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Not that I am aware of? Diabetes produces generalised neuropathic changes so gastroparesis would not be surprising. We have no evidence of neuropathic changes in ME as far as I am aware.

Jessica Eccles has been suggesting Long Covid patients are bendy too: https://www.theguardian.com/society/2024/mar/19/people-with-hypermobility-may-be-more-prone-to-long-covid-study-suggests Usual Guardian gossip.

Ig protein levels vary a lot within normals and Vh gene usage has never turned out to tell us very much except perhaps for Vh4-34 which is anomalous. I suspect noise.

So what is 'best clinical evidence'? Are there good quality trials? The recent review article abstracts tend to suggest nobody has got very far either in terms of mechanism or treatment evidence. The only consistent documentation seems to relate to diabetes and whatever is wrong there may be...

But in ME/CFS patients, pieces of the virus or bacteria may linger in the body and continue to stimulate the immune system long after the infection should have resolved. Except that they didn't find that and it's a theory older than the hills. Apparently it is also good news that the problem is...

I had a look to see what had been published on gastroparesis and ME/CFS and on gastroparesis in general. My findings: Papers on gastroparesis and ME/CFS = 0. Papers on gastroparesis indicate a recognised problem in diabetes (unsurprising) after surgery and with certain infections although these...

I don't understand why there is no stratification to valacyclovir without celecoxib and vice versa. Any positive result can be ascribed to just taking celecoxib (controls not even being allowed to use another NSAID).

My understanding is that we have no firm evidence for regional paraesthesia being associated with ME. There are lots of potential causes. Sorting them out requires detailed neurological examination and imaging. Even with investigation a clear explanation is not always found. However, if symptoms...

Patients are desperate and patients need treatment. And we can't just wait to figure out the entire pathophysiology, like we need to start. I understand where Brian Vastag is coming from but it isn't so much that we haven't figured out the entire pathophysiology. It is that we still have no...

I don't think jam and sponge indiscretions over a few days will have any long term impact, however barmy they may be at the time. The NHS, as we all know, is falling apart and it does not surprise me that there is no sensible dietetic management but the important thing is to have a regular diet...

This group of diseases has by and large received little attention or funding in decades past — save for long Covid, which is relatively well-heeled at the moment through the RECOVER trial. Other conditions, including chronic Lyme, mast cell activation syndrome, Ehlers-Danlos syndrome, POTS, and...

Thinking about this: I think I could argue that the time when we can interpret fMRI in terms of efforts, desires, agency or whatever will have come when the technology is good enough to provide legally robust reliable lie detectors. As far as I know nobody is suggesting that we have that now...

The argument in the conclusion of the 2010 paper looks bogus to me. Sense of agency and voluntariness are different things. If an apple rolls off the table I will involuntarily jump to catch it but am fully aware that it is 'me' jumping. On the other hand when I have vertigo I lose the automatic...

And I'm afraid multiple researchers have messaged me to say they wouldn't go near M.E. because they are simply too scared. That is very alarming Yeah, well, presumably these are researchers who haven't researched ME, because they are afraid of the patients? What sort of researcher or medical...

And it's 50% off this week, it says.

By this logic old age is the biggest pandemic of the lot. Something should be done about it!

And Vogt's problem seemed to be tinnitus if I remember rightly, which somehow morphed into the territory of ME. There is something peculiarly circular about these stories. Symington tells us to forget the biomedical model. Yet she got better because of brand new brain research into pain...

I really doubt it. Work on lung function basically means breathing and our brains are pretty good at making sure we breathe enough. Interestingly that does not seem to apply in acute Covid where hypoxia occurs with few symptoms but there are complex reasons for that. I have had scores of...

I don't think Garner ever claimed he was cured by the Lightning Process. He preferred to spend his money on scuba diving holidays. He seems to have bee cured by a mysterious phone call from a psychiatrist friend in the USA if I remember rightly. Although there was something about contacting some...

It reminds me a bit of Peter White's claim that for MECFS there is little or no placebo effect, while at the same time saying that CBT works through a placebo effect (encouraging people to believe they can get better). Which is a bit sad for the PACE trial since it means that CBT should not...