between chronic fatigue and ME/CFS as anyone talking about new horizons: Perhaps if she had done her 2011 study properly and not suggested ME/CFS could be fixed with more physical...
  14. Hutan

    When It Hurts, a Positive Attitude May Help. The Moderating Effect of Positive Affect ... in Women with Fibromyalgia, 2022, Ecjia et al

    I'm really tempted to create a tag called "patronising tosh" and use it to categorise this study.
  15. Hutan

    Lightning Process - discussion thread

    Again Parker uses that effect of the images bouncing bigger and smaller while his soporific voice suggests that everything will be alright if we just pay him lots of money. He must imagine that it is some sort of hypnosis.
  16. Hutan

    Ethical considerations related to post-infection syndromes in epidemics

    Do you have any links to where this is documented Peter?* So perhaps my second point above needs to have a wider scope and consider what safety nets are in place for people with ME/CFS and whether they are treated equitably compared to people with other equally disabling conditions. And...
  17. Hutan

    Ethical considerations related to post-infection syndromes in epidemics

    If the prospective studies we have (Dubbo, Jason's mononucleosis study) are any guide, odds are in favour of recovery at the 4 month mark when NICE's diagnostic criteria allows diagnosis, and at 6 months when some other criteria allow diagnosis. I think it is right to generally be positive...
  18. Hutan

    United Kingdom: UKCRC (UK Clinical Research Collaboration) Subgroup on ME (part of the UK Government ME/CFS Delivery Plan)

    We have an existing thread on the Hospital Passport idea in Advocacy here - Members Only M.E. hospital and health passport, plus members experiences of hospital stays and visits.
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