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It is great that this is being done. We need solid evidence if these drugs work, not just for treatment, but also as clues as to what is going wrong in the body. We know they aren't cures, but there's still a lot of value in definitely establishing what they do or don't do. I think this kind of...

They really don't give you much with only a median and Mann-Whitney values, but it does look like something. I guess what's needed now is to repeat this in another chronic illness control group, to see if this is meaningfully about LC or just a general marker of illness.

In the absence of any kind of data coming from these doctors and surgeons (which is a big read flag by itself), I think it would be great if someone approached this question as an investigative journalist and tried to actually pull together something on how many people are actually improving...

Supplementary material here.

Abstract SARS-CoV-2 mRNA vaccination can entail chronic fatigue/dysautonomia tentatively termed post-acute COVID-19 vaccination syndrome (PACVS). We explored receptor autoantibodies and interleukin-6 (IL-6) as somatic correlates of PACVS. Blood markers determined before and six months after...

Being a victim of sexual assault is also associated with heart disease, hypertension, diabetes and all kinds of negative health outcomes that definitely aren't functional.

36% mean symptom improvement for the treatment arm versus 25% for the placebo isn't nothing, but it's not huge.

ME/FM Society of BC is active.

Agreed, though I think it's a little more complex than that, it's a limitation on total power output over a certain threshold for a certain time. So maybe I can lift an object without causing PEM (a significant power output), but I can't lift the same object five times in a row (the same power...

They don't seem to have any controls in this study or any pre-Covid data, so it's all based on normals for healthy people, which it's not clear these patients were (in fact, some of them were smokers, etc).

Naive perspective here, but the oxygen has to go somewhere, doesn't it? So if the theory is normal arterial oxygen and low venous oxygen, then you would pretty much have to find higher venous carbon dioxide and higher exhaled carbon dioxide than you would expect for a given effort, which I feel...

To be flip, I think ME is caused by infection, most commonly, but not exclusively, viral (and maybe other immunological events). Beyond that, who knows? It probably has something to do with the immune system.

There is very little research in this area and I don't think we have any real answers as to what post-viral fatigue is or if post-viral fatigue differs from ME/CFS. I suspect they are the same thing or closely related, since the symptoms are often very similar and there doesn't seem to be a...

I don't think anyone has found solid evidence of viral persistence in chikungunya, west nile (or dengue for that matter, they are all related). Borrelia is a bacteria.

Isn't it also the case that some people with LC report it resolving after another Covid infection, which is what the three people in this study had? Why is it assumed to be related to the mAbs instead of the infection itself?

Karikó was in Robert Suhadolnik's lab at Temple from '85-'88 and Suhadolnik was involved in CFS research for quite a while. Here's a paper from him on a trial of Ampligen in CFS, though it seems to be a few years later (don't have access to the actual paper).

I also have noted that I fill blood test tubes more slowly since I've been sick. Blood looks thick to me, but I don't have a lot to compare it to. Maybe I'll ask next time I'm in for a test.

No, we're going to lie down!

Wouldn't we also expect that if you take any general cohort of people who have been diagnosed with ME or CFS, you're going to get a lot of people who probably do have something else? Maybe ME is more than one thing or maybe you have a bunch of people misdiagnosed, but I'd be immediately...

Some people do spontaneously recover (I believe more than we think, because many of them haven't been sick enough long enough to know they have ME), which makes it seem unlikely that there is serious permanent damage. And people get significantly better or worse over time. You'd think if ME was...