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    Research priorities for ...(ME/CFS): the results of a James Lind alliance priority setting exercise, 2022, Tyson et al

    No, that's not necessary. Some of us, such as myself, had reliable PEM that gave reliable symptoms but didn't cause lengthy crashes. A 40 km bike ride (hilly terrain) would reliably trigger PEM 24 hrs later, which would last a day or so. Surely I'm not the only one who had such reliable PEM...
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    A Novel Approach to New Types of Novel Novelty

    Any system that offers benefits is going to have people trying to manipulate it for their advantage. The decision makers need to be aware of the latest methods of manipulation. Personally, I think schools should have mandatory classes in manipulation techniques and how to notice when they're...
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    Research priorities for ...(ME/CFS): the results of a James Lind alliance priority setting exercise, 2022, Tyson et al

    The shape is all vague and wobbly, because it's likely a set of downstream symptoms that varies with genetics, epigenetics, and various other factors. Those factors affect our individual responses to various other factors too. My priority for PEM would be to find some people with reliable...
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    Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and mitochondria: A review, 2022, Pandey (M.Sc. Thesis)

    Their graphic is just vague speculation. How does that "start to paint a clearer picture"? Until they can find a clear difference in mitochondrial function in all PWME, it's still just a wild guess as to what the mechanism of ME is. Mitochondrial function is probably involved, but cause or...
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    Mechanism of the Huangguoshu waterfall forest environment’s promotive effect on human health in Guizhou, China, 2022, Zhu et al

    Nope, you'd be lacking the "unique mixture of negative oxygen ions in this environment". That's an excellent excuse for why this technique--which is so amazingly effective (wild guess, since i haven't read it) in their study--doesn't work for anyone out of the study. ;) I just spent an hour...
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    Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course, 2022, iMSMS Cons

    Which also means that changes occur in response to disease. Now they need to figure out which changes are causes, and which are effects.
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    Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis, 2022, Das et al

    Oh, which mechanisms are those? They list some symptoms, but not any cellular mechanisms. My guess is that they don't have a good grasp of ME, they're just trolling for newsworthy numbers. Another guess: they were hoping to find something amazingly different, such as 80% of PWME having an SNP...
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    Concentrated transdiagnostic and cross-disciplinary group treatment for patients with depression and with anxiety: a pilot study, 2022, Kvale et al

    If Tide said that their new detergent was quantum-resonant-enhanced for greater whiteness, I'm sure they could make up some numbers to prove that it works.
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    Short-chain fatty acids are key mediators of the favorable effects of the Mediterranean diet on intestinal barrier integrity, 2022, Seethaler et al

    Is the Mediterranean diet high-fibre? I never thought it qualified for that. AFAIK, it's the fibre that feeds/supports the bacteria that produce the SCFAs. Hmmm, isn't SCFA production mostly in the colon, while intestinal permeability problems generally occur further upstream? My...
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    YourgutPlus+ - a pro- and pre-biotic supplement

    Alas, I became sensitive to fibre metabolites (I believe it's the propionic acid, but it could be the butyric) a couple of months ago. After decades of above average fibre intake (with no problems from it), even small amounts will make me extremely groggy and sluggish the following day, and it...
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    The utter stupidity of questionnaires as tools for diagnosis. A lighthearted look at some questionnaires misused in ME/CFS research

    I expect on some of those questionnaires, if you answered 99 questions 'no' and one that was vague enough to be considered 'yes', the psychiatrist would say: "Aha! You are definitely depressed. Here's your prescription. Problem solved." I suppose a lot of questionnaires are just...
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    New 'cure' for LC, ME etc? Daily Mail article on 'Microcurrent therapy' - Arc4health

    Darn, I thought the wound healing application had been verified, and I thought I'd read about it in a credible source. Maybe someone will start rating the journals on their percentage of published papers that actually get verified by one or more other groups.
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    New 'cure' for LC, ME etc? Daily Mail article on 'Microcurrent therapy' - Arc4health

    Well, they're nearly identical in that they involve scientific-sounding concepts that are mysterious to most people, and thus easy to make magical claims for. "Magical" electricity and magnet treatments have been around for hundreds of years ... with no proven success, so reskinned versions...
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    PEM discussion thread - post-exertional malaise

    I have an alternative hypothesis: that it's not the overall effort of the activity, but the microtears that occur when using your muscles in ways that you don't usually do, which in turn activates the immune system. I could ride my bike for hours without triggering PEM, but climbing a ladder...
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    PEM discussion thread - post-exertional malaise

    It depends on the type of cognitive effort. Back when I still got PEM, socializing and driving were the most noticeable triggers, and the PEM from driving increased with the driving conditions (icy roads at night were horrible). Number-handling didn't seem to be a problem nor did strategy...
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    PEM discussion thread - post-exertional malaise

    Posts moved from this thread One thing about my ME is that I never noticed any reduction in my physical ability. I didn't do any fancy tests with fancy lab equipment, but my ability to dig large volumes of soil, or handsaw firewood, or ride a bike up steep hills, didn't seem to change. Other...
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    Tiredness, fatigue and exhaustion: all the same or manifestations of a continuum?—Food for thought, 2022, Matti et al

    This triggers a question: do any other languages have better words to differentiate between these similar but unrelated symptoms? Does, for example, Chinese writing have different logograms for fatigued, tired, and exhausted? Hmmm, is there one for brainfog? On I suppose a related note, I...
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    Provide feedback to Google re NHS ME/CFS info

    While checking for something else, I noticed that Google's 'list of common questions' showed this: Does Graded exercise therapy work for CFS? A recent Cochrane review of graded exercise therapy (GET) for chronic fatigue syndrome (CFS) concluded that GET is effective and safe (Larun et al...
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