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If I got stabbed in the butt, I'd run fast too. :woot:

No, that's a terrible name for this disease, because it's possible to have the other symptoms without having PEM. PEM is one symptom, not the core dysfunction. I dislike the term 'CFS' because of its history as a psychosomatic disorder. I try to avoid using 'ME/CFS' because of the 'CFS' part...

So are Olympic rowers going to have IV stands on their sculls? ;)

How likely is it that the testing will lead to a useful treatment or warn you of a serious potential problem that you could avoid? I vaguely recall reading of a few cases where such testing has led to a treatment for some rare disease, or warned of something avoidable, but how many 'worthwhile'...

Yes, but a lot of those non-memorable bits may add up and trigger someone's breakthrough.

The tools and knowledge base from covid research will probably help ME research. If some covid group gets funding to develop a non-invasive tool for measuring blood flow in brain capillaries, that can also be applied to ME research. A database of glial cell properties in covid patients plus...

I think it's likely that they'll find that the aberrant eye movements will vary with the individual. One PWME will have trouble focusing, while another will have trouble tracking, and another will have convergence problems. I think ME varies in which parts of the brain it affects to which degree.

A laptop could use a usb speaker system too. I don't use my computers when lying down, but I expect it would be reasonably simple to arrange a keyboard+mousepad for use. The monitor can be arranged in some way, such as the product Forbin showed. If you can find a way to arrange the...

It's a matter of correlation. I tried a wide variety of foods, and my symptom increase correlated only with proline. I didn't bother to do a detailed statistical analysis using 1000 unrelated foods or anything like that, but the principle is valid. From my experiments, I'm confident that...

Proline is used in so many reactions in the body that it's more surprising that more people don't develop sensitivities to it, or any other individual amino acid. My guess is that there's some reactions in some cells that are proportional to local proline levels, which in turn affect my ME...

By lots of experiments with foods of differing ratios of amino acids. Wheat, for example, is unusually high in proline. Foods that had a high ratio of another amino acid compared to proline didn't bother me, which allowed me to eliminate some candidates. As an extra check, I tried consuming...

A bit over a year ago, I got what I am pretty sure was a flu virus. As typical for me, I had mild flu-like symptoms for a day or two, then it passed. However, sometime after that I became very sensitive to proline (amino acid) and my ME symptoms were significantly worse after that. I recently...

They're doing detailed statistical analysis on the subject' vague and varying judgements about their 'energy and fatigue levels'? Garbage in, garbage out. :rolleyes: Might as well publish the mathematical results from 1-5 ratings to 1000 decimal places. :rolleyes::rolleyes::rolleyes:

I'm guessing that the researcher hasn't had significant contact with patients with severe symptoms. If so, her paper should have a disclaimer regarding the severity of the patients in her study. I've just recovered from a year of worse ME possibly due to some form of long-covid. I was...

The problem with those 'helpful strategies' is that PWME have such varied responses to treatments (or strategies) that it's unlikely to help many people. They'd basically need one research project for each individual. Hmm, I'm not sure just how much benefit there'd be for developing dietary or...

I'd take the hypothesis more seriously if LDN was more widely reported as an effective treatment for ME symptoms. For me it was wonderful for blocking my neurologically-perceived aches, but it did nothing else for my other ME symptoms. It doesn't matter how nice the hypothesis sounds, or how...

I see TCM and other such practices as based on a theoretical base of complete nonsense (four humours, magical energies) modified by thousands of years of experience of what works and what doesn't. Since the theories are meaningless, they could be modified to fit actual observations. So, the...

My PEM seemed to be just increased severity of my general ME symptoms. I didn't get any new symptoms, or any on your list above. I expect that PEM involves a common core dysfunction, but how that expresses itself downstream depends on the individual. I agree; it varies with the individual...

Hormones, which are created by or controlled by the brain? Feedback control of the muscles? Erroneous signalling to the muscles (fighting each other rather than working efficiently)? Incorrect control of breathing and bloodflow to accompany muscular action? There's so much feedback between...

They do communicate with each other, and both respond to cytokines. They evolved to work together, so if one is disturbed, the other will probably be too. The other glial cells have similar interactions.