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Well, if the animals made antibodies to the bacteria in the transplant, why would you need antibodies from patients as well? It doesn't make any sense at all to me. Maybe the idea is that the patients' antibodies bind to the bacteria in the gut. But if the bacteria are in the gut then binding...

Hard to know from the above but I don't understand why the mice are having feral transplants as well as patient IgG.

The Beighton score was never shown to be a useful marker of anything. It was just made up. But if hypermobility is nothing to do with anything much, except for those with shoulder dislocations or knock knees then the whole thing is a waste of time anyway.

But lots of people are bendy anyway. Anything from 20-40 of young women can score as 'hyper mobile'. So yes lots - regardless of having ME/CFS. There seems to be no more evidence that it is a 'distinct phenotype' than having ME/CFS and brown eyes to be honest.

Cannot see how you are going to recruit people with significant PEM from an advertisement for people with fatigue. When I had Long Covid mildly there is no way I would have volunteered for a study like this. Anyone I can think of with significant ME/CFS I would expect to keep well clear of this...

It is pretty hard to understand what anyone would take it seriously, unless of course it provides an income for them.

Apart from anything, amongst this long list of things the patient is supposed to fill in there is no evidence whatever of any CARE AND SUPPORT PLAN. It is just a dummy placebo form.

I think a letter would be good idea. Maybe something should come from S4ME officially. I get the impression that both MEA and AfME are falling for this multidisciplinary care plan garbage.

Physically doing my treatment(s) (sometimes/always) Funny how that gives the game away. The entire thing is an exercise in multidisciplinary team (holistic) marketing to ensure that the team goes on having a job by ticking the right 'done that' boxes. As a doctor I never had any use for...

Good Blog and thread @ME/CFS Skeptic. I am a bit out of contact at present but this all makes a lot of sense.

I think that has more to do with the emetic effects of things like opiates, often used as part of anaesthesia. But maybe similar in that the problem is not in the gut nerves themselves.

I can believe that compression syndromes of one sort or another occur rarely as developmental problems in young children. But everything tells me that the use of this explanation in young adults with GI symptoms is likely to be 95% bogus. I say that as much as anything because I saw so much of...

I am glad to hear it but concerned it is only 255 for juniors. Since when did we know enough to prescribe neuromodulators for 'DGBI'. This is the FND story all over again it seems.

So maybe this is Munchausen by gastroenterologist?

But that still gives us no proof even in that case that the compression was actually relevant. It was there but how do we know it caused the clinical problem? People get better after surgery for all sorts of reasons, as we know. You may be right but I have yet to see a single image relating to...

We seem to be hearing more and more of this stuff. The British Society for Gastroenterology group that are anti feeding support for 'functional' cases are weighing in with reference to hEDS. They don't mention vascular compression but I suspect it is all part of the same fashionable meme-talk...

This is an interesting case but it raises as many questions as answers, as SNTG says. If gastroparesis is due to failure of stomach nerves then how come it improved? Autonomic nerve damage does occur in diabetes but that is a very different context. The NHS information page says: Gastroparesis...

That is a clinical review by physicians with an interest in selling gastroparesis so I would treat it with caution. Sadly, medicine is now awash with these promotional reviews by people who don't necessarily have the scientific skills they seem to. Uncontrolled diabetes is known to lead to...

I would be sceptical that this will lead to any enlightenment. People study EEG because you can measure things. They love complicated mathematical procedures like power spectra. But nobody has any idea how brain rhythms relate to thought. They are almost certainly just gross co-ordinating and...

I mean that it looks as if we may not just be dealing with callousness from professional groups but deliberately targeted callousness out of self interest. Gasroenterologists make a good living out of procedures like endoscopy, and I suspect make use of clever diagnoses like EDS-related gut...