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This was the only agenda I was hearing at the Round Table.

About 20 people, now up to 37, testified in a closed Facebook group to exactly the same kind of symptoms: numbness, tingling, a feeling of fire in the body, tinnitus, all linked to the time of vaccination, often immediately after injection. For a population of ten million you would expect at...

It all sounds very nice but reminds me of the Round Table member who introduced themselves as the 'friendly sort of psychiatrist (with artificial smile) presumably to distinguish them from people who do trials of GET and CBT, although those surely should not be dismissed out of hand... If GPs...

Not by me. I thought it would be more useful to write to the authors personally.

Basically it says 'We don't understand how to assess evidence'. Evidence from gold-standard randomised controlled trials (RCTs) finds that graded exercise therapy (GET) is an efficacious treatment for chronic fatigue syndrome (CFS) [1,2]. We compared self-report clinical outcomes from...

It is what the predictive coding people call predictive coding. I spend most of my time when not thinking about ME thinking about perception and writing articles on it. The predictive coding people are the main neurobiological theorists involved. They consider the brain to be a prediction...

That is a reasonable point but predictive coding applies much more widely than proprioception. It is relevant to colour and shade vision and to sounds, including speech perception. If the brain predicts that a square on a picture of a chessboard is in the shade of a vase then it will interpret...

I had never heard of assays of this type. They seem to be looking at thrombus formation ex vivo in plate-poor plasma. I have no idea what relevance that has to putative presence of clots in vivo.

All this stuff about thrombosis seems to me to be hot air from people who don't understand immunology. I am fairly sure it is all an artefact.

We revisited this fairly recently in the thread If and How to Research Pacing, I think. The original discussion is probably four or five years ago when we were discussing what projects were worthwhile around the time of DecodeME being assessed.

The predictive coding theory of Hohwy, Friston and others says that what we experience is what the brain calculates to be the difference between what it expects to sense and what comes in from sense organs. So if the brain thinks it is going to sense being by the third platform bench and what...

Yes they are. Mark Edwards published it about three years ago I think. It is all based on Karl Friston and Jacob Hohwy stuff but as far as I could see Edwards's 'model' would predict the opposite of what he said. It is all very hand-waving because nobody actually has any evidence for this...

https://www.theguardian.com/society/2022/apr/16/nhs-smartwatch-for-parkinsons-patients-hailed-as-lifechanging Piece in the Guardian about using actometers in Parkinsons. I am a bit sceptical that they will be so useful in routine practice. The main sell is that they avoid actually going to...

And men doctors - like no need to check for prostate cancer Jo.

This is plain make-believe. My colleagues should be ashamed of producing this sort of thing. They may have developed a model based on predictive coding, but until that model is coherent and testable saying that the patients' brains have a model is just fabrication. Edit: As the man said; Deepak...

I think this is interesting in that it gives the lie to the claim that it is only a small vocal minority of patients who are dissatisfied with the BPS approach. So many patients object to this approach that the treatment programme has to be redesigned. I am also interested in the candid...

But they probably aren't. The abstracts suggests that they are looking at whether the existence of the psychological factors will predict that the person already has FM. The usage of predictor in studies like this is often not temporal, merely associative. And of course anyone with a diagnosis...

Those are informal lay information pages. Nothing to do with medical definitions. No clinician is going to think MS is defined like that. It is defined in terms of CNS demyelinating episodes multiple in space and time and has been for decades.

I not yet been able to access anything that says they have concrete results with this. What I can see is that they have done an open phase 1 study. There may be more data I cannot access. We know that MS responds well to B cell depletion - using rituximab or newer agents. ME doesn't respond. If...

I was only involved in the S4ME response to enquiry on the draft. I agree that it looks as if the NICE GRIP committee is taking this forward with some people from ForwardME. Nina and I seem to be in quite good agreement as to what might be advised in terms of service planning but like you I...