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Yes, the immunohistochemistry confirms a diffuse cytosolic distribution without any obvious membrane staining - a long way away from any haemoglobin I am afraid.

I don't think it is anyone's 'belief'. I think it is something that has been demonstrated empirically many times. And if the moving macromoleules in the membrane are not congruent down to below 5 Angstrom units and have plenty of non-polar areas what is to stop the oxygen going through? There...

Yes but you were talking about autoimmunity - a quite different mechanism from allergy. Are there such tunnels? I have not heard of any, certainly not associated with myoglobin. If the immune system 'destroys' structures there will be inflammation, visible on MRI and histology. If an...

I don't know of anywhere it is defined as that. It is normally defined as a worsening of symptoms that includes fatigue, pain, and also things like nausea, orthostatic intolerance, sensitivity to light and so on (i.e. the patient symptoms we don't want to dismiss). We don't know whether it has...

Is myoglobin actually on the outside of the muscle cell? I had thought it was inside. There is no need to take oxygen off haemoglobin. At cellular scale molecules like oxygen and water are zipping about all over the place and through membranes at unimaginable speeds.

Hi, @FStevenChalmers, I think you are right, this is wrong, but discussion of these things often reveals unexpected ignorances in all of us and we learn a bit. I am unclear why you want to invoke a hapten. Autoimmunity has nothing to do with haptens or trigger antigens as far as we know, other...

As far as I can work out the 'Government Delivery Plan' says nothing about provision of services. My limited involvement in service development suggests to me that it is delegated to people in local Trusts who probably have no real understanding of any of this. Patients may get involved but...

But I think MrMagoo is essentially right. Physios for ME are people who happen to be Physios who understand the problems with physio approaches to ME/CFS. And those problems relate to a general problem with a profession that it is based on a practice of doing what you think ought to work...

The approach to the patient is now so holistic that it includes olfactory training: 'Try smelling this marmalade - that is what we call marmalade smell.' 'Now let's move on to bananas'...

'We have no evidence but we are doing a jolly good job anyway'. Seems to be the message.

Yes, the hypothesised bad prediction should give the opposite result on a comparison and update model. In fact the whole predictive coding thing is pretty rubbish because it muddles up all sorts of different neural computational processes. The main predictive coding aspect is oculomotor. Our...

I think that analysis is a misunderstanding. Predictive coding has nothing to do with explaining how we do things 'too fast'. That is an argument about the role of conscious percepts, which occur too late to explain what the brain does in action. The nerve pathways are fast enough. It is just...

This seems to be just a retrospective study with no controls. And a tiny group so serious adverse reactions might not be picked up (they occur very long term). There was a death from opportunist pneumonia it seems even so. I don't see the point in this. My experience from talking to people...

Hi, @AR561, Yes, I have got familiar with the 'chiropractic medicine' side of things since being interested in ME/CFS and have come across Keiser and MSK Neurology. This is all just fake medicine in my view. The methods they sell have no scientific basis and no evidence basis in clinical...

You have lost a K in the title @ME/CFS Skeptic!

Of course a study of this sort will never identify the 679 procedures that weren't done in other people and might have been of use. This sort of moralising overgeneralising approach to medicine has always been around and should be ignored. All a doctor can do is make the best decision they can...

Seems like a rag-bag of tests on a small number of people with presumably no information on what those tests showed before Covid or whether their occurrence was due to Covid or coincidence. Since we do not have any clear evidence of relation of Covid to any specific neurological abnormality...

Hi @AR561. I am a professor of medicine trained in neuroscience and clinical neurology but not a neurologist. I accept that, like all neurological signs, these signs are useful in coming to a diagnosis. No single sign is 'rigorous' in neurology. The diagnosis always depends on the entire...

I would be very pleased to add my name to your letter @Trish.

I have been getting suspicious about the poor quality of BPS papers posted on the forum. I can no longer believe that these can be the best BPS papers on ME/CFS or Long Covid or anything else. Illustrious posters like Andy and SNT Gatchaman who have been bombarding us with very bad papers must...