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Trial By Error: A Few Interesting Studies By David Tuller, DrPH

Fritscher-Ravens A, Pflaum T, Mösinger M, et al. Many Patients With Irritable Bowel Syndrome Have Atypical Food Allergies Not Associated With Immunoglobulin E. Gastroenterology. 2019;157(1):109-118.e5. doi:10.1053/j.gastro.2019.03.046...

Doesn't sound good. There a couple of forum threads about research papers co-authored by prosjektleder Egil Andreas Fors, e.g. the one on neuropsychological dysfunction in CFS/ME here. List of Publications: https://www.ntnu.edu/employees/egil.a.fors

"Clinical Champion? What’s that?" https://www.rcgp.org.uk/clinical-and-research/about/clinical-news/2019/february/clinical-champion.aspx

Way too much text, too many articles and comments for me to catch up with. PEM today from just trying it. Having PEM from things that seem very good news is a comfortable situation though compared to engaging with all the bad science and with the vilifying that has been coming from 'CFS'...

Interesting that the Times' print edition titled without the 'F'-word: "Search for genetic clues to ME" -- whereas in the online edition it's "Chronic fatigue syndrome: Search for genetic clues"

Congrats and huge thanks to all involved!

David Tuller: Trio of Trials Shows Limits of CBT for Medically Unexplained Symptoms https://www.virology.ws/2020/06/17/trial-by-error-trio-of-trials-shows-limits-of-cbt-for-medically-unexplained-symptoms/

Yet I think it could be extremely helpful to have all of David Tuller's ( @dave30th ) criticism, also regarding MUS, on pubpeer, too. Could be also better searchable than Virology blog and S4ME. https://pubpeer.com/static/about Since there are sometimes people asking for easy volunteer work...

(Continued from my previous post.) So what I basically wanted to say or ask is: 1. It's good that you're here. I see that the language we use regarding blinding and subjective and (potential) objective outcomes/ endpoints etc. could be more precise to avoid misunderstandings. From the forum...

Hi Hilda, I don't know whether I will be able to reply to some of your and others valuable posts within reasonable time, but I'd like to let some non-substantial thoughts here. I wrote this over the last days, so apologies if some points are now redundant. To facilitate reading, I will post...

There is also the worrying role the Sciene Media Centre (UK) played in presenting the Lightning Process trial (SMILE): https://www.virology.ws/2017/12/18/trial-by-error-my-questions-for-the-science-media-centre/ What I don't recall now is whether the trial investigators reported how school...

Participants of this study were recruited as part of an ongoing RCT: Twomey R, Martin T, Temesi J, Culos-Reed SN, Millet GY. Tailored exercise interventions to reduce fatigue in cancer survivors: study protocol of a randomized controlled trial. BMC Cancer. 2018 Jul 24;18(1):757. doi...

Just realized that we don't have a subforum on trial methdology, so I hope it's OK to leave this here: Looking around what diverse experts say on the need for objective outcomes in open-label trials I repeatedly came across the Centre for Evidence Based Medicne (CEBM) at the University of...

Another example: https://twitter.com/SnowyPanthera/status/1222476712203575297 I realize that this is a difficult field especially with regard to objective measures in mental illness, and I admit I can't remember how the argument that certain trials were not 'unblinded' but 'assessor-blinded'...

I missed that. What do you mean by a valid example, @Medfeb ? Do you mean that investigating pain as an outcome in an unblinded, not adequately controlled trial with self-reported pain relief as the only measure is valid? I found these statements by @Hilda Bastian: I am not sure what you...

I'm still only able to occasionally read and post, so again apologies for missing most of the discussion when replying to a particular post. Yes, having objective outcomes that are only self-reported is also problematic. I think there mostly exist some ways to reduce the risk that objective...

Did anybody actually say this? I think it's clear for all of us that including relevant subjective endpoints is always highly valuable, also in unblinded trials, but the point some of us repeatedly are trying to make is that if you, in unblinded trials, don't at the same time, in addition to...

Still not able to catch up with this and related threads, so again apologies for just jumping in. Perhaps an open letter signed (only) by psychologists and psychiatrists could help debunk the argument that all criticism that a certain branch of psychologically informed research on ME receives...

Hi @Hilda Bastian, thank you for your replies and for joing the forum as a guest. Haven't caught up with this thread yet, so apologies for just popping in. I still don't understand why all the well-founded criticism of the exercise review is not reasons enough to retract it, at least...