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I cannot make head nor tail of this. It is time these physiologists explained things more clearly and stopped using impenetrable jargon. I strongly suspect that you cannot deduce much from NIR spectroscopy because so many parameters may shift - much as others have suggested.

Humility is the key - and something drummed into me by my physician father but not something I always saw in colleagues to be sure. But I don't think this study is the answer. The reason you do not ask patients for accounts of the symptoms they think are important is largely that those symptoms...

A smorgasbord of excellent questions, @EndME. In fact that is pretty much exactly as we thought when I left off fifteen years ago and almost nothing has changed other than the appearance of CAR-T now. For RA we identified four crucial positive cycles, one of which was dependent on random...

My mother ate a lot of bananas and is now 102.

That study is underwhelming. They found some shifts in gene expression in circulating monocyte including it seems more CD16 (the main marker of 'non-classical' state). This sort of 'activation' of monocytes in the absence of something straightforward such as raised CRP or ESR is pretty hard to...

It is interesting to see this people getting themselves tied in knots about terminology. If psychological and biological cannot be distinguished then presumably there is no point in talking about a biopsychosocial model or publishing, as Wyller has, in 'Biopsychosocial Medicine'. He is being...

Maybe because nobody could work out what it means? I tried to understand it but it is couched in so much jargon that I could not work out even what they were measuring. They seem to have found increased 'distribution volume' in some places but less in another with p values that look marginal...

I can see it now - the Post Exercise-Pill Post-Exertion-Reminiscent Malaise In Non-exerTers trial.

I might do and I might not. Maybe I can feel it in my bones.

Do people think that this is a useful categorisation 'Energy-Limiting Conditions'? It is not something I am aware of medical professionals talking about. The net seems to be cast very wide - including about 7% of the population. Is it helpful in terms of educating authorities about the nature...

Lupus is under three or four medical specialities. It gets a relatively high level of research funding because medics find it interesting. Lupus research is done all over, without a lupus institute. My work on rheumatoid wasn't in a special rheumatoid institute. I had a small group and we made...

This behaviour goes back to the mid 1980s soon after the internal market was set up. People who take on these jobs know exactly what they are doing and how cynical they are being -getting extra Brownie points, an A merit award and all that goes with it. By 2010 people were jockeying to get into...

Just to be clear, there is a very real choice for potential medical directors - not to apply for a job that cannot be ethically performed, or to resign when that becomes the case. I have seen that choice deliberately not being taken too many times. Doctors have perfectly good salaries without...

Yes, I realised that after writing it quickly and decided not to edit since as you say later, the real problem is elsewhere. I guess I should have said that the medical director should have made sure that he had negotiated sufficient commissioning with the purchaser to ensure that a safe...

I can only quote one case report. I looked after a patient who had developed lactic acidosis from phenformin (a diabetes drug). She became comatose and had to be ventilated. Her lactic acid levels (everywhere) were higher than my senior colleagues had ever seen. We infused her with bottles of...

If only it was so easy! Why not set up an institute for writing Schubert's greatest piano sonata (the one he didn't write cos he died). All you need is robust funding, infrastructural resources... Yeah. What if John Cage is put in charge?

The following posts have been moved from another thread But the 2 day CPET is not an objective measure of PEM. PEM is a symptom that is either there or not. If you have PEM and a normal second day CPET you still have PEM. The second day CPET does not demonstrate PEM. Its value is in possibly...

And of course Paul Garner is supposed to be an international expert on why one should behave differently, but he doesn't.

A fair question but I think there are lots of possible answers. Moreover, the timing of PEM does not fit with a build up of metabolites because it goes on too long despite rest. Take the simple example of using a are to clear leaves from a drive. Five minutes of raking produces no ill effects...

'Velvety skin' is such a subjective thing you can diagnose it in almost anyone. People with true EDS with skin changes have visibly abnormal patches of redundant skin or scars. But those who have skin changes are not hEDS, they are genuine monogenic EDS cases and probably mostly have...