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So it looks as if when hyper mobility and ME/CFS occur together they don't have much to do with each other. All Rowe now has to do is a proper population study to check his continued assumption that hypermobility is a 'risk factor' for ME/CFS. I bet it isn't. A Beighton score of 4 in a young...

In clinical pharmacology it takes tens of thousands of scientists decades to develop treatments, 95%+ of which fall at one hurdle or another, to get a few effective treatments. In clinical psychology all you need to do is ask the patient some gossipy questions about themselves and dream up a...

I am afraid so. I am fairly sure that this is a group of physios who have had the brilliant idea that what patients need is more physio: lots of nice exercises taught by terribly nice physios who really care for the patients. They know nothing about the causes of joint pain and have no idea why...

I am primarily talking about UK. ICUs are full at present so things are being run at the absolute limit of what might be justifiable (if you even think one person in ICU is justifiable). My point is that despite pretty much letting loose the numbers are high but not rising. That means that...

I think it is reasonable. The only real reason why anyone is interested in enteroviruses in ME is that way back in the time the Royal Free outbreak neurological features raised the suggestion of a novel enterovirus. But it was never found and the neurological features are not recognised today as...

A jab of Kenalog would probably make most people feel zipped up and free of lots of symptoms like sore lymph nodes and joint pains. The downside is that steroids over a period of time have lots of adverse effects. In the 1980s and 1990s rheumatologists used shots of steroid a lot because the...

I cannot work out what Prusty's slide is supposed to indicate.It doesn't seem to have anything to do with high C1q levels. C1q contributes to formation of C1 complex, not the other way round.

The key question would be why a difference inC1q has not been picked up before. It is not measured routinely in the UK but probably would be in the US. I have not looked through the whole paper but I don't know if it gives a trawl of previous studies of C1q. Sorensen and colleagues did detailed...

It should have protocol and ethical approval.

No it is nonsense - at least in the sense that it is as implausible as saying that when you look at a red rose a bit of your brain turns red. There is an old saying. Keep an open mind but not so open that your brain falls out!

The stuff about microwaves and brains looks like straightforward nutcase pseudoscience to me. If it had any basis it would have been well documented decades ago. The idea of microwaves interacting with brain tissue to make' sounds' is plain nonsense.

Interesting that you found that. Going through the thread I was just about to remark that MBL is generally thought of as protector against extracellular toxin producing bacteria like staph aureus and if anything might be a bad thing when it comes to intracellular pathogens. If pathogens have...

The first author works in an immunology department where people with things like MBL deficiency probably turn up more often. Ditto subclass deficiencies.

That seems unlikely. We are just beginning to get to a state of herd immunity with 80% of adults vaccinated. The fact that the numbers of cases are flat despite hardly any restriction suggests that it is working, even with delta.

What is the reference to a treatment that works about?

I think if headline case numbers fall to 1,000 per day risk will be pretty small. There are lots of hidden factors that make the headline figures on their own misleading. I think risk now is much small even with figures still high. Certain sections of the community tend to mediate spread at any...

Covid-19 will fade into the background and become a minimal risk. We are not beyond the point of being able to eradicate Covid19. We haven't got near that yet. Having not done what New Zealand did it was bound to take 2-4 years to get enough people immune for the virus to stop spreading. Our...

I thought the phoenix was a fairy story.

It's in what counts, he said innocently.

We recommend that physiotherapy treatment is based on a biopsychosocial aetiological framework. This is just bad medicine. In modern medicine we do not base treatment on theoretical frameworks. We base it on evidence of safety and efficacy. It is salutary to compare this statement with what is...