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Seems to suggest severity of neurological Long COVID symptoms is not associated with severity of acute infection. See study thread

Relevant to the fact mild infection is seen as much in long COVID as severe

Background A variety of symptoms, particularly cognitive, psychiatric and neurological symptoms, may persist for a long time among individuals recovering from COVID-19. However, the underlying mechanism of these brain abnormalities remains unclear. This study aimed to investigate the long-term...

Also @Dakota15 would it be possible to put tweets in quote boxes when you share them. Them loading slowly when they are not in quote boxes sometimes makes my browser crash. (I’m on a very old device).

It’s actually pretty sad how little is being spent on basic biomedical research, and as a result, how little we know about the actual disease process.

Given these results though. It sounds like the main effect was that: “people with Long COVID (without PEM) who exercise tend to improve exertional capacity” And not “people with Long COVID (without PEM) have an improvement in their illness due to exercise”. Because the main improvement not...

And it’s a randomised controlled trial? And objective primary outcome measures? That’s probably the best methodology I’ve seen on a Rehabilitation study yet.

It seems cytotoxicity (the ability of a stressor to damage cells) can be a phenomenon that is delayed in comparison to the original stimulus. Ie. it seems depending on the immune or chemical leading to cytotoxicity it can occur instantaneously to a week after. [1] It seems also a well regarded...

Also do note that the author of this paper isn’t very ME informed. ie. https://www.cell.com/trends/neurosciences/abstract/S0166-2236(13)00196-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0166223613001963%3Fshowall%3Dtrue

If we knew, we probably wouldn’t be here. In my opinion given the lack of findings, it’s probably related to a complex mix of factors which are very hard to understand from a human POV, and machine learning with large data samples is likelier to make sense of it.

Abstract: Current research into mood disorders indicates that circulating immune mediators participating in the pathophysiology of chronic somatic disorders have potent influences on brain function. This paradigm has brought to the fore the use of anti-inflammatory therapies as adjunctive to...

Aswell as this potentially being relevant to ME/CFS, because one theory is that the body is stuck in a persistent “sickness response” loop following physical trauma, this is particularly interesting given the metabolic problems found in ME “Interestingly, many alterations associated with...

Abstract: Everyone knows that an infection can make you feel sick. Although we perceive infection-induced changes in metabolism as a pathology, they are a part of a carefully regulated process that depends on tissue-specific interactions between the immune system and organs involved in the...

So do I. I feel a possible hypothesis is that there is a negative feedback loop somewhere in the sickness response of pwME which leads the body to dysregulate itself in all sorts of ways possibly never managing to completely leave the “sickness response” state. Many of which might contribute as...

Abstract: Sufficient evidence is now available to accept the concept that the brain recognizes cytokines as molecular signals of sickness. Clarifying the way the brain processes information generated by the innate immune system is accompanied by a progressive elucidation of the cellular and...

“These effects [physiological response to acute infection] result in decreased muscle and aerobic performance, the full recovery of which may require several weeks to months following week-long febrile infections.”

Abstract: Acute infections are associated with multiple host responses that are triggered by cytokines and correlated to fever, malaise and anorexia. The purpose of this systemic acute phase host reaction („the acute phase response”) is to mobilize nutrients for the increased needs of the...

Abstract: Exertional fatigue, defined as the overwhelming and debilitating sense of sustained exhaustion that impacts the ability to perform activities of daily living, is highly prevalent in chronic kidney disease (CKD) and end-stage renal disease (ESRD). Subjective reports of exertional...

You just taught me something new today, thanks! I imagined if it didn’t work with the “edit” function it wouldn’t work at all.