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  1. Mij

    Game On for Concussion Therapies

    Oxeia is developing a first-in-class synthetic human ghrelin—an endogenous hormone that crosses the blood-brain barrier—therapy to target the hippocampus. By restoring normal energy metabolism and reducing the toxicity caused by reactive oxygen species (which form in low-energy states), it...
  2. Mij

    Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19, 2024, Hanson et al

    I just want to make a comment about iron supplements in general. I was told to take Palafer many years ago and it was too much (300 mg) to take at once since our body only absorbs 10% and the rest has to be filtered out through the liver which makes us feel sick. This was the best iron...
  3. Mij

    Energy metabolism disturbance in migraine: From a mitochondrial point of view, 2023, Yicheng Wang

    Conclusion In the past few years, we have made great progress in understanding the mechanism of energy metabolism in migraine. KCL-induced CSD and nitroglycerin-induced cerebral vasodilation are commonly used migraine models, which can cause disorders of energy metabolism and lead to oxidative...
  4. Mij

    Yale trial could mark 1st step to preventive treatment in Parkinson’s

    Study will test Humira as potentially preventive treatment in Parkinson’s The trial will assess whether an existing treatment for autoimmune disorders can impede the emergence of Parkinson's symptoms. Hafler and his team have discovered the presence of inflammation in the spinal fluid — the...
  5. Mij

    Single dose of LSD provides immediate and lasting relief from anxiety, study says

    https://www.cnn.com/2024/03/07/health/lsd-anxiety-fda-breakthrough-therapy-wellness/index.html No use of psychotherapy Most research with MDMA and psilocybin has relied on the use of trained therapists who meet and establish a rapport with participants before the drug is administered. Those...
  6. Mij

    Single dose of LSD provides immediate and lasting relief from anxiety, study says

    https://www.cnn.com/2020/02/27/health/lsd-overdoses-case-studies-wellness/index.html The 49-year-old woman, known as CB, had contracted Lyme disease in her early 20s, which damaged her feet and ankles and left her in “significant pain.” In September 2015, she took 55 milligrams of what she...
  7. Mij

    Single dose of LSD provides immediate and lasting relief from anxiety, study says

    New results on efficacy at 12 weeks A single dose of MM120 (lysergide d-tartrate) led to a 48 per cent rate of remission from generalized anxiety disorder at 12 weeks following the drug’s administration, according to MindMed. The MM120 drug also significantly improved clinical signs of...
  8. Mij

    Prevalence of orthostatic intolerance in long covid clinic patients and healthy volunteers: A multicenter study, 2024, Cassie Lee, Darren

    Merged thread Prevalence of orthostatic intolerance in long covid clinic patients and healthy volunteers: A multicenter study, 2024, Cassie Lee, Darren Abstract Orthostatic intolerance (OI), including postural orthostatic tachycardia syndrome (PoTS) and orthostatic hypotension (OH), are often...
  9. Mij

    Xbox leader for inclusive gaming opens up about her own hidden disability

    By that time, she had been on a two-decade roller coaster of health conditions that came and went, including a collapsed lung, liver dysfunction, an intestinal disorder and pain so severe she often lay on the floor in tears between meetings. She was diagnosed with fibromyalgia, chronic...
  10. Mij

    Vortioxetine for the treatment of post-COVID-19 condition: a randomized controlled trial, 2023, Roger S McIntyre et al

    Abstract Hitherto no therapeutic has received regulatory approval for the treatment of post-COVID-19 condition (PCC). Cognitive deficits, mood symptoms and significant reduction in health-related quality of life (HRQoL) are highly replicated and debilitating aspects of PCC. We sought to...
  11. Mij

    News from Canada

    Canadian Covid Society launches to address long-term effects, prevent further illness A new non-profit group called the Canadian Covid Society launched today...
  12. Mij

    Functional hypoxia reduces mitochondrial calcium uptake, 2024, Chris Donnelly et al

    Abstract Mitochondrial respiration extends beyond ATP generation, with the organelle participating in many cellular and physiological processes. Parallel changes in components of the mitochondrial electron transfer system with respiration render it an appropriate hub for coordinating cellular...
  13. Mij

    Coagulation profile in hospitalized children with COVID-19: pediatric age dependency and its impact on long COVID development, 2024, Oksana Boyarchuk

    Introduction: Pulmonary endotheliopathy and microvascular immunothrombosis play a key role in acute COVID-19. Moreover, persistent endotheliopathy and heightened coagulability frequently occur in individuals recovering from COVID-19, suggesting the intriguing possibility of their role in the...
  14. Mij

    Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19, 2024, Hanson et al

    Are they checking your ferritin? My sister has low iron levels from Hashimoto. Did you get your thyroid levels tested?
  15. Mij

    Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions, 2023, Yi-Heng Tai et al

    Abstract Inflammation in the central nervous system can impair the function of neuronal mitochondria and contributes to axon degeneration in the common neuroinflammatory disease multiple sclerosis (MS). Here we combine cell-type-specific mitochondrial proteomics with in vivo biosensor imaging to...
  16. Mij

    Metabolomic Evidence for Peroxisomal Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2022, Levine,Hornig,Lipkin et al

    I have a 3 page report re RBC fatty acids, my omega 3 levels were at 3%. All the the others were within normal range. Taking plant based oils didn't work for me based on my results. I take Webber triple Omega 3 fish oils b/c it's IVO My brain function had noticeably improved after...
  17. Mij

    Reddit - Interesting posts on Reddit, including what some doctors say about ME/CFS

    Dr. Keagen's responses on X I find keeping up with the emerging research on long-covid a bit daunting, and I teach it. The core to caring for someone with long-covid is (1) believe them, (2) take a great history, likely focused on chest pain, fatigue, brain fog, mood disorder, difficulty...
  18. Mij

    Acute and chronic CNS oxidative stress/toxicity during hyperbaric oxygen treatment of subacute and chronic neurological conditions, 2024, Paul G Harch

    Introduction: Oxygen toxicity has been defined as acute central nervous system (CNS), acute pulmonary, and chronic pulmonary oxygen toxicity. This study identifies acute and chronic CNS oxygen toxicity under 2.0 atmospheres absolute (ATA) pressure of oxygen. Methods: The authors’ medical records...
  19. Mij

    Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19, 2024, Hanson et al

    I tried a gluten free diet for almost a year even though I tested negative for gluten sensitivities, I cooked with cast iron pots, ate plenty of liver and roasts with vitamin C, took digestive enzymes that might have helped a little, eradicated h pylori, ate fermented foods . . . I...
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