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What can they deliver e.g. if they've delivered the limited benefit they can then why not try something different? Simon Ponting's GWAS study offers an opportunity to understand the underlying genetic basis for ME. Given that these other approaches don't seem to return people to a normal life...

Never looked carefully at PACE but your comments seem to apply to it --- poor quality research used as the basis for Government policy. Seems that, on the Government policy side, there is no-one with sufficient understanding to say this is crap --- so yes there is a risk that this could be used...

Yea fair point - I was thinking of adding --- if it were not serious (which it is)!

Thanks for the laugh ---

Hope I'm not saying the wrong thing here but "listening to and analyzing nearly 20 hours of recorded conversations with ME/CFS patients" and "honest and personal conversations that took place with the 43 patients in our study" --- seems a pretty thin evidence base. Holy s--t they published in...

Yea I recall this - no mention of waiting 3 weeks though --- Coronavirus: WHO special envoy tells countries to act quickly www.cnbc.com › 2020/03/31 › coronavirus-who-special-envoy-tells-co... 'Act quickly, act decisively, act robustly' to stop coronavirus outbreaks, WHO special envoy says...

You'd need to check the data security laws; also typically there are emergency powers i.e. to do what is necessary ---- sometimes proposed barriers are just convenient excuses for sitting on your ---

Well, the numbers seem to support what the Australian Government is doing, rather than Florida.

Yea what we really need is insight like: 90% get coronavirus through close contact (via droplets in the air) i.e. in enclosed spaces and not wearing a mask ---- 1% get it through contact with a surface on which the virus has survived 24 hours + All fictitious of course, but I'm not sure...

I'm sure you guys heard about this on the news as well --- virus can survive 28 days on certain surfaces--- The effect of temperature on persistence of SARS‑CoV‑2 on common surfaces...

Yes even a GWAS study @Simon M would be a meaningful way to try to understand the underlying reason why these people are still unwell - possibly even a control group for the Chris Ponting ME GWAS [DecodeME] study. I agree, unlikely that a bit of CBT and GET is going to help get these people...

Yea if it caught us all by surprise then how come the German Government had set up a network of laboratories to diagnose cases i.e. in advance of this pandemic? Answer is other countries had put systems in place after bird flue, SARS 1 ---.

Great reply @strategist I was inclined to respond WT-/WTH when I read the material you quoted --- like the comments from some dude on mind altering substances (never got to parties like that myself) --- good for a laugh though!

I assume someone has pointed this out before i.e. the driver, promoting CBT, is that it is a relativelt cheap intervention and Governments like that! The alternatives cost more and Governments try to reduce taxes i.e. to get elected --- forget efficacy this is about getting elected!

I've no idea whether there is a trap or not. However, Chris Armstrong found low levels of amino acids in blood (low because they were used for cellular energy production?) and glucose was elevated (because it wasn't been used as the "normal" preferred energy source?). Fluge and Mella refined...

Oops apologies you referred to deranged T-cell rather than B-cells - https://www.s4me.info/threads/me-cfs-funding-worsens-as-nih-maintains-status-quo.12949/page-2#post-228586 Thank you very much for the posts - even if I misunderstand them.

Not sure what I'm going to say here. If someone with severe ME was assessed by a psychiatrist, I wonder if Schizophrenia would be a potential diagnosis? I'd like to see more biomedical research on psychiatric diseases like Schizophrenia e.g. GWAS studies - people with ME, and people with...

I'm pretty sure you guys are way ahead of me here. Kynurenine came up following Robert Phairs work on IDO2 i.e. blockage in the conversion of tryptophan to kynurenine owing to IDO2 not working(?). Anyway Robert's work ran into difficulties, measuring the level of intracellular tryptophan wasn't...

One thing @Jonathan Edwards has been highlighting is that rituximab does not kill all (antibody producing) B-cells i.e. it does not kill long lived (antibody producing) B-cells. Another thing that Jonathan has highlighted is that symptoms similar to ME would be produced if B-cells, responsible...

Tryptophan is interesting as this is already the focus of research - kynurinine pathway: 1DO2 Robert Phair (metabolic trap) and Jonas Bergquist is looking at kynurinine metabolism. oxidative stress - Shungua, a member of Maureen Hanson's group, is running a study on the use of N-Acetylcysteine...