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  1. Sean

    Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to Two Years Following COVID-19, 2023, Peluso +

    I did not mean every one of them, I should have made that clear. But I think it quite plausible that at least some people who otherwise appear healthy can have subtle long-term reductions in performance without noticing it.
  2. Sean

    Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to Two Years Following COVID-19, 2023, Peluso +

    One possibility here is that these apparently healthy people do have some, probably quite minor, adverse effects from the viral persistence, but that the way reduced health status is currently defined and screened for is not picking up these effects, including misattribution to other factors...
  3. Sean

    Trial Report Daily Multidimensional Fatigue Scale and Physiological Indicators to minimize Subjective Bias in assessing Fatigue Levels, 2024, Lee

    No idea how good this study is. Too brain dead at the moment to look closely. But at least somebody is trying to pin this down.
  4. Sean

    UK: All Party Parliamentary Group (APPG) on ME news, 2020 onward

    1. those who were harmed by or been through the GET and CBT generation and have had it eg decades need something different currently to newer diagnosed. I think this is important.
  5. Sean

    Reflections on the CODES trial for adults with dissociative seizures: what we found and considerations for future studies 2024 Stone, Carson, Chalder+

    “DS are maintained by a vicious circle of behavioural, cognitive, affective, physiological and social factors of which fear and avoidance are particularly salient.” Yet they cannot offer any evidence for that utter certainty. This is so far outside of widely recognised empirico-logical...
  6. Sean

    News from Scandinavia

    However, pacing is not as easy to achieve as we might think. I think this is an important point that needs to be more prominent. Though it does also open the doors to hacks and opportunists everywhere to play the expert at 'teaching' patients how to do it.
  7. Sean

    The effect of expectancy versus actual gluten intake on gastrointestinal and extra-intestinal symptoms in non-coeliac gluten..., 2024, De Graaf et al.

    Every relevant significant factor. Not everything needs to be controlled. Figuring out which ones to control, and how, is the key skill here. Yes, and yes.
  8. Sean

    Illness presentation and quality of life in [ME/CFS and LC]: a pilot Australian cross-sectional study, 2024, Weigel, Eaton-Fitch, Marshall-Gradisnik+

    Importantly, post-exertional malaise—the defining feature of ME/CFS—was equally as common, severe and frequent among pwPCC. If this finding in particular holds up in then it is important. Just confirms the view held by many from early on, including me, that even if they are not exactly the...
  9. Sean

    TeamClots vs Cochrane

    randomised controlled trials It is the controlled bit that is the core. Randomisation is just one form of control, albeit an important one. On its own it is insufficient, however much the psychosomatic club may wish it to be sufficient.
  10. Sean

    How to best move the understanding of ME/CFS forward (and the forum's role in that)

    Yeah, that was never part of the mission statement. And took 8 years to do it. :grumpy:
  11. Sean

    Review Functional neurological disorder, physical activity and exercise: What we know and what we can learn from comorbid disorders 2024 Boylan et al

    In this traditional narrative literature review, Off to a bad start. (I am not a fan of narrative reviews at the best of times, traditional or otherwise. They are mostly just pseudo-scientific manifestos promoting the authors' ideological prejudices, in my humble opinion.) (Also, FBM is...
  12. Sean

    Acceptability and feasibility of a theatre-based wellness programme to support people living with long COVID, 2024, Burton et al.

    Should have had a control group that just gave the patients the money that would have been handed to the arts practitioners.
  13. Sean

    Reflections on the CODES trial for adults with dissociative seizures: what we found and considerations for future studies 2024 Stone, Carson, Chalder+

    That is a straight up admission that the trial failed, and the FND club are hardcore anti-science psycho-ideologues. This.
  14. Sean

    Family healthcare patterns as a proxy for transgenerational transmission of functional somatic symptoms in early childhood... 2024 Hogendoorn et al

    Poverty is the greatest cause of poor health and premature death. Excusing society from dealing with it, and instead blaming the victims, is just sickening cruelty.
  15. Sean

    Family healthcare patterns as a proxy for transgenerational transmission of functional somatic symptoms in early childhood... 2024 Hogendoorn et al

    Conclusion Family healthcare use, especially within the general practice, may play a role in the transgenerational transmission of FSS. Early-stage FSS identification and care might be improved through training aimed at GPs. Future research may identify vulnerable families at whom parent-focused...
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